Mary K. Gospodarowicz

Localized Mucosa-Associated Lymphoid Tissue Lymphoma Treated With Radiation Therapy Has Excellent Clinical Outcome

PURPOSE Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) is a distinct lymphoma with unique clinicopathologic features. We report the clinical outcome of stage I and II MALT lymphoma treated with involved field radiation therapy (RT). PATIENTS AND METHODS From 1989 to 2000, 103 patients with stage IE and IIE disease were referred. Their median age was 60 years, with a 2:1 female predominance. Presenting sites were stomach (17 patients), orbital adnexa (31 patients), salivary glands (24 patients), thyroid gland (13 patients), and other sites (18 patients). Ninety-three patients received RT--85 received RT alone, and eight received chemotherapy and RT--with a median dose of 30 Gy. The median follow-up time was 5.1 years. RESULTS A complete response (CR) to RT alone was achieved in 84 of 85 patients. Among CR patients, 14 experienced relapse. Relapse sites were mostly contralateral paired-organ or distant MALT locations and, infrequently, lymph nodes. The crude local control rate with RT was 95.3% (81 of 85 patients). No relapses were observed in patients with stomach or thyroid lymphoma, whereas 14 of 63 patients (22%) experienced relapse in the other sites. The overall 5-year survival rate was 98%, and the disease-free survival rate was 77%. Transformed lymphoma was observed in 14% of patients (two of 14) experiencing relapse. CONCLUSION Moderate-dose RT achieved excellent local control in localized MALT lymphomas and had curative potential for three fourths of the patients. Gastric and thyroid MALT lymphomas had better outcome, whereas distant failures were common for other sites. Despite relapse, the disease often maintained an indolent course.

Solitary plasmacytoma treated with radiotherapy: Impact of tumor size on outcome

PURPOSE Solitary plasmacytoma (SP) is a rare presentation of plasma cell neoplasms. In contrast to multiple myeloma, long-term disease-free survival and cure is possible following local radiotherapy (RT), particularly for soft tissue presentations. In this study, we attempt to identify factors that predict for local failure, progression to multiple myeloma, and disease-free survival (DFS) in patients mainly managed with local RT. METHODS AND MATERIALS We identified 46 patients referred to the Princess Margaret Hospital between 1982 and 1993. The median age was 63 years (range 35-95), with a male:female ratio of 1.9:1. All patients had biopsy-proven SP (osseous: 32, soft tissue: 14). M-protein was abnormal in 19 patients (41%). All patients were treated with local RT (median dose 35 Gy), with 5 patients (11%) also receiving chemotherapy. Maximum tumor size pre-RT ranged from 0 to 18 cm (median 2.5). RESULTS The 8-year overall survival, DFS, and myeloma-free rates were 65%, 44%, and 50%, respectively. The local control rate was 83%. Factors predictive of progression to myeloma (and poorer DFS) included bone presentation and older age. However, these two factors did not influence local control, which was affected by tumor size. All tumors < 5 cm in bulk (34 patients) were controlled by RT. Anatomic location did not predict outcome; however, 3 of the 5 tumors arising in paranasal sinuses did not achieve local control. Lower RT dose (< or =35 Gy) was not associated with a higher risk of local failure. CONCLUSION Solitary plasmacytomas are effectively treated with moderate-dose RT, although osseous tumors have a high rate of recurrence as systemic myeloma. Large tumor bulk locally (> or =5 cm) predicts for local failure. Combined chemotherapy and RT should be investigated in these high-risk patients to increase the local control rate and the cure rate.

Stage I and II MALT lymphoma : results of treatment with radiotherapy

PURPOSE Mucosa-associated lymphoid tissue (MALT) lymphoma is a distinct disease with specific clinical and pathologic features that may affect diverse organs. We analyzed our recent experience with Stage I/II MALT lymphoma presenting in the stomach and other organs to assess the outcome following involved field radiation therapy (RT). PATIENTS AND METHODS Seventy patients with Stage IE (62) and IIE (8) disease were treated between 1989 and 1998. Patients with transformed MALT were excluded. The median age was 62 years (range, 24--83 years), M:F ratio 1:2.2. Presenting sites included stomach, 15; orbital adnexa, 19; salivary glands, 15; thyroid, 8; lung, 5; upper airways, 3 (nasopharynx, 2; larynx, 1); urinary bladder, 3; breast, 1; and rectum, 1. Staging included site-specific imaging, CT abdomen in 66 patients (94%) and bone marrow biopsy in 54 (77%). Sixty-two patients received radiation therapy: 52 received RT alone, 7 received chemotherapy and RT, and 3 received antibiotics followed by RT. Median RT dose was 30 Gy (range, 17.5--35 Gy). Most frequently used RT prescriptions were 25 Gy (26 patients-18 orbit, 6 stomach, and 2 salivary glands), 30 Gy (23 patients), and 35 Gy (8 patients). Five patients had complete surgical excision of lymphoma and no other treatment (stomach 1, salivary 2, lung 2), whereas 2 patients with gastric lymphoma received antibiotics only. One patient refused treatment and was excluded from the analysis of treatment outcome, leaving 69 patients with a median follow-up of 4.2 years (range, 0.3-11.4 years). RESULTS A complete response was achieved in 66/69 patients, and 3 patients had partial response (2 lung, 1 orbit). The 5-year disease-free survival (DFS) was 76%, and the overall survival was 96%. No relapses were observed in patients with stomach and thyroid lymphoma. The 5-year DFS for these patients was 93%, in contrast to 69% for patients presenting in other sites (p = 0.006). Among the 5 patients treated with surgery only, 2 relapsed locally (lung, and minor salivary gland). Among 62 patients who received RT, 8 relapsed (2 salivary, 3 orbit, 1 nasopharynx, 1 larynx, 1 breast). Three patients relapsed in the nonirradiated contralateral paired organ, 4 in distant sites, and 1 in both local and distant sites. The overall local control rate with radiation was 97% (60/62 patients). CONCLUSION Localized MALT lymphomas have excellent prognosis following moderate-dose RT. Gastric and thyroid MALT lymphomas have better early outcome, as compared to the other sites where distant failure is more common. Relapses were observed in nonirradiated paired organs or distant sites. Further follow-up is required to assess the impact of failure on survival.

Non–Risk-Adapted Surveillance in Clinical Stage I Nonseminomatous Germ Cell Tumors: The Princess Margaret Hospital’s Experience

BACKGROUND Since 1981 Princess Margaret Hospital has used initial active surveillance (AS) with delayed treatment at relapse as the preferred management for all patients with clinical stage I nonseminomatous germ cell tumors (NSGCT). OBJECTIVE Our aim was to report our overall AS experience and compare outcomes over different periods using this non-risk-adapted approach. DESIGN, SETTING, AND PARTICIPANTS Three hundred and seventy-one patients with stage I NSGCT were managed by AS from 1981 to 2005. For analysis by time period, patients were divided into two cohorts by diagnosis date: initial cohort, 1981-1992 (n=157), and recent cohort, 1993-2005 (n=214). INTERVENTION Patients were followed at regular intervals, and treatment was only given for relapse. MEASUREMENTS Recurrence rates, time to relapse, risk factors for recurrence, disease-specific survival, and overall survival were determined. RESULTS AND LIMITATIONS With a median follow-up of 6.3 yr, 104 patients (28%) relapsed: 53 of 157 (33.8%) in the initial group and 51 of 214 (23.8%) in the recent group. Median time to relapse was 7 mo. Lymphovascular invasion (p<0.0001) and pure embryonal carcinoma (p=0.02) were independent predictors of recurrence; 125 patients (33.7%) were designated as high risk based on the presence of one or both factors. In the initial cohort, 66 of 157 patients (42.0%) were high risk and 36 of 66 patients (54.5%) relapsed versus 17 of 91 low-risk patients (18.7%) (p<0.0001). In the recent cohort, 59 of 214 patients (27.6%) were high risk and 29 of 59 had a recurrence (49.2%) versus 22 of 155 low-risk patients (14.2%) (p<0.0001). Three patients (0.8%) died from testis cancer. The estimated 5-yr disease-specific survival was 99.3% in the initial group and 98.9% in the recent one. CONCLUSIONS Non-risk-adapted surveillance is an effective, simple strategy for the management of all stage I NSGCT.

Staging and management of localized non-Hodgkin’s lymphomas: variations among experts in radiation oncology

PURPOSE To examine the opinions of radiation oncology experts on the management of lymphomas with respect to staging procedures, treatment plan, radiation target volume, and dose prescription. Our aim was to identify the patterns of practice and areas of controversy that may need to be resolved and be amenable to prospective clinical trials. MATERIALS AND METHODS Radiation oncology experts in lymphoma management were identified from academic centers in the United States, Europe, and Canada. A sample of individuals with a publication record and/or participation in the design and execution of lymphoma clinical trials (n = 33) were mailed a questionnaire of five case scenarios. The experts were asked to specify their approaches to staging investigations, treatment plan, radiation target volume, and dose prescription for each scenario. Radiation fields were indicated by the respondents on a schematic anatomy diagram on the questionnaire. The response rate to the survey was 82% (27/33). RESULTS Staging of lymphomas relied on the use of imaging, because computed tomography of the abdomen and pelvis was recommended in all cases, and computed tomography of the uninvolved thorax was advocated by 70% of respondents. A lymphangiogram and a gallium scan were suggested by, respectively, 26% and 25% of respondents. The overall treatment plan was uniform for the four cases of localized presentations of lymphoma. However, the details of chemotherapy and radiation target volume varied significantly. Variations were observed in recommendations regarding the number of courses of chemotherapy and the extent of radiotherapy. The survey documented significant differences in the recommended radiation therapy (RT) dose (30-50 Gy). The scenario of leptomeningeal relapse in diffuse large B-cell lymphoma documented the most diverse treatment recommendations. These varied from whole-brain radiation alone to systemic and intrathecal chemotherapy, radiation with craniospinal coverage, and high-dose chemotherapy with bone marrow transplantation. CONCLUSIONS This survey demonstrated a high degree of consensus regarding the overall management plan of localized lymphomas among the sampled expert radiation oncologists. However, the recommendations regarding the specifics of chemotherapy and RT remain variable. There is clearly no agreement on the most appropriate RT dose and volume. The large variation in the treatment of leptomeningeal relapse of diffuse large B-cell lymphoma suggests that the optimal treatment in this situation is poorly defined, and the clinical outcome with RT, as well as the rationale for decision making, should be examined in more detail.

Role of radiation therapy in localised non-Hodgkin's lymphomas

Abstract Radiation therapy plays an essential role in the management of localised NHL. Its application varies from monotherapy management of localised follicular and MALT lymphomas with intent to cure, to being an integral part of combined modality therapy for diffuse large-cell lymphoma. In addition, the role of radiation therapy in the management of specific extranodal lymphomas deserves special attention. Regrettably, the emphasis on drug therapy has overshadowed research efforts to optimise the application of radiation therapy in the management of lymphomas. Recent advances in conformal radiation therapy techniques need to be applied to the management of lymphomas to further improve RT toxicity, while offering the patients the benefits of permanent local disease control.

Clinical Situations for the Role of Radiation Therapy in the Treatment of Bladder Cancer

The majority of bladder cancer patients present with superficial disease and are managed with conservative measures using transurethral resection with or without intravesical chemotherapy. Approximately 20–25% present with muscle invasive bladder cancer, that is potentially life threatening and requires radical treatment. Definitive radiation therapy (RT) has been used for muscle invasive bladder cancer since the early 1900s and there is evidence that patients can achieve durable local control and maintain a functional bladder without a compromise in survival. However, the standard North American approach to the management of bladder cancer not suitable for conservative measures is radical cystectomy (1). In the past few decades, radical radiation therapy has been used in patients who either refused or were not suitable for radical cystectomy. Therefore, there is a limited amount of information on the precise role that radiation therapy plays in the management of bladder cancer.