Markus Grunewald
University of Erlangen-Nuremberg
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Featured researches published by Markus Grunewald.
Open Medicine | 2007
Wolfgang Wuest; Torsten Kuwert; Markus Grunewald; W. Bautz; Raimund Forst; Andreas Mauerer; Rainer Linke
Bone scintigraphy, although quite sensitive to detect skeletal lesions, has a comparatively low specificity. Hybrid-cameras combining single-photon emission computed tomography (SPECT) and spiral-CT offer the opportunity to correlate scintigraphic information with high-quality visualization of morphology in one session. This may lead to an improvement in diagnostic accuracy and anatomic lesion localization. We present 11 patients, who underwent SPECT/CT of the feet (n=10) and hands (n = 1). The examinations were performed due to pain in foot or hand with the following suspected clinical diagnoses: arthrosis (n=1); fracture (n=3); osteomyelitis (n=4); reflex dystrophia (n=1); and, pain of unclear origin (n=2). All patients underwent SPECT/CT hybrid imaging using a dual-headed SPECT camera integrated with a 2-slice spiral CT scanner in one gantry. SPECT, CT, and SPECT/CT were evaluated independently from each other with respect to main diagnosis, anatomic lesion localization, and detection of a possible additional diagnosis. SPECT/CT improved lesion localization in 8 of 11 patients (73%) in comparison to SPECT alone, and in 4 of 11 patients (36%) in comparison to CT alone. Diagnostic accuracy was improved in 4 of 11 patients (36%) in comparison to either SPECT or CT alone. In conclusion, skeletal SPECT/CT improves diagnostic accuracy and lesion localization of orthopedic disorders in the feet and hands. The obtained results encouraged extensive studies to further investigate the potential gain in diagnostic accuracy brought about by SPECT/spiral-CT hybrid imaging in orthopedic disorders of the peripheral extremities.
Pediatric Radiology | 2004
Markus Grunewald; Roland Talanow; Matthias Wagner; Markus Spörl; H. Greess; W. Bautz; Markus Uhl
Received: 16 April 2004 Revised: 29 July 2004 Accepted: 29 July 2004 Published online: 26 October 2004 Springer-Verlag 2004 Sir, In paediatric skeletal radiography, it is difficult for the beginner to decide what is a physiological agespecific variation of a child’s bone and what should be deemed pathological. In comparison to skeletal radiography in adulthood, fewer radiographs are made in children due to radiation exposure. It is substantially more difficult for the beginner in paediatric radiology and the radiologist on-call to be cognisant of the ‘physiological reference image’. Furthermore, the relevant textbook may be unavailable or there may simply be insufficient time to find the appropriate reference image. As a matter of general interest to especially younger paediatric radiologists, we have developed an online program PEDBONE (http://www.tnt-radiology.de/pedbone). PEDBONE is a free reference database for almost all standard images in plain film radiography from infancy to adulthood. The database serves the radiologist oncall and the inexperienced paediatric radiologist undertaking routine reporting. PEDBONE also facilitates the determination of bone age in childhood and adolescence. Over the course of 1 year, approximately 300 paediatric skeletal radiographic images have been collected and, after specialized medical peer review, sorted by anatomical site (head, cervical spine, thoracic spine, lumbar spine, upper arm/ shoulder, etc.), age (1–20 years) and sex, the data being entered into a database. The database can be queried through selection of all three criteria, or additionally offers the possibility of selecting each criterion separately. The latter offers itself for determination of bone age using the left hand. At http://www.tnt-radiology.de/pedbone the chosen selection mode offers the user at least one reference image according to each body region, age and sex that is entered. PEDBONE has received positive feedback by its first users, in particular younger colleagues in the field and less-experienced paediatric radiologists. PEDBONE will be developed further—with even better image material and even more concise age representations. Users are also encouraged to offer their input. For this, PEDBONE’s continually updated table, located at http:// www.docmw.de/pedbone/table.htm, offers the possibility for colleagues worldwide to add their own images to this project. Colleagues worldwide can also send images to us that are currently not in our database through electronic or postal mail, and thus be listed as primary authors of that image. Images already available in the database are listed on the webpage, http://www.docmw.de/ pedbone/table.htm Pediatr Radiol (2004) 34: 1029 DOI 10.1007/s00247-004-1310-9 LETTER TO THE EDITOR
Medizinische Klinik | 2004
Igor Alexander Harsch; Patrick Michaeli; Steffen Mühldorfer; Markus Grunewald; Ulrich Baum; E. G. Hahn; Peter C. Konturek
D Aufnahme einer 72-jährigen Patientin erfolgte bei schmerzlosen peranalen Abgängen von Teerstuhl, später auch vermischt mit frischem Blut. Bereits zum Aufnahmezeitpunkt lag der Hämoglobin-(Hb-) Wert bei 9,7 g/dl und fiel bis auf 7,6 g/dl, was die Substitution von zwei Erythrozytenkonzentraten erforderte. Im weiteren Verlauf des Aufnahmetages und auch während der weiteren Tage der Hospitalisation blieb der HbWert stabil. Eine bereits während der Blutungsepisode durchgeführte Ösophagogastroduodenoskopie ergab keinen pathologischen Befund, in der unmittelbar nach der stationären Aufnahme erfolgten Koloskopie fanden sich multiple Sigmadivertikel ohne Zeichen einer frischen oder stattgehabten Blutung. In der Vorgeschichte der Patientin ist eine chronisch-obstruktive Lungenerkrankung (COPD) zu erwähnen, die mit inhalativen Antiobstruktiva und aktuell 5 mg Prednisolon/die behandelt wurde. Unter dieser Therapie bestanden noch eine mäßige Obstruktion und Dyspnoe. In den Tagen vor der Hospitalisation hatte die Patientin aufgrund von Lumboischialgien mehrmals Brausetabletten eines Mischpräparats aus 400 mg Acetylsalicylsäure und 250 mg Vitamin C getrunken. Die Dünndarmdoppelkontrastuntersuchung zeigte mehrere bis zu 3,3 cm durchmessende Dünndarmdivertikel, insbesondere im Jejunum (Abbildungen 1 und 2). Bei einer später durchgeführten Jejunoskopie gelang das Vorspiegeln bis in die vierte Jejunalschlinge, dort imponierten Divertikel vor allem in der ersten und zweiten Jejunalschlinge ohne Blutungszeichen (Abbildungen 3 und 4). Letztere Untersuchung war allerdings mehrere Tage nach dem akuten Blutungsereignis erfolgt. Wir gingen daher nach dem Ausschluss anderer gastrointestinaler Blutungsquellen von einer stattgehabten Blutung aus einem Dünndarmdivertikel aus. Dünndarmdivertikel sind aufgrund ihrer Seltenheit ungewöhnliche Ursachen einer gastrointestinalen Blutung (1–2%) [1]. Typischerweise handelt es sich um Pulsionsdivertikel, die an den Gefäßdurchtrittsstellen des Mesenterialansatzes lokalisiert sind. Ihre Häufigkeit steigt mit dem Alter [2, 3]. Im Fall der Lokalisation der Blutungsstelle (z.B. durch Angiographie, Kapselendosko1 Medizinische Klinik I mit Poliklinik und 2 Institut für Diagnostische Radiologie der Friedrich-Alexander-Universität Erlangen-Nürnberg.
Academic Radiology | 2003
Markus Grunewald; Rolf A. Heckemann; Harry Gebhard; Michael Lell; W. Bautz
Academic Radiology | 2007
Sedat Alibek; Johannes Zenk; A. Bozzato; Michael Lell; Markus Grunewald; Katharina Anders; Christina Rabe; Heinrich Iro; W. Bautz; H. Greess
Academic Radiology | 2004
Markus Grunewald; Rolf A. Heckemann; Matthias Wagner; W. Bautz; H. Greess
Academic Radiology | 2005
Matthias Wagner; Rolf A. Heckemann; A. Nömayr; H. Greess; W. Bautz; Markus Grunewald
Academic Radiology | 2006
Markus Grunewald; Dominik Ketelsen; Rolf A. Heckemann; Johannes Zenk; Christoph Schick; Brigitte Bison; Dirk Anders; Inés Knickenberg; Matthias Wagner; Winfried Neuhuber; Andreas Bickel; W. Bautz; H. Greess
Hno | 2005
Markus Grunewald; Johannes Zenk; Sedat Alibek; Inés Knickenberg; Dominik Ketelsen; Heinrich Iro; W. Bautz; H. Greess
Society of Nuclear Medicine Annual Meeting Abstracts | 2007
Markus Grunewald; Anton Noemayr; Wolfgang Römer; W. Bautz; Raimund Forst; Torsten Kuwert; Andreas Mauerer