Martin Gough

Short-term outcome of multilevel surgical intervention in spastic diplegic cerebral palsy compared with the natural history.

Outcome in 24 ambulant children with spastic diplegic cerebral palsy, in whom multilevel surgical intervention was recommended following gait analysis, is reviewed. Twelve children had surgical intervention (treatment group; eight males, four females; mean age 9 years 10 months, SD 3 years 4 months) while the other 12 did not (control group; five males, seven females; mean age 10 years 1 month, SD 2 years 11 months). All children had interval three-dimensional gait analyses (mean time between analyses: control group, 14.1 months; treatment group, 17.9 months). At follow-up the control group (mean age 11 years 9 months) showed a significant increase in minimum hip and knee flexion in stance which was not related to age, the interval between analyses, changes in the passive joint range of motion, nor changes in anthropometric measurements. The treatment group (mean age at follow-up 11 years 3 months) showed a significant improvement in minimum knee flexion and in ankle dorsiflexion in stance. Parents of nine children said their childs walking distance had increased following intervention. Of five children using posterior walkers preoperatively, two continued to use them postoperatively; two were using crutches or sticks and the remaining child walked independently. Two children who walked independently preoperatively used sticks postoperatively for community ambulation. The deterioration seen in the kinematics of the control group suggests that previous outcome studies comparing postoperative gait with preoperative gait have underestimated the immediate effects of surgery. It also raises concerns about the long-term effects of surgical intervention.

Changes in the Volume and Length of the Medial Gastrocnemius After Surgical Recession in Children With Spastic Diplegic Cerebral Palsy

Background: Morphology is an important determinant of muscle force and power generation. Children with spastic diplegic cerebral palsy (SDCP) have reduced muscular strength, which in part is caused by inadequate muscle growth. There is a widespread concern that surgery to correct soft tissue deformities may exacerbate the underlying muscle weakness and further retard muscle growth. In this study, we compared measurements of medial gastrocnemius (MG) muscle morphology in typically developing (TD) children to those in children with SDCP with calf muscle deformities before and after corrective surgery. Methods: We measured the length and volume of the MG muscle belly using 3-dimensional ultrasound immediately before and at 7 weeks and 1 year after vulpius procedure (VP) surgery in children with SDCP. We made similar measurements in a group of TD children. The SDCP group consisted of 7 children (6 boys, 1 girls; total of 8 limbs; age range, 6-10 years; mean 8 years 1 month, SD ± 1 year 11 months) and the TD group consisted of 10 children (4 boys, 6 girls; age range, 6-12 years; mean, 9 years 5 months; SD ± 2 years 6 months). Results: The children with SDCP presented with MG muscle bellies both smaller and shorter than the TD children even when normalized to body mass and limb length, respectively. Muscle belly length was reduced by surgery and remained unaltered 1 year later, despite skeletal growth. Muscle volume was not significantly changed 7 weeks after surgery, but increased significantly between 7 weeks and 1 year after surgery. Conclusions: Children with SDCP presented with short and small MG when compared with TD children. Our results indicate that gastrocnemius muscle volume recovers within a year of VP surgery. Clinical Relevance: This study is the first to investigate the effects of surgery on muscle belly volume and length in the human subject. The study indicates that VP surgery is not an agent of long-term muscle atrophy in individuals with SDCP with plantarflexion deformities.

Could muscle deformity in children with spastic cerebral palsy be related to an impairment of muscle growth and altered adaptation

Skeletal muscle deformity is common in children with spastic cerebral palsy (CP), but the underlying mechanisms are unclear. This review explores some possible factors which may influence the development of muscle deformity in CP. Normal muscle function and growth appear to depend on the interaction of neuronal, endocrinal, nutritional, and mechanical factors, and also on the development of an appropriate balance between muscle protein synthesis and degradation, and between the development of contractile and non‐contractile components. In this context, the changes seen in muscle in children with CP are reviewed and discussed. It is suggested that the development of muscle deformity in children with CP may be related to a multifactorial impairment of muscle growth, on which adaptation of the extracellular matrix due to altered loading may be imposed.

Lower limb muscle volumes in bilateral spastic cerebral palsy.

AIM Muscle weakness is a feature of individuals with spastic cerebral palsy (SCP) but there are few reports in the literature of muscle volume in this group. This study compares muscle volumes in adolescents and young adults with SCP with those of their typically developing (TD) peers. DESIGN Measurements of the volumes of nine major lower limb muscles in 19 independently ambulant subjects with SCP (mean age 14.2 years (sd 2.7), 11 male, GMFCS I (n=5); GMFCS II (n=14)), 19 TD subjects (mean age 16.5 years (sd 3.0), 11 male) were made using magnetic resonance imaging. RESULTS Lower limb muscles were smaller in the SCP group (p≤0.023 in all muscles) than the TD group with the exception of the vastii (lateralis+intermedius; p=0.868) and gluteus maximus (p=0.056). Average muscle volume deficit was 27.9%. Muscle volume deficits were significantly greater for distal muscles than proximal muscles (p<0.001). CONCLUSIONS Reduced muscle size in adolescence and the natural history of sarcopenia in adulthood may contribute to the early loss of mobility of adults with SCP.

Continuous postural management and the prevention of deformity in children with cerebral palsy: an appraisal.

Continuous postural management programmes are commonly used for children with cerebral palsy (CP) in Gross Motor Function Classification System levels IV and V, with the aim of preventing musculoskeletal deformity. There is a lack of evidence to support their use in this capacity and a possibility that children with CP who are most likely to develop deformity may be least able to comply with a continuous postural management programme. The implications for the child and family of such a programme in terms of increased demands and potential discomfort are discussed within the framework of the International Classification of Functioning, Disability and Health. A shift in focus in the use of postural management from an emphasis on body structure towards the environment and participation of the child with CP is suggested.

Can clinical gait analysis guide the management of ambulant children with bilateral spastic cerebral palsy

Background: The role of clinical gait analysis in the management of ambulant children with bilateral spastic cerebral palsy (BSCP) is controversial. We hypothesized that gait analysis would allow us to differentiate between children with BSCP who would benefit from surgical intervention and those in whom surgery was not indicated. Methods: We reviewed the outcome in 3 groups of children with BSCP referred for treatment recommendations based on gait analysis by looking at changes in the popliteal angle (PA), Gillette Gait Index (GGI), and minimum knee flexion in single support (MKFS) on a subsequent gait analysis. We identified 15 children in whom surgical intervention was not thought to be needed (SNR group) and 15 children who had multilevel surgery recommended but not performed (SND group). We randomly selected and reviewed 15 children referred during the study period who had multilevel surgery recommended and performed following gait analysis (OP group) for comparison. Results: The initial PA, MKFS, and GGI were greater in the OP and SND groups compared with the SNR group. Popliteal angle did not change between analyses in the SNR and SND groups and decreased in the OP group (P = 0.004). Minimum knee flexion in single support remained similar between analyses in the SNR group, increased in the SND group (P < 0.0001), and decreased in the OP group (P < 0.0001). The GGI remained similar in the SNR and SND groups but decreased in the OP group (P = 0.0002). The number of children in the SND group showing an increase of more than 10% in the GGI between analyses (8/15) was greater than that in the OP group (0/15) (P = 0.0022). The PA, MKFS, and GGI contributed significantly to the treatment recommendations (P = 0.0013, P = 0.0045, P = 0.0054, respectively), which were not affected by age and Gross Motor Functional Classification System level. Conclusions: Gait analysis helped us to distinguish children with BSCP who would benefit from surgery from those in whom nonoperative management was appropriate, and its routine clinical use is encouraged in the management of these children. Level of Evidence: Level III, retrospective comparative study.

Does sex influence outcome in ambulant children with bilateral spastic cerebral palsy

To investigate the effect of sex on the phenotype of bilateral spastic cerebral palsy (CP) we reviewed the gait analysis data of 116 children (78 males, mean age 8y 1mo [SD 3y 1mo] and 38 females, mean age 8y 9mo [3y 1mo]) with bilateral spastic CP (Gross Motor Function Classification System [GMFCS] Levels I [four males, six females]; II [41 males, 19 females]; III [26 males, 12 females]; and IV [7 males, 1 female]) who had been referred for gait analysis to inform treatment. Although there were no differences between males and females in terms of gestational age, chronological age, or GMFCS level, males were more likely to have had nonoperative intervention before the referral (p=0.024), had a greater degree of knee flexion in stance phase when walking (p=0.003), and had a higher Gillette Gait Index (p<0.001) when compared with females. Males were also more likely to have surgery recommended on the basis of gait analysis (p<0.001). Sex seems to influence the development of the musculoskeletal system and mobility in ambulant children with bilateral spastic CP, and this may need to be considered when planning intervention or when assessing the outcome of intervention.

Bone strength is related to muscle volume in ambulant individuals with bilateral spastic cerebral palsy

OBJECTIVE The aim of this study is to investigate how bone strength in the distal femur and proximal tibia are related to local muscle volume in ambulant individuals with bilateral spastic cerebral palsy (CP). METHODS Twenty-seven participants with CP (mean age: 14.6±2.9years; Gross Motor Function Classification System (GMFCS) levels I-III) and twenty-two typically developing (TD) peers (mean age: 16.7±3.3years) took part in this study. Periosteal and medullary diameter in the distal femur and cortical bone cross-sectional area (CSA) and thickness (CT) in the distal femur and proximal tibia were measured along with nine lower limb muscle volumes using MRI. Additionally, the polar section modulus (Zp) and buckling ratio (BR) were calculated to estimate bone bending strength and compressional bone stability respectively in the distal femur. The relationships of all measured parameters with muscle volume, height, age, body mass, gender, and subject group were investigated using a generalized linear model (GZLM). RESULTS In the distal femur, Zp was significantly positively related to thigh muscle volume (p=0.007), and height (p=0.026) but not significantly related to subject group (p=0.076) or body mass (p=0.098). BR was not significantly different between groups and was not related to any of the variables tested. Cortical bone CSA was significantly lower in the CP group at both the distal femur (p=0.002) and proximal tibia (p=0.009). It was also positively associated with thigh muscle volume (p<0.001) at the distal femur, and with subject height (p=0.005) at the proximal tibia. CONCLUSIONS Bending and compressional strength of the femur, estimated from Zp and cortical bone CSA respectively, is associated with reduced thigh muscle volume. Increasing muscle volume by strength training may have a positive effect on bone mechanics in individuals with CP.

Selective motor control correlates with gait abnormality in children with cerebral palsy

Children with bilateral cerebral palsy (CP) commonly have limited selective motor control (SMC). This affects their ability to complete functional tasks. The impact of impaired SMC on walking has yet to be fully understood. Measures of SMC have been shown to correlate with specific characteristics of gait, however the impact of SMC on overall gait pattern has not been reported. This study explored SMC data collected as part of routine gait analysis in children with bilateral CP. As part of their clinical assessment, SMC was measured with the Selective Control Assessment of the Lower Extremities (SCALE) in 194 patients with bilateral cerebral palsy attending for clinical gait analysis at a single centre. Their summed SCALE score was compared with overall gait impairment, as measured by Gait Profile Score (GPS). Score on SCALE showed a significant negative correlation with GPS (rs=-0.603, p<0.001). Cerebral injuries in CP result in damage to the motor tracts responsible for SMC. Our results indicate that this damage is also associated with changes in the development of walking pattern in children with CP.

Serial casting in cerebral palsy : panacea, placebo, or peril?

an equinus gait. The effect of prolonged immobilization and stretch on developing human calf muscle morphology is not known, and is likely to be influenced by the duration and intensity of stretch. In children with CP, casting of calf muscles may exacerbate their altered morphology. Although excessive lengthening is an obvious concern, it is possible that even casting which does not result in an overall change in MTU length could still be associated with a deleterious shift in muscle belly:tendon length ratio with a reduction in the ability to store and release elastic energy, resulting in a potentially damaging increase in eccentric loading in an already weak muscle. The popularity of serial casting may be related to its ease of application, apparent lack of significant adverse effects, and to the perceived opportunity to do something helpful for the child with CP. More evidence is needed, however, about the effect of casting on muscle morphology to define whether the limited short-term benefit is associated with a long-term benefit or detriment in terms of mobility and function for the child with CP.