Network


Latest external collaboration on country level. Dive into details by clicking on the dots.

Hotspot


Dive into the research topics where Martin McCarthy is active.

Publication


Featured researches published by Martin McCarthy.


Ophthalmology | 1994

Idiopathic Sclerosing Inflammation of the Orbit: A Distinct Clinicopathologic Entity

Jack Rootman; Martin McCarthy; Valerie A. White; Gerald J. Harris; John S. Kennerdell

BACKGROUND Idiopathic sclerosing inflammation of the orbit is a poorly delineated, fibrosing, immune-mediated entity resulting in significant ocular disability. To characterize this process and propose more specific and effective therapy, clinical and pathologic findings in 16 cases are reviewed. METHODS The clinical records of 16 patients with biopsy-proven disease were retrospectively reviewed to determine demographic and clinical features, radiologic features, course, management, and outcome. These findings were correlated with pathologic features to describe this unique entity. Immunohistologic characteristics were compared with those of a clinically and histopathologically similar process, retroperitoneal fibrosis. RESULTS The study included 11 male and 5 female patients, ranging in age from 8 to 81 years. Disease onset was usually unilateral (14/16) and chronic (11/15), with two distinct anatomic presentations, lacrimal (11/16) and apical (3/16), characterized by infiltration (15/16), mass effect (12/16), and visual loss (3/16). The most common signs and symptoms were dull pain (13/16), proptosis (11/16), mild inflammation (11/16), restricted motility (9/16), swelling (9/16), and diplopia (8/16). Two features, a sparse, chronic inflammatory infiltrate, the immunopathologic characteristics of which suggested a cell-mediated process, and a desmoplastic stroma of early onset, dominated the pathologic picture. Treatment with corticosteroids (11/16), radiotherapy for steroid failures (8/11), and observation alone (3/16) was inadequate, resulting in blindness in 3/16 cases, restricted movement in 10/16, and complete resolution in only 2/16 patients. CONCLUSION Idiopathic sclerosing inflammation of the orbit is a unique clinicopathologic entity, similar to retroperitoneal fibrosis, that is characterized by primary, chronic, and immunologically mediated fibrosis, poor response to corticosteroid treatment or radiotherapy, and frequent visual disability. Early and aggressive immunosuppressive therapy is recommended.


Journal of Refractive Surgery | 2011

Artiflex Phakic Intraocular Lens Implantation After Corneal Collagen Cross-linking in Keratoconic Eyes

Luis Izquierdo; Maria A Henriquez; Martin McCarthy

PURPOSE To evaluate the safety, efficacy, and stability of the Artiflex (Ophtec BV) foldable anterior iris-claw phakic intraocular lens (PIOL) following corneal collagen cross-linking (CXL) in select cases of progressive keratoconus. METHODS This prospective, comparative study, conducted between March 2007 and June 2008, involved 11 eyes with progressive keratoconus. Inclusion criteria were progressive keratoconus (Amsler-Krumeich classification grades I and II) with no corneal opacities, corneal thickness >450 μm, endothelial cell count >2500 cells/mm(2), anterior chamber depth >3.2 mm, spherical equivalent refraction >4.50 diopters (D) (with a cylinder component <2.00 D), and no other treatment for keratoconus other than contact lens. Each patient underwent CXL in the keratoconic eye with implantation of the Artiflex IOL 6 months thereafter. Uncorrected distance visual acuity (UDVA), corrected distance visual acuity (CDVA), and refraction and topographic profiles were examined at 1, 6, and 12 months after the CXL procedure. RESULTS All eyes achieved UDVA of 0.3 logMAR or better. Final spherical and cylindrical error ranged from 0 to -1.50 D and 0 to -1.75 D, respectively. No eyes lost lines of preoperative CDVA. Statistically significant reductions in mean maximum (2.14 D, P<.001) and minimum (1.17 D, P=.02) keratometry values were present 12 months after the CXL procedure. No complications were observed. CONCLUSIONS Combined CXL and Artiflex implantation was a safe and effective treatment in this subset of eyes with progressive keratoconus. Good results in terms of visual acuity, postoperative residual refractive error, and keratometry values were identified.


Cornea | 2014

Evolving indications for and trends in keratoplasty in British Columbia, Canada, from 2002 to 2011: a 10-year review.

Johnson C. H. Tan; Simon Holland; Paul Dubord; Gregory Moloney; Martin McCarthy; Sonia N. Yeung

Purpose: The aim of this study was to report the evolving indications for keratoplasty and the shift in the type of keratoplasty performed in British Columbia, Canada, over a 10-year period from 2002 to 2011. Methods: This was a retrospective database review of all the records of corneal transplant tissues at the Eye Bank of British Columbia, Canada, from January 2002 to December 2011. The patient demographics, indications, and types of transplant performed were analyzed. Results: A total of 4843 corneal transplants were performed in 3742 patients (1968 male and 1774 female) from January 2002 to December 2011. The number of keratoplasties performed ranged from 420 in 2008 to 578 in 2011. The top 4 indications over the 10-year period were Fuchs endothelial dystrophy (FED; 18.9%), aphakic/pseudophakic bullous keratopathy (17.4%), regraft (17.1%), and keratoconus (15.5%). Penetrating keratoplasty (PKP) accounted for 86.5% (4191 transplants) of all keratoplasties performed. Since the introduction of Descemet stripping automated endothelial keratoplasty (DSAEK) in 2007, there was a significant increase in the number of DSAEKs (P < 0.0001) performed and a statistical decline in the number of PKPs (P < 0.0001) performed. Despite only 30 deep anterior lamellar keratoplasties being performed, an increasing trend was observed after 2008 (P = 0.0087). A decreasing trend in PKPs and an increasing trend in DSAEKs were observed for surgeries performed for FED, aphakic/pseudophakic bullous keratopathy, and regraft. Conclusions: FED has become the top indication for performing a keratoplasty over the 10-year period. There was a shift from PKP to DSAEK performed for endothelial failure. Although the number of deep anterior lamellar keratoplasty surgeries was small, there was a significant increasing trend.


Ophthalmology | 1994

Panstromal Schnyder corneal dystrophy. A clinical pathologic report with quantitative analysis of corneal lipid composition.

Martin McCarthy; Sheila M. Innis; Paul Dubord; Valerie A. White

BACKGROUND The pathogenesis of Schnyder dystrophy is thought to be a primary abnormality of corneal lipid metabolism resulting in opacification secondary to lipid accumulation. Histochemical investigations have suggested the accumulated lipid includes unesterified cholesterol; however, quantitative analysis has not been done. METHODS Quantitative biochemical analysis was performed on a corneal button obtained from a patient with clinically and pathologically proven Schnyder dystrophy. Results were compared with four age-, sex-, and size-matched corneal buttons obtained from cadaveric eyes. RESULTS Corneal lipid accumulated in Schnyder dystrophy predominantly is composed of phospholipid, free cholesterol, and cholesterol ester. These constituents were markedly elevated in the Schnyder cornea when compared with cadaveric control corneas as follows: (1) phospholipid, 23.6 versus 4.05 mg/g; (2) unesterified cholesterol, 6.99 versus 0.52 mg/g; and (3) cholesterol ester, 3.16 versus 0.26 mg/g. CONCLUSION Phospholipid, unesterified cholesterol and cholesterol ester are the predominant lipids in Schnyder dystrophy. The pathogenesis may be a primary disorder of corneal lipid metabolism.


Current Medical Research and Opinion | 2007

The ocular penetration of levofloxacin 1.5% and gatifloxacin 0.3% ophthalmic solutions in subjects undergoing corneal transplant surgery

Edward J. Holland; Martin McCarthy; Simon Holland

ABSTRACT Objective: To compare corneal tissue and aqueous humor concentrations of levofloxacin 1.5% and gatifloxacin 0.3% ophthalmic solutions after topical dosing. Research design and methods: This was a randomized, observer-masked, parallel-group, multicenter study. Fifty-nine subjects undergoing planned penetrating keratoplasty were randomly assigned to receive either levofloxacin 1.5% or gatifloxacin 0.3% as follows: one drop 15 min prior to surgery and a second drop 10 min before surgery. Corneal button and aqueous humor samples were collected during surgery and immediately stored at –70 °C. Levofloxacin and gatifloxacin concentrations were determined by high-pressure liquid chromatography and mass spectrometry. Main outcome measures: Corneal tissue and aqueous humor concentrations of levofloxacin and gatifloxacin. Results: Levofloxacin achieved statistically significantly higher concentrations in both corneal tissue and aqueous humor compared to gatifloxacin in patients undergoing penetrating keratoplasty. In corneal tissue the mean concentration of levofloxacin was 64.8 ± 123.4 µg/g vs. 7.0 ± 9.3 µg/g for gatifloxacin (p < 0.0001). Mean aqueous humor concentration of levofloxacin was 0.976 ± 2.215 µg/mL vs. 0.0523 ± 0.143 µg/mL for gatifloxacin (p = 0.0002). Conclusions: The high concentrations of levofloxacin achievable in corneal tissue with topical dosing suggest that levofloxacin 1.5% should be a useful agent in the treatment of ocular bacterial infections. However, the corneal concentrations achieved in this study may not be representative of concentrations in patients using less frequent dosing.


Cornea | 2012

Corneal collagen cross-linking before Ferrara intrastromal corneal ring implantation for the treatment of progressive keratoconus.

Maria A Henriquez; Luis Izquierdo; Cesar Bernilla; Martin McCarthy

Purpose: To evaluate the safety, efficacy, and stability of sequential corneal collagen cross-linking (CXL) and Ferrara intrastromal corneal ring segment (FR) implantation in selected patients with progressive keratoconus. Methods: This prospective study involved 9 eyes with progressive keratoconus and a preoperative cylinder value equal to or greater than 5 diopters (D) diagnosed between June 2007 and October 2008. Preoperative and postoperative (6 months after the CXL procedure and 6 months after the FR implantation) biomicroscopy examinations, distance uncorrected and best-corrected visual acuities, refractive error, and topographic maps were evaluated and compared. Results: Mean uncorrected visual acuity was 1.11 logarithm of the minimal angle of resolution (logMAR) preoperatively and 0.75 logMAR at 6 months after CXL (P = 0.03) and 0.23 logMAR at 6 months after FR implantation (P < 0.001). Mean best-corrected visual acuity was 0.26 logMAR preoperatively and 0.24 logMAR at 6 months after CXL (P = 0.87) and 0.12 logMAR at 6 months after FR (P = 0.05). Statistically significant reductions in the mean spherical equivalent (4.38 D; P < 0.001) and mean maximum (5.58 D; P < 0.001) and minimum (4.17 D; P < 0.001) keratometry values were present at 6 months after FR. Conclusions: FR implantation after CXL is a safe and efficacious treatment option for managing selected patients with progressive keratoconus. Good results in terms of visual acuity, postoperative residual refractive error, and keratometry values were obtained. Longer follow-up would be valuable to confirm the stability of these results.


Cornea | 2016

Corneal Cross-Linking in Pediatric Patients With Progressive Keratoconus.

Stephanie J. Wise; Christian Diaz; Karolien Termote; Paul Dubord; Martin McCarthy; Sonia N. Yeung

Purpose: To evaluate corneal cross-linking (CXL) in the treatment of keratoconus in pediatric patients. Specifically, this study investigates the impact of CXL on uncorrected distance visual acuity (UDVA), best-corrected distance visual acuity (BDVA), manifest refraction, keratometry (K) measurements, and higher order aberrations. Methods: This is a retrospective, observational case series of patients 18 years old or younger with progressive keratoconus who underwent CXL from January 2009 to August 2013. Preoperative and 1-year postoperative data including BDVA, manifest refraction, mean K readings, and corneal aberration measurements were extracted from clinical charts and topographical imaging. Visual acuity was converted to logarithm of the minimum angle of resolution (logMAR) scale, and mean refractive spherical equivalent (MRSE) was calculated from manifest refraction. Results: The group consisted of 39 eyes from 28 patients, including 21 males and 7 females (mean age = 16.3 years, range: 11–18, standard deviation [SD] = 1.81). UDVA did not change significantly (preoperative UDVA = 1.20 logMAR, SD = 0.57, and postoperative UDVA = 0.90 logMAR, SD = 0.67, P = 0.19). BDVA did not change significantly (preoperative BDVA = 0.34 logMAR, SD = 0.27, and postoperative BDVA = 0.34 logMAR, SD = 0.23, P = 0.50). There was no significant change in mean K (preoperative K = 48.49, SD = 5.44, and postoperative K = 48.25, SD = 4.74, P = 0.34). Mean MRSE did not change significantly (preoperative MRSE = −3.29 D, SD = 4.04, and postoperative MRSE = −3.53 D, SD = 4.07, P = 0.31). Corneal aberration measurements were available for 10 eyes, and stability of measurements was demonstrated. There were no complications noted. Conclusions: This study suggests that CXL is a safe and effective procedure that halts the progression of keratoconus in pediatric patients at 1-year follow-up. To validate these findings, longer follow-up is required.


Ophthalmic Surgery Lasers & Imaging | 2011

Double Aspiration/Single Irrigation System for Bimanual Lens Cortex Removal in Cataract Surgery

Luis Izquierdo; Maria A Henriquez; Martin McCarthy

The authors describe a bimanual double aspiration/single irrigation system (DASIS) for cataract surgery that efficiently and safely performs aspiration of the entire cortex, including subincisional space. DASIS uses standard and common instruments such as an irrigation/aspiration handpiece in one hand and a single-aspiration handpiece in the other, joined with a short silicone tube using a three-way stopcock. DASIS allows access to 360° of the cortex without a hand exchange, reducing wound leakage and maintaining chamber stability.


Ophthalmology | 2011

Intraocular Lens Power Calculations after Myopic Laser Refractive Surgery: A Comparison of Methods in 173 Eyes

Martin McCarthy; Gregory M. Gavanski; Katherine Paton; Simon Holland


Ophthalmology | 1994

Idiopathic Sclerosing Inflammation of the Orbit

Jack Rootman; Martin McCarthy; Valerie A. White; Gerald J. Harris; John S. Kennerdell

Collaboration


Dive into the Martin McCarthy's collaboration.

Top Co-Authors

Avatar

Paul Dubord

University of British Columbia

View shared research outputs
Top Co-Authors

Avatar

Simon Holland

University of British Columbia

View shared research outputs
Top Co-Authors

Avatar

Valerie A. White

University of British Columbia

View shared research outputs
Top Co-Authors

Avatar

Luis Izquierdo

University of California

View shared research outputs
Top Co-Authors

Avatar

Jack Rootman

University of British Columbia

View shared research outputs
Top Co-Authors

Avatar

Sonia N. Yeung

University of British Columbia

View shared research outputs
Top Co-Authors

Avatar

Gerald J. Harris

Medical College of Wisconsin

View shared research outputs
Top Co-Authors

Avatar
Top Co-Authors

Avatar
Top Co-Authors

Avatar

Gregory Moloney

University of British Columbia

View shared research outputs
Researchain Logo
Decentralizing Knowledge