Mark W. Woods

Recognition of cancer in vivo by nuclear magnetic resonance.

Pulsed nuclear magnetic resonance has been used to differentiate in vivo between normal mouse tail tissue and a malignant transplanted melanoma, S91, located on the tail. The tumor displayed a nuclear (proton) spin-lattice relaxation time of ∼0.7 second contrasted with the simultaneously measured normal tail tissue relaxation time of ∼0.3 second.

Effect of Bacterial Endotoxin in Germ-free Mice

Summary Germ-free and conventionally reared mice of similar genetic stock maintained on the same sterilized diet were compared as to their reaction to bacterial endotoxin. No significant difference was found in the following: elevation in levels of antibody to Gram-negative bacteria, stimulation of glycolytic activity of spleen cells and peritoneal macrophages, susceptibility to infection with Salmonella typhosa, production by endotoxin of increased resistance to infection, and LD50 of endotoxin.

INHIBITION OF TUMOR CELL GLYCOLYSIS BY DPNH2, AND REVERSAL OF THE INHIBITION BY DPN, PYRUVATE OR METHYLENE BLUE.

The discovery of the active group of the hydrogen-transferring enzymes — nicotinamide — for which OTTO WARBURG was nominated by the Nobel Committee 1 “for a prize for the second time in 1944, when he again was found to deserve the honor”, has had a profound influence on all of biochemistry. The present paper describes a fundamental inhibition of intracellular tumor metabolism produced by reduced diphosphopyridine nucleotide (DPNH2) added extracellularly.