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Martin S. Mutter

Janssen Pharmaceutica

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Publication

Featured researches published by Martin S. Mutter.

Tetrahedron Letters | 1988

Highly stereocontrolled proton transfer in an enammonium-iminium rearrangement. Mechanism of the stereoselective deoxygenation of 6-aryl-6-hydroxy-1,2,3,5,6,10b-hexahydropyrrolo[2.1-a]isoquinolines with borane-thf in trifluoroacetic acid.

Bruce E. Maryanoff; David F. McComsey; Martin S. Mutter; Kirk L. Sorgi; Cynthia A. Maryanuff

Abstract Either diastereomer of 2 or 10 is deoxygenated with BH 3 -THF/CF 3 CO 2 H to give mainly the trans product, 3b or 11b . The process involves a key enammonium-iminium rearrangement in which there is almost exclusive proton delivery from a single face.

Journal of the American Chemical Society | 1986

Stereochemistry and mechanism of the Wittig reaction. Diasteromeric reaction intermediates and analysis of the reaction course

Bruce E. Maryanoff; Allen B. Reitz; Martin S. Mutter; Robert R. Whittle; R. A. Olofson

Journal of Organic Chemistry | 1986

Dramatic concentration dependence of stereochemistry in the Wittig reaction. Examination of the lithium salt effect

Allen B. Reitz; Samuel O. Nortey; Alfonzo D. Jordan; Martin S. Mutter; Bruce E. Maryanoff

Journal of the American Chemical Society | 1984

Observation of cis and trans oxaphosphetanes in the Wittig reaction by high-field phosphorus-31 NMR spectroscopy

Allen B. Reitz; Martin S. Mutter; Bruce E. Maryanoff

Journal of Organic Chemistry | 1986

Determination of enantiomeric purity of tertiary amines by 1H NMR of α-methoxy-α-(trifluoromethyl)phenylacetic acid complexes

Frank J. Villani; Michael J. Costanzo; Ruth R. Inners; Martin S. Mutter; David E. McClure

Journal of Organic Chemistry | 1986

Determination of enantiomeric purity of tertiary amines by proton NMR of .alpha.-methoxy-.alpha.-(trifluoromethyl)phenylacetic acid complexes

Frank J. Villani; Michael J. Costanzo; Ruth R. Inners; Martin S. Mutter; David E. McClure

Journal of the American Chemical Society | 1985

Detailed rate studies on the Wittig reaction of nonstabilized phosphorus ylides via phosphorus-31, proton, carbon-13 NMR spectroscopy. Insight into kinetic vs. thermodynamic control of stereochemistry

Bruce E. Maryanoff; Allen B. Reitz; Martin S. Mutter; Ruth R. Inners; Harold R. Almond

Journal of the American Chemical Society | 1989

Stereochemical studies on protonated bridgehead amines. ^1H NMR determination of cis and trans B-C ring-fused structures for salts of hexahydropyrrolo [2,1-a] isoquinolines and related C ring homologs. Capture of unstable ring-fused structures in the solid state

Bruce E. Maryanoff; David F. McComsey; Ruth R. Inners; Martin S. Mutter; Gary Wooden; Stephen L. Mayo; R. A. Olofson

Journal of Organic Chemistry | 1986

Dramatic reversal of diastereoselectivity in an N-acyliminium ion cyclization leading to hexahydropyrrolo[2,1-a]isoquinolines. A case of competing steric interactions

Bruce E. Maryanoff; David F. McComsey; Harold R. Almond; Martin S. Mutter; Guy W. Bemis; Robert R. Whittle; R. A. Olofson

Journal of the American Chemical Society | 1989

Stereochemical studies on protonated bridgehead amines. Proton NMR determination of cis and trans B-C ring-fused structures for salts of hexahydropyrrolo[2,1-a]isoquinolines and related C ring homologs. Capture of unstable ring-fused structures in the solid state [Erratum to document cited in CA110(17):153489F]

Bruce E. Maryanoff; David F. McComsey; Ruth R. Inners; Martin S. Mutter; Gary Wooden; Stephen L. Mayo; R. A. Olofson

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David F. McComsey

Janssen Pharmaceutica

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R. A. Olofson

Pennsylvania State University

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Ruth R. Inners

University of South Carolina

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Allen B. Reitz

Fox Chase Cancer Center

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Bruce E. Maryanoff

Janssen Pharmaceutica

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Gary Wooden

Pennsylvania State University

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Robert R. Whittle

Pennsylvania State University

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Michael J. Costanzo

Janssen Pharmaceutica

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David E. McClure

Merck

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Frank J. Villani

Schering-Plough

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