Martina Schaefer
Bayer Schering Pharma AG
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Publication
Featured researches published by Martina Schaefer.
BMC Pharmacology | 2011
Focco van den Akker; Faye Martin; Vijay Kumar; Xiaolei Ma; Johannes-Peter Stasch; Martina Schaefer; Padmamalini Baskaran; Annie Beuve; Pete W. Dunten
Background The soluble guanylyl cyclase (sGC) is a key enzyme involved in the production of the second messenger cGMP. Due its cardiovascular relevance, sGC has been the target of numerous drug discovery efforts leading to the development of many different activators and stimulators with pharmaceutical potential. One of such compounds is the sGC activator Cinaciguat (BAY 58-2667) which is in clinical trials for acute decompensated heart failure. Results We present here our latest structure-function studies related to sGC activation by different sGC activators. The activator complex structures reveal an intriguing mode of heme mimicry by these compounds. The observed activation conformational changes center around the aF helix that contains the H105 residue normally held in place by the heme moiety in the absence of the activators. Conclusion
Archive | 2003
Ulrich Luecking; Gerhard Siemeister; Martina Schaefer; Hans Briem
Archive | 2006
Ulrich Luecking; Georg Kettschau; Hans Briem; Wolfgang Schwede; Martina Schaefer; Karl-Heinz Thierauch; Manfred Husemann
Archive | 2005
Georg Kettschau; Hans Briem; Ingo Hartung; Ulrich Luecking; Martina Schaefer; Karl-Heinz Thierauch; Wolfgang Schwede; Manfred Husemann
Archive | 2006
Hans Briem; Karl-Heinz Thierauch; Georg Kettschau; Martina Schaefer; Wolfgang Schwede; Manfred Husemann; Laak Antonius Ter; Hermann Kuenzer; Stuart James Ince
Archive | 2005
Georg Kettschau; Hans Briem; Andreas Huth; Ulrich Luecking; Martina Schaefer; Karl-Heinz Thierauch; Wolfgang Schwede; Manfred Husemann
Archive | 2008
Duy Nguyen; Arne Von Bonin; Michael Haerter; Hartmut Schirok; Anne Mengel; Martina Schaefer; Oliver Von Ahsen
Tetrahedron Letters | 2007
Ben Bader; Arne Von Bonin; Bernd Buchmann; Stephan Gruendemann; Judith Guenther; Martina Schaefer; Tilman Spellig; Thomas M. Zollner; Ludwig Zorn
Archive | 2006
Wolfgang Schwede; Hans Briem; Hermann Kuenzer; Manfred Husemann; Georg Kettschau; Martina Schaefer; Antonius Ter Laak; Karl-Heinz Thierauch; Stuart James Ince
Archive | 2007
Ingo Hartung; Georg Kettschau; Hans Briem; Ulrich Luecking; Martina Schaefer; Philip Lienau; Ulf Boemer; Karl-Heinz Thierauch
