Masaharu Sugiyama

Effect of Particle Size Distribution of the Feedstock Powder on the Microstructure of Bulk Metallic Glass Sprayed Coating by HVOF on Aluminum Alloy Substrate

The Fe-based bulk metallic glass (Fe43Cr16Mo16C15B10) sprayed coating with the thickness about 220%m was successfully deposited on an aluminum alloy (A5052) metal substrate using an HVOF (High Velocity Oxygen Fuel) spraying process. All sprayed coating has still kept the amorphous state after spraying. The Fe-based bulk metallic glass coating shows good adhesion to the aluminum alloy metal substrate, and has a high hardness with HMV 913~1120. It has been found that better properties can be obtained in the sprayed coating by using finer powder.

Effects of the Antitussive Fominoben (PB89) on Hypoxia in Chronic Obstructive Lung Disease: Comparison with Dextromethorphan Using a Double-Blind Method

We studied the effects of a non-narcotic, centrally acting antitussive, fominoben (PB89), on hypoxia in sixty patients suffering from chronic obstructive lung diseases (COLD), utilizing a double blind method and using the antitussive dextromethorphan as a reference drug. By the oral administration of a dose of 2 fominoben tablets (160 mg) three times a day for 2 weeks, a significant increase in arterial O2 pressure (PaO2), a decrease in arterial CO2 pressure (PaCO2), and a rise in pH were observed. However, alveolar-arterial O2 difference (A-aDO2) was not improved. On the other hand, after administration of a dose of 2 dextromethorphan tablets (30 mg) three times a day for 2 weeks, no increase in PaO2, no decrease in PaCO2 and no improvement in A-aDO2 were observed, although a rise in pH was seen. The increase in PaO2 by fominoben was marked in COLD with dyspnoea. No improvement of A-aDO2 despite a decrease in PaCO2 suggests that fominoben might increase alveolar ventilation, in spite of its effect as an antitussive, exerting a favourable effect on hypoxia. It is, therefore, speculated that the cough centre and the respiratory centre are capable of functioning independently of each other.