Marta Guerrero

Issues to consider in the pharmaceutical development of a cardiovascular polypill

The pharmaceutical development of a cardiovascular polypill presents several unique challenges. The selection of the type and number of active drugs to be incorporated requires important consideration of clinical, pharmaceutical and commercial issues, and the final decision with regard to the polypills components depends on how these issues are prioritized. Once the drug combination has been chosen, developers must determine which pharmaceutical formulation should be used. The most appropriate method of drug delivery can vary markedly and depends on the characteristics of the drugs to be combined. Finally, careful consideration of how to gather the type of information required by regulatory agencies before a particular polypill can be approved for use in the general population is crucial. Although the association of multiple, active ingredients in a single dosage form would represent a major step forward in the prevention of cardiovascular conditions, a careful evaluation of all the above-mentioned variables and a well thought-out development plan is mandatory to maximize the chances of success.

AZOLE ADDITIONS UPON AZINIUM SALTS

Abstract The additions of pyrrole and indole upon N -acetyl- and N -alkylpyridinium, quinolinium or isoquinolinium salts are reported. The resulting dihydroazines are either isolated or oxidised to the more stable aromatic compounds. The use of a two-phase system was studied and slight enantiomeric excesses were observed when chiral catalysts were used. The separation of enantiomers of some 4-indolyl-1,4-dihydropyridines was achieved by HPLC using chiral stationary phases.

Las estrategias de implicación emocional en anuncios en prensa escrita alemana

Due to the increasing importance of emotionality in human decision-making pointed out in recent years from the emotional intelligence, this paper focuses on the presence of emotional aspects in a formal level in persuasive oriented texts such as advertising texts, and in particular in advertising texts in the German press. Thus, it has been carried out a qualitative analysis in order to codify indicators regarding emotionality. Those have been selected both from existing categories in the literature, as well from own developed categories. At that end, the final list of categories has been classified according to either the existing bound between participants (proximity/distance) or to the use of empathy. Therefore, it can be argued that the presence of emotional aspects reflects indisputable characteristics of a contemporary society focused on leisure and the emotional search.