Masami Kohchi
Hoffmann-La Roche
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Publication
Featured researches published by Masami Kohchi.
Bioorganic & Medicinal Chemistry Letters | 2000
Kazunao Masubuchi; Mikio Taniguchi; Isao Umeda; Kazuo Hattori; Hitomi Suda; Yasunori Kohchi; Yoshiaki Isshiki; Toshiya Sakai; Masami Kohchi; Michio Shirai; Hisafumi Okabe; Masayuki Sudoh; Toshikazu Yamazaki; Nobuo Shimma
A novel Candida albicans chitin synthase 1 (CaChs1) inhibitor, RO-41-0986 (1) was discovered by random screening. Systematic modification led to the identification of a highly potent CaChs1 inhibitor, RO-09-3024 (2), having strong antifungal activity against Candida spp. in vitro.
Bioorganic & Medicinal Chemistry Letters | 2001
Kazunao Masubuchi; Takehiro Okada; Masami Kohchi; Takeshi Murata; Masao Tsukazaki; Osamu Kondoh; Toshikazu Yamazaki; Yasuko Satoh; Yoshinori Ono; Toshiyuki Tsukaguchi; Kazuko Kobayashi; Naomi Ono; Tomoaki Inoue; Ikuo Horii; Nobuo Shimma
Highly potent 1,3-beta-D-glucan synthase inhibitors 10, 11 and 13 have been identified by the chemical modification of the fungicidal macrocyclic lipopeptidolactone, RO-09-3655 (1), isolated from the cultured broth of Deuteromycotinia spp. D-Ornithine derivative (10) showed improved antifungal activity in the systemic candidiasis model in mice and reduced hepatotoxicity in vitro, as compared with 1.
Archive | 2004
Masahiro Sakaitani; Kazunao Masubuchi; Masami Kohchi; Ikumi Hyoudoh; Kohsuke Asoh; Miyuki Asai
Archive | 2001
Masami Kohchi; Kazunao Masubuchi; Takeshi Murata; Takehiro Okada; Nobuo Shimma
Archive | 2005
Yoshiaki Isshiki; Yasunori Kohchi; Eisaku Mizuguchi; Hitoshi Iikura; Yasuaki Matsubara; Shinji Tsujii; Nobuo Shimma; Masanori Miwa; Satoshi Aida; Masami Kohchi; Takeshi Murata; Kosuke Aso
Archive | 2005
Yoshiaki Isshiki; Yasunori Kohchi; Eisaku Mizuguchi; Hitoshi Iikura; Yasuaki Matsubara; Shinji Tsujii; Nobuo Shimma; Masanori Miwa; Satoshi Aida; Masami Kohchi; Takeshi Murata; Kosuke Aso
Archive | 2005
Satoshi Aida; Kosuke Aso; Hitoshi Iikura; Yoshiaki Isshiki; Masami Kohchi; Yasunori Kohchi; Yasuaki Matsubara; Masanori Miwa; Eisaku Mizuguchi; Takeshi Murata; Nobuo Shimma; Shinji Tsujii
Archive | 2005
Yoshiaki Isshiki; Yasunori Kohchi; Eisaku Mizuguchi; Hitoshi Iikura; Yasuaki Matsubara; Shinji Tsujii; Nobuo Shimma; Masanori Miwa; Satoshi Aida; Masami Kohchi; Takeshi Murata; Kosuke Aso
Archive | 2004
Masahiro Aoki; Masami Kohchi; Kazunao Masubuchi; Eisaku Mizuguchi; Takeshi Murata; Hiroaki Ohkuma; Takehiro Okada; Masahiro Sakaitani; Nobuo Shimma; Takahide Watanabe; Mieko Yanagisawa; Yuri Yasuda
Archive | 2001
Masami Kohchi; Kazunao Masubuchi; Takeshi Murata; Takehiro Okada; Nobuo Shimma
