Martha Laura Ramírez-Montiel

The Combination of Naproxen and Citral Reduces Nociception and Gastric Damage in Rats

It has been shown that the association of non-steroidal anti-inflammatory drugs with plant extracts can increase their antinociceptive activity, allowing the use of lower doses and, thus, limiting side effects. Therefore, the aim of this study was to examine the effects of the interaction between naproxen and citral on nociception and gastric injury in rats. Naproxen, citral, or combinations of naproxen and citral produced an antinociceptive effect. The administration of naproxen produced significant gastric damage, but this effect was not obtained with either citral or the naproxen-citral combination. The ED50 value was estimated for the individual drugs and an isobologram was constructed. The derived theoretical ED50 for the antinociceptive effect (423.8 mg/kg) was not significantly different from the observed experimental value (359.0 mg/kg); hence, the interaction between naproxen and citral mediating the antinociceptive effect is additive. These data suggest that the naproxen-citral combination interacts at the systemic level, produces minor gastric damage, and potentially has therapeutic advantages for the clinical treatment of inflammatory pain.

Pelvic packing with vaginal traction for the management of intractable hemorrhage

To present clinical cases examining the effectiveness and safety of pelvic packing with vaginal traction for inhibiting obstetric hemorrhage among women receiving treatment at a public obstetrics and gynecology tertiary care hospital in Mexico.

265 EXAMINATION OF THE INTERACTION BETWEEN NAPROXEN AND CITRAL ON NOCICEPTION, INFLAMMATION AND GASTRIC DAMAGE IN RATS

263 LONGITUDINAL NUMBERS-NEEDED-TO-TREAT (NNT) ANALYSES OF ANALGESIC TREATMENTS FOR CHRONIC LOW BACK PAIN TO ACHIEVE VARYING RESPONSE LEVELS AND STABILITY T.J. Schnitzer, R.A. Moore, N.P. Katz, A. Gammaitoni *, A. Mehta, H. Wang, P. Peloso. Physical Medicine and Rehabilitation, Northwestern University Feinberg School of Medicine, Chicago, United States; Pain Research, Nuffield Department of Anaesthetics, Oxford, United Kingdom; Clinical Research, Analgesic Research, Needham, United States; Merck Research Laboratories, Rahway, United States