Marta Legido

Fluoride ion mediated peterson alkenation of N-[C,C-bis(trimethylsilyl)methyl]amido derivatives with carbonyl compounds: a short general route to enamides and 1,2-dihydroisoquinolines.

Abstract A straightforward general access to diversely substituted acyclic or cyclic enamides and dienamides is accomplished by using a fluoride induced Peterson olefination of carbonyl compounds and enolizable amides derived from C,C-bis(trimethylsilyl) methylamine.

A novel highly stereoselective synthesis of pyrrolidines and their derivatives through thermal cyclization reaction of N-[bis(trimethylsilyl)methyl]-1-aza-1,3-dienes

The first example of the thermal intramolecular cyclization of N-[bis(trimethylsilyl)methyl]-1-aza-1,3-dienes to give 5-trimethylsilyl-Δ2-pyrrolines is reported; two straightforward and highly Stereoselective routes to 3,4-disubstituted-5-trimethylsilyl-Δ1pyrrolines and 3,4-disubstituted-2-trimethylsilylpyrrolidines are also described.

N-Methylidene(bis(trimethylsilyl)methyl)amine: the first isolable and stable monomeric methanimine allowing thermal (2 + 2) cycloadditions with ketenes

N-Methylidene[bis(trimethylsilyl)methyl]amine acts as a stable methanimine synthon [CH 2 NH] equivalent in [2 + 2] cycloadditions to ketenes, generated from acid chlorides and triethylamine, to provide 4-unsubstituted β-lactams in a single step.