Masahiko Hiratsuka

Enzyme transistor circuits for reaction-diffusion computing

This paper explores the possibility of constructing massively parallel computing systems using molecular electronics technology. By employing specificity of biological molecules, such as enzymes, new integrated circuit architectures which are essentially free from interconnection problems could be constructed. To clarify the proposed concept, this paper presents a functional model of a basic biomolecular switching device called an enzyme transistor. The enzyme transistor is, in a sense, an artificial catalyst which selects a specific substrate molecule and transforms it into a specific product. Using this primitive function, various wire-free computing circuits can be realized. Examples described in this paper include basic analog amplifiers and digital logic circuits. This paper also presents the design of an excitable enzyme transistor circuit and demonstrates the potential of enzyme transistors for creating reaction-diffusion dynamics that performs useful computations in a massively parallel fashion.

A model of reaction-diffusion cellular automata for massively parallel molecular computing

This paper proposes an experimental model of artificial reaction-diffusion systems, which provides a foundation for constructing future massively parallel molecular computers. The key idea is to control redox-active molecules in solution, by an array of integrated microelectrodes and to realize artificially programmable reaction-diffusion dynamics in a very small amount of solution.

Toward Biomolecular Computers Using Reaction-Diffusion Dynamics

This article investigates a possibility of constructing massively parallel computing systems using molecular electronics technology. By employing the specificity of biological molecules, such as enzymes, new integrated circuit architectures that are free from interconnection problems could be constructed. To clarify the proposed concept, we present a functional model of an artificial catalyst device called an enzyme transistor. In this article, we develop artificial catalyst devices as basic building blocks for molecular computing integrated circuits, and explore the possibility of a new computing paradigm using reaction-diffusion dynamics induced by collective behavior of artificial catalyst devices. [Article copies are available for purchase from InfoSci-on-Demand.com]

A Model for Biomolecular Computing Using Enzyme Transistors

This paper explores the possibility of constructing massively parallel computing systems using molecular electronics technology. By employing specificity of biological molecules, such as enzymes, new integrated circuit architectures which are essentially free from interconnection problems could be constructed. To clarify the proposed concept, this paper presents a functional model of a molecular electronic device called an enzyme transistor. Using enzyme transistors, various wire-free computing circuits can be realized. Examples described in this paper include basic analog amplifiers and digital logic circuits. This paper also demonstrates the potential of enzyme transistors for creating reaction-diffusion dynamics that performs useful computations in a massively parallel fashion. Prominent examples discussed in this paper are: (i) Turing pattern formation and (ii) excitable wave propagation in a two-dimensional enzyme transistor system.

Enzyme transistor circuits for biomolecular computing

A model of an enzyme transistor, a three-terminal biomolecular switching device, is proposed. Ideally, an enzyme transistor can be regarded as an artificial enzyme whose catalytic activity is controlled by some effector molecule. In this paper, we show that various biomolecular circuits can be constructed with enzyme transistors. Also, a possible approach to the implementation based on electrical control of enzyme reactions is discussed.