Masahiko Okudaira

A STATISTICAL SURVEY OF DEEP FUNGUS INFECTION IN JAPAN

The authors report a statistical review of 546 cases of deep fungus infection which were observed in human post‐mortem materials. The materials were collected from 67,741 necropsy cases examined at the departments of pathology of 45 medical schools and three major hospitals in Japan between 1948 and 1961. The overall incidence of deep fungus infection was 0.8 per cent. The major types of infection were candidiasis, aspergillosis, cryptococcosis, actinomycosis and mucormycosis, in this order. All the geographic regions of deep fungus infection were represented. Apparent incident rates were high in the Kanto District which has many medical college hospitals and low in the Hokkaido area where the climate is rather cool. The yearly frequency, age distribution, site of infection and underlying conditions of the major types of fungus infection in Japan was described. From the analysis of the factors, it was concluded that the increase in number of cases with deep fungus infection was based not only upon the use of antibiotic and steroid therapy, but also on the increasing interest in fungus infection and the recent progress of investigating methods.

Histopathological Differentiation Between Candidaalbicansand Aspergillusfumigatusin Tissue Sections

Deep fungous infections of human beings have been reported by many investigators, and the increasing number of cases of severe dermatomycosis have been noted. These fungous affections which is still more advanced have not always been supported by optimal therapeuticeffects. This is one of the most prominent reason that these infections of man became a controversial topic. In recent years, various forms of far-advanced fungous infections frequently induced by antibiotic agents, have been described by the majority of the research

A Histopathological Study of Infectious Hepatitis with Needle Biopsy Materials, Especially a Cytological and Microspectrophotometric Observation

It has been widely accepted that infectious hepatitis is a self-directing disease and its pathogen is a virus.(l)*(e)l(s) Recently in Japan, there was an outbreak of infectious hepatitis in Okayama Prefecture (69 patients and its mortality was 13 per cent),(4) and isolation of its virus has been performed.(5)~(6) At the 4th Meeting of the International Society of Geographic Pathology, infectious hepatitis was the main subject, and many detailed studies were reported and discussed. The authors were fortunate in obtaining the opportunity to study 10 cases of infectious hepatitis in the Tokyo area. Needle biopsy materials of the liver were taken, and the materials were investigated histopathologically, with special stress layed on cytological and microspectrophotometric observations.