Martin Mowitz

Follow-up of the monitored levels of preservative sensitivity in Europe. Overview of the years 2001-2008

Cecilia Svedman1, Klaus E. Andersen2, F. M. Brandao3, Derk P. Bruynzeel4, Thomas L. Diepgen5, Peter J. Frosch6, Thomas Rustemeyer4, Ana Gimenez-Arnau7, Margarida Goncalo8, An Goossens9, Jeanne Duus Johansen10, Arto Lahti11, Torkil Menne10, Stefania Seidenari12, Antonella Tosti13, Jan E. Wahlberg14, Ian R. White15, John D. Wilkinson15, Martin Mowitz1 and Magnus Bruze1 1Department of Occupational and Environmental Dermatology, SUS, University of Lund, Malmo 205 02, Sweden, 2Department of Dermatology and Allergy Centre, Odense University Hospital, Odense 5000, Denmark, 3Department of Dermatology, Hospital Garcia de Orta, Almada 2805-267, Portugal, 4Department of Dermatology, Free University Hospital, Amsterdam NL-1081 HV, The Netherlands, 5Department of Social Medicine, Centre of Dermato-Epidemiology, Occupational and Environmental Dermatology, University Hospital Heidelberg, Heidelberg 69115, Germany, 6Department of Dermatology, University of Witten/Herdecke, Dortmund 44137, Germany, 7Department of Dermatology, Hospital del Mar, Universitat Automa de Barcelona, Barcelona 08003, Spain, 8Faculty of Medicine, Department of Dermatology, University Hospital, Coimbra P3000-175, Portugal, 9Contact Allergy Unit, Department of Dermatology, U.Z.K.U., Leuven 3000, Belgium, 10Department of Dermato-Allergology, National Research Centre, Gentofte Hospital, University of Copenhagen, Hellerup 2900, Denmark, 11Department of Dermatology, University of Oulu, Oulu FI-90014, Finland, 12Department of Dermatology, University of Modena, Modena 41100, Italy, 13Department of Dermatology, University of Bologna, Bologna I-40138, Italy, 14Norrbacka, Stockholm 171 76, Sweden, and 15Department of Cutaneous Allergy, St John’s Institute of Dermatology, London SEI 7EH, UK

'Calibration' of our patch test reading technique is necessary.

Background. Patch testing has been used for more than 100 years as the best means to diagnose contact allergy. The increased use of the technique makes standardization of the methodology most important. Progress in the standardization of the patch test technique has been made through guidelines.

Allergic contact dermatitis caused by isobornyl acrylate in Freestyle® Libre, a newly introduced glucose sensor

Glucose sensors, such as FreeStyle® Libre, are innovative medical devices developed for diabetes patients as a replacement for classic glucose meters, ensuring continuous glucose monitoring without the disadvantage of regular skin finger pricks.

Stability of fragrance patch test preparations applied in test chambers

Summary Background  Petrolatum patch test preparations are for practical reasons often applied in test chambers in advance, several hours or even days before the patient is tested. As many fragrance compounds are volatile it may be suspected that petrolatum preparations applied in test chambers are not stable over time.

Allergic contact dermatitis caused by 2-ethyl cyanoacrylate contained in glucose sensor sets in two diabetic adults.

Allergic contact dermatitis caused by 2-ethyl cyanoacrylate contained in glucose sensor sets in two diabetic adults Caroline Peeters1,† , Anne Herman1,† , An Goossens2 , Magnus Bruze3 , Martin Mowitz3 and Marie Baeck1 1Department of Dermatology, Cliniques Universitaires Saint-Luc & Pôle Pneumologie, ORL et Dermatologie Institut de Recherche Expérimentale et Clinique (IREC), Université Catholique de Louvain, 1200 Brussels, Belgium, 2Department of Dermatology, University Hospital, Katholieke Universiteit Leuven, 3000 Leuven, Belgium and 3Department of Occupational and Environmental Dermatology, Lund University, Skane University Hospital, 205 02, Malmö, Sweden

Simultaneous patch testing with fragrance mix I, fragrance mix II and their ingredients in southern Sweden between 2009 and 2015

Fragrance mix I (FM I) and fragrance mix II (FM II) are included in the European baseline series as screening substances for fragrance contact allergy.

Chromate and amine contact allergies in workers manufacturing precast concrete elements

Five workers from a plant manufacturing concrete wall panels and beams were referred to our department because of suspected occupational dermatitis. When patch tested, 3 workers reacted to potassium dichromate. Four workers reacted to ethylenediamine dihydrochloride, without any obvious exposure. Owing to the high proportion of workers with recent‐onset skin disease, an investigation of all workers at the plant was initiated.

Fragrance patch tests prepared in advance may give false-negative reactions.

Several of the ingredients in fragrance mix I (FM I) have been shown to evaporate from petrolatum preparations applied in test chambers to an extent that can be suspected to affect the patch test result.

Usage Tests of Oak Moss Absolutes Containing High and Low Levels of Atranol and Chloroatranol.

Atranol and chloroatranol are strong contact allergens in oak moss absolute, a lichen extract used in perfumery. Fifteen subjects with contact allergy to oak moss absolute underwent a repeated open application test (ROAT) using solutions of an untreated oak moss absolute (sample A) and an oak moss absolute with reduced content of atranol and chloroatranol (sample B). All subjects were in addition patch-tested with serial dilutions of samples A and B. Statistically significantly more subjects reacted to sample A than to sample B in the patch tests. No corresponding difference was observed in the ROAT, though there was a significant difference in the time required to elicit a positive reaction. Still, the ROAT indicates that the use of a cosmetic product containing oak moss absolute with reduced levels of atranol and chloroatranol is capable of eliciting an allergic reaction in previously sensitised individuals.

Allergic contact dermatitis caused by isobornyl acrylate in OmniPod, an innovative tubeless insulin pump

The frequency of allergic contact dermatitis caused by (meth)acrylates is increasing worldwide, and isobornyl acrylate (IBOA) has been identified as a culprit sensitizer in FreeStyle Libre, a medical device used by diabetic patients.