Masaki Hayashi

Oxidation of alcohols to carbonyl compounds with diisopropyl azodicarboxylate catalyzed by nitroxyl radicals.

A nitroxyl-radical-catalyzed oxidation of alcohols using diisopropyl azodicarboxylate (DIAD) as the terminal oxidant is reported. A variety of primary and secondary alcohols including aliphatic, benzylic, and allylic alcohols are efficiently oxidized to their corresponding aldehydes and ketones without overoxidation to carboxylic acid. 1,2-Diols are oxidized to hydroxyl ketones or diketones depending on the amount of DIAD used.

Oxidative conversion of silyl enol ethers to α,β-unsaturated ketones employing oxoammonium salts.

The oxidative conversion of silyl enol ethers to α,β-unsaturated ketones using a less-hindered class of oxoammonium salts (AZADO(+)BF(4)(-)) is described. The reaction proceeds via the ene-like addition of oxoammonium salts to silyl enol ethers.

Synthesis of thromboxane A2 analog DL-(9,11), (11,12)-dideoxa-(9,11)-epithio-(11,12)-methylene-thromboxane A2

Abstract A synthesis of the thromboxane A 2 analog, dl -(9,11), (11,12)-dideoxa-(9,11)-epithio-(11,12)-methylene-thromboxane A 2 is described.

Synthesis of 9α,11α-thiathromboxane A2 methyl ester

Abstract The synthesis of thromboxane A 2 (TXA) analogue, 9α,11α-thia-TXA 2 methyl ester 2 , in which the oxygen atom in the oxetane ring of TXA 2 was replaced by a sulfur atom, is described.

Synthesis of thromboxane A2 analog DL-(9,11), (11,12)-dideoxa-(9,11)-methylene-(11,12)-epithio-thromboxane A2 methyl ester

Abstract A synthesis of the thromboxane A2 analog, dl -(9,11) ,(11,12)-dideoxa-(9,11)-methylene-(11,12)-epithio-thromboxane A2 methyl ester 2 , is described.

A convenient route to (+)-(9,11)-epithia-(11,12)-methano-thromboxane A2, from prostaglandin E2, methyl ester

(+)-(9,11)-Epithia-(11,12)-methano-thromboxane A2 which is of great importance in thromboxane research, has been synthesized from prostaglandin E2 methyl ester.

The synthesis of new aromatic prostacyclin analog

Abstract The new aromatic prostacyclin analog 3a and 3b were synthesized from the allylic alcohol 5 in high regio- and stereoselectivity.

Synthesis of thromboxane A2 analog dl-(9,11),(11,12)-dideoxa-(9,11),(11,12)-dimethylene thromboxane A2

The thromboxane A2 analog, dl-(9,11),(11,12)-dideoxa-(9,11),(11,12)-dimethylene thromboxane A2 (TX A2) has been synthesized; the compound showed high agonist activities on platelet aggregation and the aorta contracting activities.

Synthesis of 11β-3H-prostaglandin E2

Abstract 11β-3H-Prostaglandin E2 was synthesized by the stereoselective reduction of the PGD2 derivative 2 using sodium borotritide.