Masahiro Gomi
Osaka University
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Featured researches published by Masahiro Gomi.
Nephron | 1987
Hiromu Nakajima; Masahiro Gomi; Sayomi Iida; Norio Kono; Kaname Moriwaki; Seiichiro Tarui
Three patients with renal hypouricemia in the same family are described. Serum urate levels in the mother were in the low normal range and were below normal in her 2 sons. In all 3 patients, the ratios of renal urate clearance to creatinine clearance were abnormally elevated. Clear responses to either pyrazinamide or probenecid administration were observed in these ratios. These results suggest that these 3 patients had renal hypouricemia with normal reabsorption of urate as judged by the criteria for differentiating abnormalities in renal urate handling. This corresponds to the previously postulated mechanism as renal urate hypersecretion. Possible limitations to the diagnostic use of probenecid and pyrazinamide are also discussed.
Journal of Immunoassay | 1990
Mamiko Tsugawa; Kaname Moriwaki; Sayomi Iida; Hiroshi Fujii; Masahiro Gomi; Seiichiro Tarui; Ryota Yamane; Masao Fujimoto
A reliable and sensitive ELISA for cAMP in human plasma and urine is described, using a monoclonal antibody and a 96 well microtiter plate. Succinyl cAMP is conjugated to human serum albumin and adsorbed to the ELISA plate, giving an immobilized antigen approach which simplifies subsequent assay procedures. As low as 1.56 fmol/well of both plasma and urinary cAMP is measurable. Recoveries of added cAMP in plasma and urine were from 99% to 109%. Intra-assay coefficients of variation were less than 6.1% for plasma and 7.0% for urine samples. Inter-assay coefficients of variation for plasma and urine samples were less than 8.9% and 9.5%, respectively. There was a good correlation between the values obtained by ELISA and radioimmunoassay (RIA) (plasma: r = 0.94, n = 66; urine: r = 0.98, n = 64; nephrogenous cAMP: r = 0.96, n = 51).
Clinical Endocrinology | 1985
Masahiro Gomi; Sayomi Iida; Yoshiharu Itoh; Kaname Moriwaki; S. Kanayama; M. Namba; Seiichiro Tarui
A 53‐year‐old woman with Nelsons syndrome was treated with 600 mg sodium valproate daily. Her plasma ACTH was effectively decreased, whilst the response of plasma ACTH to corticotrophin‐releasing factor (CRF) was unaltered. The result of the CRF test suggested that sodium valproate, at least in the present patient, acted at the hypothalamic level.
Life Sciences | 1986
Kaname Moriwaki; Masahiro Gomi; Yoshiharu Itoh; Sayomi Iida; Mamiko Tsugawa; Seiichiro Tarui; Kaoru Fuji; Manabu Node; Tetsuya Kajimoto
In an in vitro bioassay system for adrenocorticotropic hormone using isolated rat adrenal cells, kaurenol, a diterpene alcohol, stimulated corticosterone production and augmented the steroidogenic effect of adrenocorticotropin or forskolin, dose-dependently. Kaurenol had no effect on cyclic AMP production by the cells. The diterpene also had no stimulatory effect on the adrenal adenylate cyclase activity in a cell free system. The results suggest that this particular diterpene exerts a steroidogenic effect through a mechanism independent of cyclic AMP generation.
Hormone Research in Paediatrics | 1984
Sayomi Iida; Yoshiharu Itoh; Masahiro Gomi; Kaname Moriwaki; Seiichiro Tarui
We have demonstrated the presence of ACTH-potentiating factors in porcine thymus which contained neither biologically active nor radioimmunoassayable ACTH. The factors were acidic and heat stable in nature, and were present in heterogeneous forms having various molecular weight. Purification of the factors with small molecular weights was performed using reversed-phase high-performance liquid chromatography following gel filtration and cation-exchange chromatography. A purified factor exerted dose-dependent ACTH-potentiating activity. Loss of the ACTH-potentiating activity of purified factors by treatment with carboxypeptidase Y indicated their peptidic nature. ACTH-potentiating activity was readily observable after preincubating the adrenal cells with the thymic extract. The enhancement of ACTH-induced steroidogenesis by the factors was observed in the presence of bacitracin at a concentration to prevent ACTH degradation. Therefore, the existence of potentiating mechanisms other than inhibition of ACTH proteolysis was indicated.
The Journal of Clinical Endocrinology and Metabolism | 1985
Sayomi Iida; Masahiro Gomi; Kaname Moriwaki; Yoshiharu Itoh; Kazuhiko Hirobe; Yuji Matsuzawa; Shuichi Katagiri; Takeshi Yonezawa; Seiichiro Tarui
Cancer Research | 1990
Masahiro Gomi; Kaname Moriwaki; Shuichi Katagiri; Yoshiyuki Kurata; E. Brad Thompson
The Journal of Clinical Endocrinology and Metabolism | 1990
Sayomi Iida; Yoshihisa Nakamura; Hiroshi Fujii; Junichi Nishimura; Mamiko Tsugawa; Masahiro Gomi; Junichi Fukata; Seiichiro Tarui; Kaname Moriwaki; Teruo Kitani
Endocrinology | 1990
Hiroshi Fujii; Sayomi Iida; Mamiko Tsugawa; Masahiro Gomi; Kaname Moriwaki; Seiichiro Tarui
The Journal of Clinical Endocrinology and Metabolism | 1993
Hiroshi Fujii; Sayomi Iida; Masahiro Gomi; Mamiko Tsugawa; Teruo Kitani; Kaname Moriwaki