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Featured researches published by Martina Duft.


Ecotoxicology | 2001

Effects of Endocrine Disruptors on Prosobranch Snails (Mollusca: Gastropoda) in the Laboratory. Part III: Cyproterone Acetate and Vinclozolin as Antiandrogens

Michaela Tillmann; Ulrike Schulte-Oehlmann; Martina Duft; Bernd Markert; Jörg Oehlmann

The effects of suspected endocrine disrupting chemicals on freshwater and marine prosobranch species were analysed in laboratory experiments. In this last of three publications, the responses of the fresh water snail Marisa cornuarietis and of two marine prosobranchs (Nucella lapillus, Nassarius (Hinia) reticulatus) to the antiandrogenic model compounds cyproterone acetate (CPA) and vinclozolin (VZ) are presented. The snails were exposed to nominal CPA concentrations of 1.25 mg/L alone and simultaneously to a potent synthetic estrogen (ethinylestradiol), androgen (methyltestosterone) or an indirectly acting xeno-androgen (tributyltin) in experiments with adult specimens and in a life cycle test for 12 months. Marisa and Nucella were furthermore exposed to nominal concentrations of 0.03–1.0 µg VZ/L for up to 5 months. The antiandrogens induced a number of biological responses in all three species. The length of the penis and of accessory male sex organs (e.g., penis sheath, prostate) were significantly reduced. For Marisa, this effect occurred only in sexually immature specimens and was reversible as the males attained puberty. Typical androgen-mediated responses (imposex development, delayed spermatogenesis, tubulus necrosis of the testis with orchitis and Leydig cell hyperplasia) were partially or totally suppressed by a simultaneous administration of CPA. In the two marine species even adult, sexually mature males responded to antiandrogens with a reduction of the male sex organs and an advancement of the sexual repose phase. The results for CPA and VZ are compared with the effects of an exposure to xeno-estrogens (bisphenol A, octylphenol) and xeno-androgens (triphenyltin, tributyltin) in the same species. Each group of endocrine disruptors induces a characteristic set of toxicological effects in prosobranch snails which can be used as endpoints in an organismic invertebrate test for the identification of endocrine mimetic test compounds. Estrogens cause primarily an induction of superfemales resulting in an increased female mortality by the enhancement of spawning mass and egg production. The main effects of androgens are a virilization of females by imposex development and a marked decrease of the fecundity. Compared with estrogens and androgens, the antiandrogen responses seem to be less drastic and might have–in contrast to the two other disruptor classes–no biologically significant effects at the population level.


Umweltwissenschaften Und Schadstoff-forschung | 2002

Entwicklung eines Sedimentbiotests mit der ZwergdeckelschneckePotamopyrgus antipodarum (Gastropoda: Prosobranchia)

Martina Duft; Michaela Tillmann; Ulrike Schulte-Oehlmann; Bernd Markert; Jörg Oehlmann

ZusammenfassungDerzeit bestehen nur wenige etablierte organismische Testverfahren zur Erfassung von reproduktionstoxischen Effekten, die eine Exposition gegenüber Gesamtsedimenten berücksichtigen. Ein hierfür gut geeigneter Testorganismus ist die parthenogenetische ZwergdeckeischneckePotamopyrgus antipodarum. Sie gehört zu den ovoviviparen (lebendgebärenden) Prosobranchiern und lebt in den obersten Schichten von Süß- und Brackwassersedimenten. Als empfindlicher Parameter zur Indikation reproduktionstoxisch wirkender Sedimentkomponenten erwies sich die Anzahl der (neugebildeten) Embryonen im Brutraum — dieser Endpunkt vermag zudem auf eventuell vorhandene östrogene Wirkstoffe im Sediment hinzuweisen. Mit Hilfe dieses 28 Tage umfassenden Biotests wurden in Laboruntersuchungen die Wirkungen verschiedener Umweltchemikalien, wie z.B. Triphenylzinn und Bisphenol A, aufP. antipodarum in umweltrelevanten Konzentrationsreihen getestet. Darüber hinaus wurde die Eignung des Biotests für die Ermittlung und Untersuchung der Wirkung komplexer Kontaminanten anhand von verschiedenen realen Flussedimenten unterschiedlichen Belastungsgrades — aus Neiße und Oder — erprobt.AbstractCurrently, only few organismic biotest systems are available for the assessment of effects on reproduction, which consider an exposure toward whole sediments. A well-suited test organism is the parthenogenetic mudsnailPotamopyrgus antipodarum. This ovoviviparous prosobranch snail lives in the upper layers of freshwater and brackish sediments. The number of (unshelled) embryos turned out to be a very sensitive parameter for the indication of sediment components affecting reproduction. Additionally, this endpoint allows to signal possible estrogenic sediment compounds.With this 28-day bioassay, laboratory tests on the effects of various chemicals onP. antipodarum were performed, e.g. triphenyltin and bisphenol A, in relevant environmental concentration ranges. Furthermore, the suitability of our test system for the investigation of complex and multiple level ranged contaminations was examined by means of various natural sediments from the Neiße and Odra rivers.


Aquatic Toxicology | 2003

Stimulated embryo production as a parameter of estrogenic exposure via sediments in the freshwater mudsnail Potamopyrgus antipodarum

Martina Duft; Ulrike Schulte-Oehlmann; Lennart Weltje; Michaela Tillmann; Jörg Oehlmann


Ecotoxicology | 2007

Endocrine disruption in prosobranch molluscs: evidence and ecological relevance

Jörg Oehlmann; Patrizia Di Benedetto; Michaela Tillmann; Martina Duft; Matthias Oetken; Ulrike Schulte-Oehlmann


Ecotoxicology | 2007

Prosobranch snails as test organisms for the assessment of endocrine active chemicals--an overview and a guideline proposal for a reproduction test with the freshwater mudsnail Potamopyrgus antipodarum.

Martina Duft; Claudia Schmitt; Jean Bachmann; Cornelius Brandelik; Ulrike Schulte-Oehlmann; Jörg Oehlmann


Environmental Toxicology and Chemistry | 2003

Toxicity of triphenyltin and tributyltin to the freshwater mudsnail Potamopyrgus antipodarum in a new sediment biotest.

Martina Duft; Ulrike Schulte-Oehlmann; Michaela Tillmann; Bernd Markert; Jörg Oehlmann


Umweltwissenschaften Und Schadstoff-forschung | 2001

Östrogenartige wirkungen von bisphenol a auf vorderkiemenschnecken (Mollusca: Gastropoda: Prosobranchia)

Ulrike Schulte-Oehlmann; Michaela Tillmann; Daire Casey; Martina Duft; Bernd Markert; Jörg Oehlmann


Coastal marine science | 2005

Biological impact of organotin compounds on mollusks in marine and freshwater ecosystems

Martina Duft; Ulrike Schulte-Oehlmann; Michaela Tillmann; Lennart Weltje; Jörg Oehlmann


Umweltwissenschaften Und Schadstoff-forschung | 2001

Xeno-estrogenic effects of bisphenol A in prosobranchs (mollusca: Gastropoda: Prosobranchia)

Ulrike Schulte-Oehlmann; Michaela Tillmann; Daire Casey; Martina Duft; Bernd Markert; Jörg Oehlmann


Umweltwissenschaften Und Schadstoff-forschung | 2004

Ökotoxikologische Sedimentbewertung großer Fließgewässer mit Nematoden und Gastropoden: Vom Biotest zum Freiland : 2003 Promotion an der J.W. Goethe-Universität Frankfurt am Main bei Prof. Dr. Jörg Oehimann (Dissertationen)

Martina Duft

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Jörg Oehlmann

Goethe University Frankfurt

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Michaela Tillmann

Dresden University of Technology

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Bernd Markert

University of Osnabrück

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Lennart Weltje

Delft University of Technology

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Claudia Schmitt

Goethe University Frankfurt

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Jörg Oehlmann

Goethe University Frankfurt

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Matthias Oetken

Goethe University Frankfurt

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