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Marlena Grynfarb

Novum

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Publication

Featured researches published by Marlena Grynfarb.

Bioorganic & Medicinal Chemistry Letters | 2003

An evaluation of a C-glucuronide as a liver targeting group: conjugate of a glucocorticoid antagonist.

Bryan K. Sorensen; James T. Link; Thomas W. von Geldern; Maurice Emery; Jiahong Wang; Bach Hickman; Marlena Grynfarb; Annika Goos-Nilsson; Sherry Carroll

A beta-C-glucuronide conjugate of the glucocorticoid receptor antagonist, Mifepristone 1, was prepared which maintained binding affinity, had modest in vitro activity, and was metabolically more stable than the parent. Pharmacokinetic studies suggest that the conjugate is recognized by the liver like O-glucuronides and may undergo a portion of the enterohepatic recirculation loop.

Journal of Pharmacology and Experimental Therapeutics | 2005

Hepatic glucocorticoid receptor antagonism is sufficient to reduce elevated hepatic glucose output and improve glucose control in animal models of type 2 diabetes.

Peer B. Jacobson; Thomas W. von Geldern; Lars Öhman; Marie Österland; Jiahong Wang; Bradley A. Zinker; Denise Wilcox; Phong Nguyen; Amanda K. Mika; Steven Fung; Thomas A. Fey; Annika Goos-Nilsson; Marlena Grynfarb; Tomas Barkhem; Kennan Marsh; David W. A. Beno; Bach Nga-Nguyen; Philip R. Kym; James T. Link; Noah Tu; Dale S. Edgerton; Alan D. Cherrington; Suad Efendic; Benjamin C. Lane; Terry J. Opgenorth

Journal of Medicinal Chemistry | 2004

Liver-Selective Glucocorticoid Antagonists: A Novel Treatment for Type 2 Diabetes.

Thomas W. von Geldern; Noah Tu; Philip R. Kym; James T. Link; Hwan-Soo Jae; Chunqiu Lai; Theresa Apelqvist; Patrik Rhönnstad; Lars Hagberg; Konrad Koehler; Marlena Grynfarb; Annika Goos-Nilsson; Johnny Sandberg; Marie Österlund; Tomas Barkhem; Marie Höglund; Jiahong Wang; Steven Fung; Denise Wilcox; Phong Nguyen; Clarissa G. Jakob; Charles W. Hutchins; Mathias Färnegårdh; Björn Kauppi; and Lars Öhman; Peer B. Jacobson

Bioorganic & Medicinal Chemistry Letters | 2004

Thyroid receptor ligands. Part 2: Thyromimetics with improved selectivity for the thyroid hormone receptor beta

Jon J. Hangeland; Arthur M. Doweyko; Tamara Dejneka; Todd J. Friends; Pratik Devasthale; Karin Mellström; Johnny Sandberg; Marlena Grynfarb; John S. Sack; Howard Einspahr; Mathias Färnegårdh; Bolette Husman; Jan Ljunggren; Konrad Koehler; Cheryl Sheppard; Johan Malm; Denis E. Ryono

Journal of Medicinal Chemistry | 2005

Antidiabetic activity of passive nonsteroidal glucocorticoid receptor modulators.

James T. Link; Bryan K. Sorensen; Jyoti Patel; Marlena Grynfarb; Annika Goos-Nilsson; Jiahong Wang; Steven Fung; Denise Wilcox; Brad Zinker; Phong Nguyen; Bach Hickman; James M. Schmidt; Sue Swanson; Zhenping Tian; Thomas Reisch; Gary Rotert; Jia Du; Benjamin C. Lane; and Thomas W. von Geldern; Peer B. Jacobson

Journal of Medicinal Chemistry | 2006

Thyroid receptor ligands. 6. A high affinity "direct antagonist" selective for the thyroid hormone receptor.

Konrad Koehler; Sandra Gordon; Peter Brandt; Bo Carlsson; Anna Bäcksbro-Saeidi; Theresa Apelqvist; Peter Agback; Gary J. Grover; William Nelson; Marlena Grynfarb; Mathias Färnegårdh; Stefan Rehnmark; Johan Malm

Journal of Medicinal Chemistry | 2005

Thyroid receptor ligands. 3. Design and synthesis of 3,5-dihalo-4-alkoxyphenylalkanoic acids as indirect antagonists of the thyroid hormone receptor.

Asa Hedfors; Theresa Appelqvist; Bo Carlsson; Lars-Göran Bladh; Chris Litten; Peter Agback; Marlena Grynfarb; Konrad Koehler; Johan Malm

Bioorganic & Medicinal Chemistry Letters | 2006

Thyroid receptor ligands. Part 5 : Novel bicyclic agonist ligands selective for the thyroid hormone receptor β

Ana-Maria Garcia Collazo; Konrad Koehler; Neeraj Garg; Mathias Färnegårdh; Bolette Husman; Liu Ye; Jan Ljunggren; Karin Mellström; Johnny Sandberg; Marlena Grynfarb; Harri Ahola; Johan Malm

Bioorganic & Medicinal Chemistry Letters | 2006

Thyroid receptor ligands. Part 4: 4'-amido bioisosteric ligands selective for the thyroid hormone receptor beta.

Yi-Lin Li; Chris Litten; Konrad Koehler; Karin Mellström; Neeraj Garg; Ana Maria Garcia Collazo; Mathias Färnegård; Marlena Grynfarb; Bolette Husman; Johnny Sandberg; Johan Malm

Bioorganic & Medicinal Chemistry Letters | 2004

Discovery of novel nonsteroidal glucocorticoid receptor modulators

James T. Link; Bryan K. Sorensen; Jyoti R. Patel; Maurice Emery; Marlena Grynfarb; Annika Goos-Nilsson

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Annika Goos-Nilsson

Novum

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Johnny Sandberg

Novum

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James T. Link

Icos

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Johan Malm

Novum

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Karin Mellström

Novum

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Konrad Koehler

Novum

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Bryan K. Sorensen

University of Pittsburgh

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Phong Nguyen

Cornell University

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Maurice Emery

Amgen

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Mathias Färnegårdh

Novum

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