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Journal of Chromatography B: Biomedical Sciences and Applications | 1982

Analysis of organic acids in the hearts of patients with idiopathic cardiomyopathy by gas chromatography—mass spectrometry

Shin-Ichi Haraguchi; Masahisa Terasawa; Hironori Toshima; Isamu Matsumoto; Tomiko Kuhara; Toshihiro Shinka

Organic acids in the hearts of patients with idiopathic cardiomyopathy, obtained by biopsy, were studied using gas chromatography--mass spectrometry. The profiling of organic acids was compared among eight cases of hypertrophic cardiomyopathy, three cases of congestive cardiomyopathy, and nine cases of other heart diseases, which were regarded as controls. It was found that almost all organic acids, especially deoxyaldonic acids of 2-deoxytetronic acid, 2,3-dideoxypentonic acid, 3-deoxy-2-C-(hydroxymethyl)tetronic acid, 3-deoxyerythropentonic acid and 3-deoxy-2-C-(hydroxymethyl)erythropentonic acid, were accumulated in large amounts in the heart in congestive cardiomyopathy, while these acids were decreased in hypertrophic cardiomyopathy. It was therefore suggested that deoxyaldonic acid metabolism in the heart in congestive cardiomyopathy is quite different from that in hypertrophic cardiomyopathy.


Japanese Heart Journal | 1986

Relationship of Exercise or Pacing Induced ST-Segment Depression and Myocardial Lactate-Metabolism in Patients with-Hypertrophic Cardiomyopathy

Yasuhiro Ogata; Kouji Hiyamuta; Masahisa Terasawa; Yasuo Ohkita; Hisatoshi Bekki; Yoshinori Koga; Hironori Toshima


Japanese Heart Journal | 1985

An Advanced Form of Familial Hypertrophic Cardiomyopathy Showing Massive Myocardial Fibrosis with Intramural Small Arterial Thickening

Kyo Adachi; Hiroyuki Tanaka; Masahiko Ogata; Yoshinao Yamashita; Kenzo Sugi; Masahisa Terasawa; Katsutoshi Ohta; Yoshinori Koga; Hironori Toshima; Toru Umezu; Minoru Morimatsu; Nagaomi Takahashi


Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine | 1985

[A case of apical hypertrophic cardiomyopathy associated with atrial septal defect--a comparison of histopathological findings in the endomyocardial specimen obtained by biopsy and the specimen of the hypertrophied portion obtained surgically].

Kyo Adachi; Hiroyuki Tanaka; Yoshinao Yamashita; Masahiko Ogata; Masahisa Terasawa; Yoshinori Koga; Hironori Toshima


Japanese Circulation Journal-english Edition | 1986

8) A SIGNIFICANCE OF THE WALL THICKNESS OF INTRAMURAL CORONARY VESSELS ESPECIALLY IN HYPERTROPHIC CARDIOMYOPATHY

Hironori Toshima; Hiroyuki Tanaka; Kyo Adachi; Masahiko Ogata; Yoshinao Yamashita; Masahisa Terasawa; Yoshinori Koga


Japanese Circulation Journal-english Edition | 1985

20)RELATING FACTORS OF DILATED CARDIOMYOPATHY OFFER DIFFERENT CLINICO-PATHOLOGICAL FINDINGS : THE 8th CONFERENCE ON CARIDIOMYOPATHY

Kyo Adachi; Masahiko Ogata; Yoshinao Yamashita; Hiroyuki Tanaka; Masahisa Terasawa; Hironori Toshima; Yoshinori Koga


Japanese Circulation Journal-english Edition | 1985

13)EVALUATION OF MITOCHONDRIAL INTRAMEMBRANOUS PROTEIN PARTICLES OF THE BIOPSIED HUMAN MYOCARDIUM BY FREEZE-FRACTURE METHOD : THE 7th CONFERENCE ON CARDIOMYOPATHY

Yoshinao Yamashita; Hiroyuki Tanaka; Kyo Adachi; Masahisa Terasawa; Hironori Toshima; Yoshinori Koga


Japanese Circulation Journal-english Edition | 1985

EVALUATION OF THE BIOPSIED MYOCARDIUM IN CARDIOMYOPATHY BY FREEZE-FRACTURE METHOD : Myocardial Disease (I) : FREE COMMUNICATIONS (I) : PROCEEDINGS OF THE 49th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY

Yoshinao Yamashita; Kyo Adachi; Hiroyuki Tanaka; Masahisa Terasawa; Yoshinori Koga; Hironori Toshima


Japanese Circulation Journal-english Edition | 1985

14)CORONARY CIRCULATION OF HYPERTROPHIC CARDIOMYOPATHY : REACTION TO DIPYRIDAMOLE : THE 8th CONFERENCE ON CARIDIOMYOPATHY

Masayoshi Shimamatsu; Hisao Ikeda; Masayoshi Yoh; Kohji Hiyamuta; Hisashi Ushijima; Masahisa Terasawa; Hisatoshi Bekki; Yasuo Ohkita; Hironori Toshima; Yoshinori Koga; Fumihiko Utsu


Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine | 1984

[Clinical features in familial brady-arrhythmia of an adult onset].

Fujiyama M; Hisao Ikeda; Furuta Y; Matsumura J; Tanabe A; Ohbayashi J; Masahisa Terasawa; Kyo Adachi; Saito Y; Hironori Toshima

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