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Featured researches published by Marvin C. Hallberg.


Metabolism-clinical and Experimental | 1969

Serum gonadotropin and testosterone levels in uremic males undergoing intermittent dialysis

Amelia Guevara; D. Vidt; Marvin C. Hallberg; Elinor M. Zorn; Carol Pohlman; Ralph G. Wieland

Abstract Twenty-six adult males with uremia due to chronic renal disease were studied to determine the circulating levels of gonadotropins. In some of these patients serum testosterone levels were also measured. Patients receiving intermittent hemodialysis had higher levels of luteinizing hormone (LH) than normals, uremic patients not receiving dialysis and patients on peritoneal dialysis. Serum testosterone levels tended to be low in uremic patients. No significant alterations in follicle-stimulating hormone (FSH) were observed in the groups studied. Uremia seems to effect Leydig cell function without producing an associated rise in gonadotropins with the exception of an increase in LH in patients on intermittent hemodialysis.


Steroids | 1968

A sensitive testosterone assay by protein-binding

Marvin C. Hallberg; Elinor M. Zorn; Ralph G. Wieland

Abstract A sensitive assay utilizing protein-binding has been developed for the measurement of testosterone in biological fluids. The assay utilizes pregnancy serum diluted to 0.25% to which testosterone-3H has been added. Only 2 ml of peripheral serum are required to satisfactorily measure normal female levels.


Fertility and Sterility | 1973

Pituitary-gonadal rhythms in the eugonadal adult male.

Ralph G. Wieland; Marvin C. Hallberg; Keith R. Koepke; Elinor M. Zorn

The regulation of the pituitary-testicular axis was studied in 4 healthy male volunteers (mean age 33 married 2-4 children) at Saint Lukes Hospital in Cleveland. During a 4-hour period commencing between 8-10 AM peripheral samples were obtained every 15 minutes for the determination of follicle-stimulating hormone lutenizing hormone and testosterone. The secretions of the gonadotropins and testosterone were episodic and unrelated within each individual. The number of peaks varied interindividually and the various hormones had different numbers of peaks intraindividually. No support was gained for the concept that fluctuations of basal secretion in normal males are caused by negative feedback control.


American Journal of Obstetrics and Gynecology | 1976

Hormonal evaluation of premature menarche produced by a follicular cyst

Ralph G. Wieland; Rafael Bendezu; Marvin C. Hallberg; Peter Tang; Kenneth Webster

blood collected from their respective mothers at the time of delivery. Those preparations were always white. We studied these cells carefully and found a significant contamination of the lymphocytes by nucleated red ceils. When blood from these children was again studied six to eight weeks later with the same methods, we found that the T and B cells had apparently returned to normal. Smears had been made for differential analysis from the cord blood of those erythroblastotic children. We found a range of 89 to 120 nucleated red cells per 100 white cells in those infants. By six weeks of age, the reticulocyte count in these inf-ants had returned to normal levels of 4 per cent or less. coincident with the elevation to apparently normal levels of the T and B cells. It was not until the fifth erythroblastotic infant that we finally found an effective technique by which we could remove the nucleated red cells from the lymphocyte preparations without negativeIy affecting the lymphocytes. We found that the simple modification of adding 2 ml, of distilled water to the lymphocyte pellet, dispersing the cells for twenty seconds by pipetting, and then immediatelv adding a salt solution of sufficient strength to biing the molarity of the solution to O.l.?hi resulted in lysis of the nucleated red cells only, with retained functional lymphocytes. Cord blood was obtained at the time of delivery of this erythroblastotic infant, and the lymphocytes from the Ficollhypdque gradient interface were separated into two halves. Half of these cells were processed in the usual fashion, and half were water lysed. T and B cell determinations were then accomplished in the standard fashion on both samples. The sampIe that was studied without removal of. nucleated red blood cells was read as being 6 per cent T cells and 4 per cent B cells while t.he other aliquot gave 41 per cent T cells and 15 per cent B cells. All treated mothers who were studied (five) were fomld to have normal adult levels of both T and B cells (54 ? 6 r’s and 15 ? 3 B’s). There was no apparent effect of the promethazine hydrochloride on maternal lymphocyte numbers. 0ur first impression that the low levels of T and B cells found in the erythroblastotic newborn infant might be clue to the promethazine hydrochloride treatment was erroneous. When contaminating nucleated red cells were removed from the lymphocyte preparation, the levels of T and B cells in the patients studied so far appeared to be normal. In a recvnt paper by Rubinstein and associates,’ the authors have taken d situation with two variables. the disease pj-ocess erythrobiastosis and the


Fertility and Sterility | 1976

Impaired Leydig Cell Reserve and Altered Serum Androgen Binding in the Aging Male**Supported in part by a General Research Support grant from the National Institutes of Health.

Marvin C. Hallberg; Ralph G. Wieland; Elinor M. Zorn; Barry H. Furst; Jeffrey M. Wieland

The hormonal profile of the aging male reveals an associated decrease in free testosterone and 5 alpha-dihydrotestosterone (DHT) levels and increased luteinizing hormone levels. Later events consist of a decrease in total testosterone, stable DHT, and increased follicle-stimulating hormone and estradiol levels. Although most available information supports the concept of impaired Leydig cell reserve, our study suggests some degree of hypothalamic-pituitary dysfunction. The signal for increased androgen binding with age is not clear. There is a great deal of individual variation in the time of onset of these events.


Journal of Laboratory and Clinical Medicine | 1979

Effect of dietary weight loss on sex steroid binding, sex steroids, and gonadotropins in obese postmenopausal women

John P K O'dea; Ralph G. Wieland; Marvin C. Hallberg; Luis A. Llerena; Elinor M. Zorn; Saul Genuth


Clinical Chemistry | 1971

Antibodies to Testosterone-3-Bovine Serum Albumin, Applied to Assay of Serum 17β-ol Androgens

Jeffrey C. Chen; Elinor M. Zorn; Marvin C. Hallberg; Ralph G. Wieland


The Journal of Clinical Endocrinology and Metabolism | 1970

Pituitary-Leydig Cell Function in Uremic Males

Jeffrey C. Chen; Donald G. Vidt; Elinor M. Zorn; Marvin C. Hallberg; Ralph G. Wieland


Fertility and Sterility | 1972

Idiopathic Oligospermia: Control Observations and Response to Cisclomiphene

Ralph G. Wieland; Amir H. Ansari; David E. Klein; Narendra S. Doshi; Marvin C. Hallberg; Jeffrey C. Chen


The Journal of Clinical Endocrinology and Metabolism | 1969

Spermatic and Peripheral Venous Levels of Gonadotropin and Testosterone in a Teratoma with Embryonal Cell Carcinoma

Ralph G. Wieland; Amelia Guevara; Marvin C. Hallberg; Elinor M. Zorn; Carol Pohlman

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Ralph G. Wieland

Case Western Reserve University

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Barry H. Furst

Case Western Reserve University

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David E. Klein

Case Western Reserve University

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Jeffrey M. Wieland

Case Western Reserve University

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Narendra S. Doshi

Case Western Reserve University

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