Masahiro Yanase

Nerve growth factor-mediated sexual differentiation of the rat hypothalamus

Injection of antibody to nerve growth factor into the cerebral lateral ventricle blocked testosterone-induced behavioral defeminization of neonatal female rats. When tested as adults following ovariectomy and combined estrogen-progesterone treatment, the injected animals showed a significantly higher lordosis quotient than the testosterone-treated, normal rabbit serum-infused controls. Failure of vaginal opening and clitoral enlargement manifested the well-documented masculinizing effect of testosterone on the genitalia in the experimental as well as the control animals. Estrogen sensitivity of hypothalamic neurons which are responsible for the induction of lordosis was retained in the experimental animals. Recordings of the antidromic action potentials from neurons in the ventromedial nucleus of the hypothalamus following stimulation of the midbrain central gray revealed that estrogen decreased the antidromic activation threshold and shortened the absolute refractory period of the hypothalamic efferents along with the estrogen-induced behavioral activation in the experimental animals. In the control group, the estrogen-induced neuronal activation was lost altogether with the behavioral activation.

Effect of Low Power Laser Treatment and Linearly Polarized Light Irradiation Treatment on Rheumatoid Arthritis

Low Power laser treatment and linearly polarized light irradiation treatment were applied to patients with chronic rheumatoid arthritis(RA). Energy density of Ga—Al—As diode laser is 57-114J/cm2, and that of linearly polarized light irradiation is 25.5.J/cm2. Power level of laser beam is 60mW C.W, and that of incoherent polarized beam is 1250mW. The wave lenght of laser light is 830nm, and that of polarized incoherent light is 600-1600nm. 61 inplammatory joints from 52 RA patients were examined in this study. These inflammatory joints with pain were treated by 2 different types of beams. Both treatments had painrelieving effect. The effective ratio of laser treatment was about 65.6% and that of incoherent polarized light treatment was 32.8%. All of the effective cases treated by incoherent polarized light irradiation teratment were also relieved pain by laser treatment. Laser light has some characteristics, directivity, monochromaticity, magnetooptic effect, polarization, and coherency. Wound healing and pain relieving effects of linearly and right—hand circularly polarized light irradiation were reported. Furthermore this study suggested the coherency of light had a very important role of stimulation to living body. 【諸言】低出力 レーザー療法(低 反応 レベル レーザー療法LLLT)の 鎮痛作用は、 レーザ ー光の物理的な特質によって生体反応が刺激さ れた結果 もた らされるものである。 しか し、 レ ーザー光の基本的牲質であるコヒーレント性 、 偏光性、指向性、高エネルギー密度性、電磁場 集中性などの中で鎮 痛効果 に必要 な要素は果た して何かなど漠然とした感がある。そこで、波 長域が類似 し、直線偏光性を有 し、スポッ ト照 射を実現させることで高エネルギー密度性をも たせたスポット型直線偏光赤外線治療(SLT) とLLLTの 鎮痛作用を臨床的に比較 し、両者

Acute pain-relief effects of low power laser irradiation and thermogram of rheumatoid arthritis patients

The relationship of acute pain-relief effects of low power (Ga-Al-As Diode) laser irradiation and thermogram of 19 Rheumatoid Arthritis patients was examined. The maximum skin temperature (MST) level of 10 patients (52.6%) dropped immediately after irradiation. Laser treatment was effective in 90% of these cases. The MST level of 8 patients (42.1%) rose immediately after irradiation. Laser treatment was ineffective in 5 of 8 cases. The effective ratio of irradiation of patients whose MST levels dropped was statistically high. (P 0.05) When MST levels rise, irradiation would be ineffective. The thermogram in cases at 10 minutes after irradiation showed no relationship to acute pain-relief effects of laser therapy.