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Markus Follmann

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Publication

Featured researches published by Markus Follmann.

Journal of Medicinal Chemistry | 2015

Novel Small Molecule Inhibitors of Activated Thrombin Activatable Fibrinolysis Inhibitor (TAFIa) from Natural Product Anabaenopeptin

Nis Halland; Mark Brönstrup; Jörg Czech; Werngard Czechtizky; Andreas Evers; Markus Follmann; Markus Kohlmann; Matthias Schiell; Michael Kurz; Herman Schreuder; Christopher Kallus

Anabaenopeptins isolated from cyanobacteria were identified as inhibitors of carboxypeptidase TAFIa. Cocrystal structures of these macrocyclic natural product inhibitors in a modified porcine carboxypeptidase B revealed their binding mode and provided the basis for the rational design of small molecule inhibitors with a previously unknown central urea motif. Optimization based on these design concepts allowed for a rapid evaluation of the SAR and delivered potent small molecule inhibitors of TAFIa with a promising overall profile.

Archive | 2009

Substituted aminoindanes and analogs thereof, and the pharmaceutical use thereof

Nils Rackelmann; Laurent Bialy; Heinrich Christian Englert; Klaus Wirth; Petra Arndt; John Weston; Uwe Heinelt; Markus Follmann

Archive | 2009

Chlorothiophene-amides as inhibitors of coagulation factors xa and thrombin

Markus Follmann; Volkmar Wehner; Jerome Meneyrol; Jean-Michel Altenburger; Frédéric Petit; Gilbert Lassalle; Jean-Pascal Herault

Archive | 2007

Urea and sulfamide derivatives as tafia inhibitors

Christopher Kallus; Mark Broenstrup; Werngard Czechtizky; Andreas Evers; Markus Follmann; Nis Halland; Herman Schreuder

Archive | 2009

TARTRATE DERIVATIVES FOR USE AS COAGULATION FACTOR IXa INHIBITORS

Henning Steinhagen; Markus Follmann; Jochen Goerlitzer; Herman Schreuder

Archive | 2007

ISOSERINE DERIVATIVES FOR USE AS COAGULATION FACTOR IXA INHIBITORS

Henning Steinhagen; Markus Follmann; Jochen Goerlitzer; Herman Schreuder

Journal of Medicinal Chemistry | 2016

Sulfamide as Zinc Binding Motif in Small Molecule Inhibitors of Activated Thrombin Activatable Fibrinolysis Inhibitor (TAFIa)

Nis Halland; Jörg Czech; Werngard Czechtizky; Andreas Evers; Markus Follmann; Markus Kohlmann; Herman Schreuder; Christopher Kallus

Archive | 2011

Derivatives of aminoindanes, their preparation and their application in therapeutics

Markus Follmann; Pascale Goberville; Stéphanie Hachtel; Gerhard Hessler; Heinz-Werner Kleemann; Thomas Maier; Cort Gary Mc; Carsten Strübing; Berangere Thiers; Li‐hsing Wang

Archive | 2009

UREA AND SULFAMIDE DERIVATIVES AS INHIBITORS OF TAFIa

Christopher Kallus; Mark Broenstrup; Werngard Czechtizky; Andreas Evers; Markus Follmann; Nis Halland; Herman Schreuder

Archive | 2008

MALONAMIDE DERIVATIVES WITH ANTITHROMBOTIC ACTIVITY

Henning Steinhagen; Hauke Szillat; Markus Follmann; Reinhard Kirsch; Volkmar Wehner; Hans Matter; Martin Lorenz; Kent W. Neuenschwander; Anthony C. Scotese

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Collaboration

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Herman Schreuder

Aventis Pharma

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Andreas Evers

University of Marburg

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Heinrich Christian Englert

Aventis Pharma

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Klaus Wirth

Aventis Pharma

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Volkmar Wehner

University of Stuttgart

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Uwe Heinelt

Case Western Reserve University

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Jörg Czech

Aventis Pharma

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Henning Steinhagen

Bayer

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Anthony C. Scotese

Aventis Pharma

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Hauke Szillat

Aventis Pharma

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