Martelia Bell

Further studies on formate incorporation by leukemic blood cells.

Summary Experiments have been carried out which demonstrate that leukemic cells immobilized in a cellophane bag implanted in the abdominal cavity of a host mouse incorporate C14-formate much more rapidly than do normal lymphocytes.

Preferential incorporation of formate carbon into leukemic blood cells as indicated by autoradiography.

Summary At one hour after injection of 100,μc of C14-formate into mice with advanced Ak-4 leukemia, it has been shown by means of blood smear autoradiograms that about 90% of the leukemic cells are highly active as compared to about 5% of the more mature lymphoid elements. No active polymorphonuclears, erythrocytes, or thrombocytes were observed within one hour.

Long-Term Radiation of Bone Following Administration of C14-Bicarbonate.

Summary Studies have been carried out on retention of C14 from labeled bicarbonate in the bones of mice. A single dose of 100 μc per mouse (a 280 millicurie man-equivalent) provided daily radiation of the most active areas of the long bones of above 0.05 rep/ day for a period of approximately one year.