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Postȩpy higieny i medycyny doświadczalnej | 2016

Immunological markers of rheumatoid arthritis

Agnieszka Matuszewska; Marta Madej; Piotr Wiland

Rheumatoid arthritis (RA) is the most common connective tissue disease of autoimmune origin. The disease is characterized by chronic inflammation leading to bone erosions and organ involvement. RA is a progressive disease. It affects the quality of life, leading to disability and death mainly due to premature cardiovascular disease. Early diagnosis and appropriate treatment are essential for prognosis and quality of life improvement. In 2010 the American College of Rheumatology (ACR) and The European League Against Rheumatism (EULAR) established new RA classification criteria. Besides clinical symptoms it includes two immunologic criteria: rheumatoid factor (RF) and anti-citrullinated protein antibodies (anti-CCP antibodies). RF is the first well-known RA immunologic marker. It is observed in 80-85% of patients with RA. Elevated serum level of RF has been associated with increased disease activity, radiographic progression, and the presence of extraarticular manifestations. The sensitivity of RF is 50-90%, and specificity is 50-95%. Anti-CCP antibodies appear to be a more specific marker than RF. They are often present at the very beginning of the disease, or even years before the first symptoms. The prognostic value of anti-CCP antibodies is well established. High serum level of anti-CCP correlates with poor prognosis and early erosions of the joints. The sensitivity of anti-CCP2 is 48-80%, and specificity is 96-98%. New immunologic markers include anti-carbamylated protein antibodies (anti-CarP) and antibodies against heterogeneous nuclear ribonucleoproteins (anti-hnRNP A2/B1, RA33). Scientists aim to identify a highly sensitive and specific biomarker of the disease that not only has diagnostic and prognostic value but also may predict the response to treatment.


Advances in Clinical and Experimental Medicine | 2016

The Activity of JAK/STAT and NF-κB in Patients with Rheumatoid Arthritis.

Jerzy Świerkot; Beata Nowak; Anna Czarny; Ewa Zaczyńska; Renata Sokolik; Marta Madej; Lucyna Korman; Agata Sebastian; Patryk Wojtala; Łukasz Lubiński; Piotr Wiland

BACKGROUND Research is still being conducted in order to determine the mechanisms responsible for the initiation of rheumatoid arthritis (RA) as well as for its persistence and progression. OBJECTIVES The aim of this work was to establish the expression of the signal transducer and activator of transcription (STAT) transcription factors and the nuclear factor kappa-light-chain-enhancer of activated B cells (NFκB) transcription factor in peripheral blood leukocytes and synovial fluid cells. The correlations between the activation level of the transcription factors and the activity of the disease were also analyzed. MATERIAL AND METHODS In total, the study included 34 RA patients and 19 healthy individuals as controls. The expression of NFκB, STAT1, STAT3, STAT4, STAT5 and STAT6 in peripheral blood leukocytes and synovial fluid cells was established. The immunocytochemistry method was used to determine the degree of activation of STAT and NF-κB transcription factors. For the location of the factors, primary polyclonal anti-STATs and monoclonal anti-NF-κB antibodies were used. RESULTS The expression of STAT1, STAT3, STAT4, STAT5, STAT6 and NFκB was significantly higher in the group of RA patients than in the controls. No statistically significant differences were found between the expression of STATs in peripheral blood leukocytes and synovial fluid cells. CONCLUSIONS In comparison with the control group, the expression of the STAT and NFκB transcription factors in RA patients was higher, which may be helpful in better understanding the etiopathogenesis of the disease in the future, and may potentially have important therapeutic implications.


Reumatologia | 2015

Cytokine profiles in axial spondyloarthritis.

Marta Madej; Beata Nowak; Jerzy Świerkot; Renata Sokolik; Arkadiusz Chlebicki; Lucyna Korman; Patryk Woytala; Łukasz Lubiński; Piotr Wiland

Objectives Current studies concentrate on the cytokine network and its role in the pathogenesis of spondyloarthritis (SpA). In this study, we analyzed whether the serum cytokine profile (interleukins: IL-10, IL-11, IL-12, IL-15, IL-17, IL-23 and IL-33) correlates with demographic data, clinical manifestations, disease activity and treatment outcome in a group of patients with axial spondyloarthritis. Material and methods Forty-nine patients with an established diagnosis of axial spondyloarthritis (aSpA) and 19 healthy volunteers as controls were enrolled in the study. Clinical evaluation included patients medical history, 44 joint count, back pain intensity and global disease activity in the preceding week (VAS), the duration of morning stiffness and blood tests. Disease activity was assessed using BASDAI and ASDAS-CRP. Serum concentration of IL-10, IL-11, IL-12, IL-15, IL-17, IL-23 and IL-33 was determined. Results In patients with aSpA, elevated serum concentration of IL-10, IL-15, IL-17 and IL-23 was detected. In the aSpA group we detected higher values of serum concentration of IL-23 and IL-33 in the subgroup with anterior uveitis (83.1 ±184.0 pg/ml vs. 14.0 ±17.1 pg/ml, p < 0.0001 and 45.5 ±71.9 pg/ml vs. 18.4 ±14.3 pg/ml, p < 0.0001, respectively). Additionally, in the subgroup with peripheral arthritis, elevation of serum concentration of IL-12 (249.3 ±246.9 pg/ml vs. 99.9 ±105.9 pg/ml, p = 0.0001) was detected. Patients with preradiological SpA had higher serum concentration of IL-17 than patients with established diagnosis of AS (6.37 ±8.50 pg/ml vs. 2.04 ±2.98 pg/ml, p = 0.0295). No differences in serum concentration of analyzed cytokines were found between the subgroup with low to moderate disease activity and the subgroup with high to very high disease activity. Conclusions We report that in aSpA patients, compared to controls, elevated serum concentrations of IL-10, IL-15, IL-17 and IL-23 were observed. Some cytokines may predispose to a more severe course of aSpA.


Advances in Clinical and Experimental Medicine | 2016

Disease Activity, Oxidized-LDL Fraction and Anti-Oxidized LDL Antibodies Influence Cardiovascular Risk in Rheumatoid Arthritis.

Beata Nowak; Marta Madej; Anna Łuczak; Rafał Małecki; Piotr Wiland


Reumatologia News | 2017

Zalecenia, zasady prowadzenia leczenia reumatoidalnego zapalenia stawów glikokortykosteroidami

Jerzy Świerkot; Marta Madej


Reumatologia News | 2017

Optymalizacja leczenia klasycznymi lekami modyfikującymi przebieg choroby

Jerzy Świerkot; Marta Madej


Reumatologia News | 2016

Ziarniniakowatość z zapaleniem naczyń - problemy diagnostyczne?

Marta Madej; Agnieszka Matuszewska; Katarzyna Białowąs; Piotr Wiland


Reumatologia | 2014

Granulomatosis with polyangiitis – diagnostic difficulties?

Marta Madej; Agnieszka Matuszewska; Katarzyna Białowąs; Piotr Wiland


Reumatologia | 2014

Clinical forms of granulomatosis with polyangiitis

Marta Madej; Agnieszka Matuszewska; Katarzyna Białowąs; Piotr Wiland


Archive | 2014

Clinical forms of granulomatosis with polyangiitis Postacie kliniczne ziarniniakowatości z zapaleniem naczyń

Marta Madej; Agnieszka Matuszewska; Katarzyna Białowąs; Piotr Wiland

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Piotr Wiland

Wrocław Medical University

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Beata Nowak

University of Wrocław

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Anna Czarny

Polish Academy of Sciences

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Jerzy Świerkot

Wrocław Medical University

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Lucyna Korman

Wrocław Medical University

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Renata Sokolik

Wrocław Medical University

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Agata Sebastian

Wrocław Medical University

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