Masami Okuno

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International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology | 1988

Hideo Saji; Iwoa Nakatsuka; Masami Okuno; Akira Yokoyama

A radioactive or non-radioactive 2-iodobutyrophenone derivative the formula: ##STR1## wherein X is a radioactive or non-radioactive iodine atom. The radioactive compound has a high affinity for dopamine receptors and is very useful as a radioactive diagnostic agent and as a radiopharmaceutical, and the non-radioactive compound also as a high affinity for dopamine receptors and is very useful as a neuroleptic, a sedative, an anodyne, a tranquilizer, etc.

International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology | 1990

Iwao Nakatsuka; Masami Okuno; Kunio Shiba; Akira Yoshitake

The present invention relates to a novel radioactive benzodiazepine derivative represented by the formula: ##STR1## wherein R is hydrogen or a lower alkyl; X* is radioactive iodine or bromine; Y is hydrogen or a halogen; and Z is a halogen or nitro group; and the salt thereof. The compound of the present invention enables to non-invasively detect the presence of benzodiazepine receptors in human or animal brains, other organs or tissues. Additionally, it enables to dynamically trace the change in receptor concentration either. It is very useful as a radioactive diagnostic agent for nuclear medicine in vitro or in vivo or as a radio-pharmaceutical.

Life Sciences | 1987