Masahiro Matsunaka

Beneficial Effect of Helicobacter pylori Eradication in Dermatologic Diseases

A relationship between skin diseases, particularly rosacea and chronic urticaria, and H. pylori infection has been suggested.

Stratum corneum in psoriasis vulgaris. A transmission and scanning electron microscopic study

This is a transmission and scanning electron microscopic study of stratum cerneum in psoriasis vulgaris.

Complicated case of Paget disease after nipple conservative operation of mammary cancer with multiple Bowen disease.

We report herein a case of mammary Pagets disease complicated by multiple Bowens disease in a patient who had received successive chemotherapy during follow-up for surgical resection of breast cancer preserving the nipple 8 years earlier.Subject: The patient was a 52-year-old housewife.In 1988, she underwent left breast cancer resectomy preserving the nipple at another hospital.In 1991, erosion on the left nipple was noted.In 1993, erythema on the inner portion of the right breast was noticed.In 1995, since erosion of the left nipple expanded to the areola and was accompanied by gradual extension of erythema on the inner portion of the right breast as well as dispersion of erythema on other parts of the trunk, the patient consulted a local dermatologist.Because Bowens disease was diagnosed by biopsy of the left areola with erythema due to suspected Pagets disease, the patient was reffered to our hospital.At our department, biopsy of the left areola as well as the erythematous area of the trunk was performed again.On histopathological examination, the patient was diagnosed with mammary Pagets disease and multiple Bowens disease.The findings of the biopsy performed at the other hospital also indicated Pagets disease.

Observation of MHE by thermography. Follow-up of head malignant hemangioendothelioma by thermography.

We already reported this case as a malignant hemangioendothelioma (MHE) case where effects of one shot intraarterial recombinant interleukin-2 (IL-2) injection therapy were remarkable compared to conventional local injection of IL-2 or intraarterial therapy. We first used thermography to observe the therapy course of this case. The patient was 77-year-old female with MHE at the left forehead. At the first examination, tumor region and its circumferential erythema demonstrated high temperature on thermography. After one shot intraarterial IL-2 injection for 17 times, high temperature region on thermography was markedly reduced and the erythema disappeared. Pathological finding of the region revealed no tumor cells. Since thermography could detect aggravation of the disease due to discontinuance of thetherapy at an early stage as enlargement of the high temperature region, the method was estimated valuable asasupplemental diagnostic method for observation of the disease course.