Markus Lankers
University of Jena
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Featured researches published by Markus Lankers.
Applied and Environmental Microbiology | 2005
Petra Rösch; Michaela Harz; Michael Schmitt; Klaus-Dieter Peschke; Olaf Ronneberger; Hans Burkhardt; Hans-Walter Motzkus; Markus Lankers; Stefan Hofer; Hans Thiele; Jürgen Popp
ABSTRACT Microorganisms, such as bacteria, which might be present as contamination inside an industrial food or pharmaceutical clean room process need to be identified on short time scales in order to minimize possible health hazards as well as production downtimes causing financial deficits. Here we describe the first results of single-particle micro-Raman measurements in combination with a classification method, the so-called support vector machine technique, allowing for a fast, reliable, and nondestructive online identification method for single bacteria.
Inorganica Chimica Acta | 1994
Gerhard Bringmann; Ulrich Dauer; Olaf Schupp; Markus Lankers; Jürgen Popp; Uwe Posset; Andrea Weippert; W. Kiefer
Semiempirical and ab initio calculations on the binding properties of the AlCl3 complex of 1,3-dimethylbenzo [b][naphtho[1,2-d]pyran-6-one are reported. Compounds of this type are key intermediates in the stereoselective synthesis of axially chiral biaryl systems. Semiempirical (MNDO, PM3) and ab initio (STO-3G, 3-21G) calculations give important information about conformational changes that occur by complexing the free lactone with AlCl3: the calculations predict a significant influence on the lengths of the (CO)exo and (CO)endo bonds, and a distinct planarization of the heterocyclic lactone part of the complexed benzonaphthopyranone. IR and Raman spectroscopy was applied in order to confirm the theoretical predictions. The good agreement of results obtained by semiempirical frequency calculations with the experimental data supports the assignment of vibrational bands affected on coordination. The highest shift caused by coordination (−152 cm−1) is observed for v(CO).
Biomedical optics | 2006
Petra Rösch; Michaela Harz; Michael Schmitt; Klaus-Dieter Peschke; Olaf Ronneberger; Hans Burkhardt; Hans-Walter Motzkus; Markus Lankers; Stefan Hofer; Hans Thiele; Jürgen Popp
A fast and unambiguous identification of microorganisms is necessary not only for medical purposes but also in technical processes such as the production of pharmaceuticals. Conventional microbiological identification methods are based on the morphology and the ability of microbes to grow under different conditions on various cultivation media depending on their biochemical properties. These methods require pure cultures which need cultivation of at least 6 h but normally much longer. Recently also additional methods to identify bacteria are established e.g. mass spectroscopy, polymerase chain reaction (PCR), flow cytometry or fluorescence spectroscopy. Alternative approaches for the identification of microorganisms are vibrational spectroscopic techniques. With Raman spectroscopy a spectroscopic fingerprint of the microorganisms can be achieved. Using UV-resonance Raman spectroscopy (UVRR) macromolecules like DNA/RNA and proteins are resonantly enhanced. With an excitation wavelength of e.g. 244 nm it is possible to determine the ratio of guanine/cytosine to all DNA bases which allows a genotypic identification of microorganisms. The application of UVRR requires a large amount of microorganisms (> 106 cells) e.g. at least a micro colony. For the analysis of single cells micro-Raman spectroscopy with an excitation wavelength of 532 nm can be used. Here, the obtained information is from all type of molecules inside the cells which lead to a chemotaxonomic identification. In this contribution we show how wavelength dependent Raman spectroscopy yields significant molecular information applicable for the identification of microorganisms on a single cell level.
Analytical Chemistry | 2006
Petra Rösch; Michaela Harz; Klaus-Dieter Peschke; Olaf Ronneberger; Hans Burkhardt; Andreas Schüle; Günther Schmauz; Markus Lankers; Stefan Hofer; Hans Thiele; Hans-Walter Motzkus; Jürgen Popp
ChemPhysChem | 2004
Ralph Gesner; C. Winter; Petra Rösch; Michael Schmitt; R. Petry; W. Kiefer; Markus Lankers; Juergen Popp
Archive | 2004
Hans Burkhardt; Stefan Hofer; Markus Lankers; Klaus-Dieter Peschke; R. Petry; Jürgen Popp; Olaf Ronneberger; Petra Rösch; Günther Schmauz; Andreas Schüle
ChemPhysChem | 2006
R. Petry; Remigius Mastalerz; Stefan Zahn; Thomas G. Mayerhöfer; Günther Völksch; Lothar Viereck-Götte; Birgit Kreher‐Hartmann; Lothar Holz; Markus Lankers; Jürgen Popp
Archive | 2004
Hans Prof. Dr. Burkhardt; Stefan Hofer; Markus Lankers; Klaus-Dieter Peschke; R. Petry; Jürgen Popp; Olaf Dipl.-Phys. Ronneberger; Petra Rösch; Günther Schmauz; Andreas Schüle
Archive | 2006
Lothar Holz; Markus Lankers; Georg Roessling
Archive | 2005
Lothar Holz; Oliver Valet; Markus Lankers