Masanobu Takahara

Relationship between Grade of Varicocele and the Response to Varicocelectomy

Background: Although several studies indicate that larger varicoceles are associated with greater impairment of spermatogenesis, others suggest that the response to surgery is independent of varicocele size. In order to elucidate these seeming contradictions, correlations between the preoperative evaluation of varicoceles and improvement in semen quality after varicocelectomy were investigated.

Klinefelter's syndrome with prepenile scrotum

Two cases of Klinefelters syndrome with prepenile scrotum were presented. They underwent the operation for prepenile scrotum according to Glenn and Andersons method. Thereafter urethroplasty was performed in each case. The decrease in response to testosterone in the target organ was noticed in 1 patient, suggesting that some androgen resistance in this case was attributable in part to anomaly of genitalia.

A Case of 48, XXYY Klinefelter's Syndrome with Incurable Skin Ulcer

A 40-year-old male was referred to the Chiba University Hospital for hypogonadism. He showed many of the phenotypic features of Klinefelters syndrome. Cytogenetic studies revealed a 48,XXYY karyotype. The significance of the association of this karyotype with incurable skin ulcer is discussed.