Martina Parizkova

EGOCENTRIC SPATIAL NAVIGATION IMPAIRMENT IS MORE PRONOUNCED IN AMYLOID POSITIVE MCI PATIENTS: PILOT DATA FROM THE CZECH BRAIN AGEING STUDY

Visual hallucinations 86% 28% 22.9 <0.001 REM sleep behaviour Disorder 53% 33% 2.49 0.12 Cognitive fluctuation 75% 11% 22.8 <0.001 One or more carer stress events 59% 29% 3.00 0.22 O5-03-06 EGOCENTRIC SPATIAL NAVIGATION IMPAIRMENT IS MORE PRONOUNCED IN AMYLOID POSITIVE MCI PATIENTS: PILOT DATA FROM THE CZECH BRAIN AGEING STUDY Jiri Cerman, Jan Lacz o, Martin Vyhnalek, Martina Parizkova, Otakar Belohlavek, Jana Malinovska, Ond rej Lerch, Katerina Sheardova, Jakub Hort, Department of Neurology, 2nd Faculty of Medicine, Charles University and Motol University Hospital, Prague, Czech Republic; International Clinical Research Center, St. Anne’s University Hospital, Brno, Czech Republic; Charles University, 2nd Faculty of Medicine and Motol University Hospital, Prague, Czech Republic; Department of Neurology, Charles University, 2nd Faculty of Medicine and Motol University Hospital, Prague, Czech Republic; Memory Clinic, Department of Neurology, 2nd Faculty of Medicine, Charles University and Motol University Hospital, Prague, Czech Republic; Na Homolce Hospital, Department of Nuclear Medicine and PET Center, Prague, Czech Republic; 2nd Faculty of Medicine, Charles University and Motol University Hospital, Department of Neurology, Prague, Czech Republic; Charles University, 2nd Faculty of Medicine and Motol University Hospital, Prague, Prague, Czech Republic; International Clinical Research Center, St. Anne’s University Hospital Brno, Brno, Czech Republic. Contact e-mail: cermanster@gmail.com

EFFECT OF ALZHEIMER’S DISEASE ON SPATIAL PATTERN SEPARATION

investigated the use of the NIH-Toolbox-Cognition computerized neuropsychological battery in the identification of amnestic MCI (aMCI) compared to healthy older adults in a sample of AfricanAmerican and Caucasian seniors. Methods: Ninety-three African American and 75white older adults were recruited from the University of Michigan Alzheimer’s Disease Center (MADC) and the Wayne State University Institute of Gerontology’s Healthy Black Elders Center (WSU-HBEC). All were enrolled in the longitudinal cohort of theMADC and underwent complete NACCUniformData Set (UDS) assessment, being diagnosed via consensus conference as aMCI (n 1⁄4 47, 72.54 6 7.4 years) or cognitively healthy older adults (n 1⁄4 121, 70.59 6 7.4 years). Computerized tests were not used for consensus. All Toolbox subscales were evaluated through Diagnosis by Race ANOVAs, adjusted for age and education, using each of the Toolbox available scores (unadjusted, age-adjusted, percentile, fully-adjusted). After evaluation of those results, ROC Area under curve (AUC) analyses were conducted to determine discriminatory ability of each Toolbox composite and subtest measure. Results:ANOVAs revealed a number of significant main effects and interactions across both Fluid and Crystalized Toolbox measures when using all but the fully-adjusted scores, so those scores were used for AUC analyses. Total (0.846) and Fluid Composites (0.815) had the highest or “good classification” AUC values, with five other subtests (Pattern Comparison, Picture Sequence Memory, Crystalized Composite, Picture Vocabulary, Dimensional Card Sort) between 0.75-0.720 (“fair”). The fullyadjusted subtests with significant race main effects or interactions (Oral Reading, List Sort, Flanker) had AUC values below 0.70. Conclusions: Fully-adjusted Toolbox-Cognitive scores appear least sensitive to race effects. In terms of discriminating aMCI cases from controls, the Total and Fluid Composites appeared strongest.

EGOCENTRIC NAVIGATION IMPAIRMENT IS ASSOCIATED WITH FALL RISK IN OLDER ADULTS WITH NEURODEGENERATIVE DEMENTIA

P3-261 EGOCENTRIC NAVIGATION IMPAIRMENT IS ASSOCIATEDWITH FALL RISK IN OLDER ADULTS WITH NEURODEGENERATIVE DEMENTIA Jiri Cerman, Jan Lacz o, Martina Parizkova, Adela Fendrych Mazancova, Ondrej Cakrt, Jakob Hort, Memory Clinic, Department of Neurology, 2nd Faculty of Medicine, Charles University in Prague and Motol University Hospital, Prague, Czech Republic; Memory Clinic, Department of Neurology, 2nd Faculty of Medicine, Charles University and Motol University Hospital, Prague, Czech Republic; Diamant Neuropsychology Laboratory, Department of Neurology and Centre of Clinical Neuroscience, 1st Faculty of Medicine and General University Hospital in Prague, Charles University, Prague, Czech Republic; 2nd Faculty of Medicine, Charles University and Motol University Hospital, Prague, Czech Republic. Contact e-mail: arnoldator@ email.cz

THE EFFECT OF EARLY-STAGE ALZHEIMER’S DISEASE ON SPATIAL NAVIGATION STRATEGIES: A PILOT STUDY

pentagon drawing: t (53) 1⁄4 2.016, p < .05; for the four ADAS-Cog drawings: t (53) 1⁄4 2.89, p < .01. Subjects were able to copy designs with more accuracy on paper as compared to the tablet. Conclusions: Completing praxis tasks on a tablet computer resulted in significantly lower scores as compared to paper and pencil techniques. These methodologies do not seem to be equivalent. The subjects in this study were young, healthy normals and results with an older, demented population with less experience using tablet technology would presume to be increasingly detrimental. More research is needed to fully understand the impact of tablet technology on traditional assessment of cognition in Alzheimer’s disease.

DISTINCT SPATIAL NAVIGATION IMPAIRMENT ACROSS NEURODEGENERATIVE DEMENTIAS AND ITS NEUROANATOMICAL UNDERPINNINGS

decline is increased substantially by the presence of at least one copy of the APOE ε4 allele. Despite advances in Ab biomarkers, age remains the greatest risk factor for dementia, particularly Alzheimer’s disease (AD). As APOE ε4 increases risk for Ab+ and older adults are also more likely to be Ab+, it is important to understand the extent to which age influences the effects of ε4 on Ab+ related memory decline. This study aimed to determine the extent towhich theAPOE ε4 allele influenced Ab related cognitive change in adults aged between 60-74 and 75-90 years old. Methods:Nondemented adults (n1⁄4485) enrolled in the AIBL study underwent Ab neuroimaging and ε4 genotyping. Episodic Memory was assessed at baseline, 18-, 36-, 54and 72-month follow-ups. Participants were classified as Abor Ab+ using PET neuroimaging and into two age groups (<75 and 75) according to their age at baseline. Data were analysed using linear mixed model analyses. Results:In adults aged<75, when compared to the Abgroup, there was a significant rate of memory decline only in Ab+ ε4 carriers (d1⁄41.25). In adults aged 75, when compared to the Abgroup, both Ab+ ε4 carriers (d1⁄41.23) and non-carriers (d1⁄40.35) showed significant rates of memory; however, the memory decline in Ab+ ε4 carriers was substantially greater when compared to noncarriers (d1⁄40.82). This faster rate of memory decline in adults aged 75 was reflected in a 43% of Ab+ ε4 carriers meeting clinical criteria for dementia at the 72-month assessment, in contrast to just 24% of Ab+ ε4 non-carriers and 10% of Abparticipants. Conclusions:Previous studies investigating the relationship between ε4 andAb+have not accounted for potential non-linear effects of age on memory decline. The rate of Ab+ related memory decline was greatest in adults aged 75, particularly in those who were also APOE ε4 carriers. This suggests that the combined effects of Ab+ and ε4 on risk for dementia increases substantially in older adults.

THE EFFECT OF APOE E4 ON EPISODIC MEMORY IN PATIENTS WITH AMNESTIC MILD COGNITIVE IMPAIRMENT

P1-182 THEEFFECTOFAPOEE4ONEPISODICMEMORY IN PATIENTSWITHAMNESTICMILDCOGNITIVE IMPAIRMENT Ivana Mokrisova, Jan Laczo, Martina Parizkova, Kamil Vlcek, Martin Vyhnalek, Katerina Sheardova, Vojtech Kaplan, Vaclav Matoska, Ross Andel, Jakob Hort, Memory Clinic, Department of Neurology, 2nd Faculty of Medicine, Charles University in Prague and Motol University Hospital, Prague, Czech Republic; 2 International Clinical Research Center, St. Anne’s University Hospital Brno, Brno, Czech Republic; Department of Neurophysiology of Memory, Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic; 4 Department of Clinical Biochemistry, Hematology and Immunology, Homolka Hospital, Prague, Czech Republic; School of Aging Studies, University of South Florida, Tampa, FL, USA. Contact e-mail: mokrisova.ivana@gmail.com

Scopolamine disrupts allocentric spatial navigation in humans: The study in a real-space analogue of the morris water maze

included only Moderate/Severe CKD but added duration (years) of CKD. Results: 393 participants [moderate CKD N1⁄4308, mean eGFR1⁄430.6 (10.0); mild CKD N1⁄486 (eGFR1⁄4 49.7 (4.2)] were recruited. Demographics are described in Table 1; moderate/severe vs. mild CKD participants were slightly less educated and had higher systolic BP. The linear association between eGFR and severity of CI (none, mild, moderate, severe) was moderate but significant (rho1⁄4 -.15 P1⁄4 .001). In Model 1 (mod/sev and mild CKD), Black race (AOR 3.5 (1.8, 6.5: p 1⁄4 <.001) and phosphorous level (AOR 1.5 (1.02, 2.1: p 1⁄4 .04) were significantly associated with mod/sev CI. In Model 2 (mod/sev CKD only), age (1.4 (1.07, 2.0: p 1⁄4 .02), male gender (1.9 (1.02, 3.5: p 1⁄4 .04) Black race (5.7(2.5, 12.7: p<.001), phos (1.6 (1.06, 2.5:p1⁄4 .03), and duration of CKD (1.03/year (1.007, 1.06: p 1⁄4 .01) were significant. Conclusions: Age, Black race, male gender, elevated phosphorous and CKD duration were significantly associated with mod/severe CI in Stages 3b-5 CKD. Phosphorous level as a modifiable risk factor, and a threshold effect of CKD duration on risk of CI need further exploration in our future longitudinal analyses.

Tomm40 ‘523’ polymorphisms may influence cognitive functions in patients with amnestic mild cognitive impairment

P2-091 TOMM40 ‘523’ POLYMORPHISMS MAY INFLUENCE COGNITIVE FUNCTIONS IN PATIENTS WITH AMNESTIC MILD COGNITIVE IMPAIRMENT Ivana Mokrisova, Jan Lacz o, Martina Parizkova, Kamil Vl cek, Martin Vyhnalek, Vojt ech Kaplan, V aclav Ma to ska, Jakub Hort, International Clinical Research Center, St. Anne’s University Hospital Brno, Brno, Czech Republic; Memory Clinic, Department of Neurology, 2nd Faculty of Medicine, Charles University in Prague and Motol University Hospital, Prague, Czech Republic; Department of Neurophysiology of Memory, Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic; Department of Clinical Biochemistry, Hematology and Immunology, Homolka Hospital, Prague, Czech Republic. Contact e-mail: mokrisova.ivana@gmail.com

DIFFERENCES IN SPATIAL AND TEMPORAL ORDER MEMORY IN VARIOUS NEURODEGENERATIVE DEMENTIAS

memory (MOD-MEM) included 43% of patients. On visual inspection these patients had more severe MTA and were more often APOE e4 positive. Memory-spared clusters mild-executive (MILD-EXE), mild-visuoperception-language (MILD-VILA) and moderate-visuospatial (MOD-VISP) included 30% of patients. Using MILD-MEM as reference cluster, younger age was associated with higher likelihood for membership of MOD-VISP (Odds Ratio [OR] 6.21, 95% confidence interval [CI] 3.56-10.83) and MILD-EXE (OR 2.06, CI 1.32-3.23). Membership of MOD-VISP was more likely when APOE e4 was absent (OR 1.82, CI 1.04-3.20) and PA and GCAwere more severe (resp. OR 2.17, CI 1.15-4.10 and OR 2.64, CI 1.44-4.84). On visual inspection, MTA was less severe in memory-spared clusters than in other clusters. Finally, mild-diffuse (MILD-DIFF), moderate-language (MOD-LAN) and severe-diffuse (SEV-DIFF) were characterized by a memory-indifferent profile and included 28% of patients. Using MILD-MEM as reference, membership of SEV-DIFF was more likely when patients were younger (OR 2.77, CI 1.65-4.63), had longer duration of complaints (OR 2.18, CI 1.04-4.57) and had more severe PA and GCA (resp. OR 2.10, CI 1.07-3.76 and OR 2.28, CI 1.29-4.03). Conclusions: We demonstrated that LCA is an eligible method to identify cognitive subtypes in AD dementia using an extensive neuropsychological test battery. The cluster characteristics we found corresponded with earlier findings regarding the association between neurobiological characteristics and cognition.