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Dive into the research topics where Masanori Ishida is active.

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Featured researches published by Masanori Ishida.


European Journal of Radiology | 2013

Comparison of pure and hybrid iterative reconstruction techniques with conventional filtered back projection: image quality assessment in the cervicothoracic region.

Masaki Katsura; Jiro Sato; Masaaki Akahane; Izuru Matsuda; Masanori Ishida; Koichiro Yasaka; Akira Kunimatsu; Kuni Ohtomo

OBJECTIVES To evaluate the impact on image quality of three different image reconstruction techniques in the cervicothoracic region: model-based iterative reconstruction (MBIR), adaptive statistical iterative reconstruction (ASIR), and filtered back projection (FBP). METHODS Forty-four patients underwent unenhanced standard-of-care clinical computed tomography (CT) examinations which included the cervicothoracic region with a 64-row multidetector CT scanner. Images were reconstructed with FBP, 50% ASIR-FBP blending (ASIR50), and MBIR. Two radiologists assessed the cervicothoracic region in a blinded manner for streak artifacts, pixilated blotchy appearances, critical reproduction of visually sharp anatomical structures (thyroid gland, common carotid artery, and esophagus), and overall diagnostic acceptability. Objective image noise was measured in the internal jugular vein. Data were analyzed using the sign test and pair-wise Students t-test. RESULTS MBIR images had significant lower quantitative image noise (8.88 ± 1.32) compared to ASIR images (18.63 ± 4.19, P<0.01) and FBP images (26.52 ± 5.8, P<0.01). Significant improvements in streak artifacts of the cervicothoracic region were observed with the use of MBIR (P<0.001 each for MBIR vs. the other two image data sets for both readers), while no significant difference was observed between ASIR and FBP (P>0.9 for ASIR vs. FBP for both readers). MBIR images were all diagnostically acceptable. Unique features of MBIR images included pixilated blotchy appearances, which did not adversely affect diagnostic acceptability. CONCLUSIONS MBIR significantly improves image noise and streak artifacts of the cervicothoracic region over ASIR and FBP. MBIR is expected to enhance the value of CT examinations for areas where image noise and streak artifacts are problematic.


Legal Medicine | 2011

Intravascular gas distribution in the upper abdomen of non-traumatic in-hospital death cases on postmortem computed tomography.

Masanori Ishida; Wataru Gonoi; Kazuchika Hagiwara; Yutaka Takazawa; Masaaki Akahane; Masashi Fukayama; Kuni Ohtomo

OBJECTIVES To investigate the occurrence of intravascular gas in the liver, kidneys, spleen, and pancreas by postmortem computed tomography (PMCT) in cases of non-traumatic in-hospital deaths and elucidate the relationship between the PMCT data and clinical information or autopsy results. METHODS The study included 45 cadavers of patients who died while receiving treatment in our academic tertiary-care hospital between April and December 2009. All subjects underwent PMCT and conventional autopsy. The appearance of postmortem gas in the liver, kidney, spleen, and pancreas was assessed using PMCT and scored using a subjective scale (liver, L0-L3; kidney, K0-K2; spleen, S0-S1; and pancreas, P0-P1), and the distribution of gases in the vessels of the liver (arteries, veins, and portal veins) was analyzed. The relationship between the gas score and time elapsed since death, cardiopulmonary resuscitation (CPR), administration of antibiotics, a history of bacteremia, or cause of death was assessed statistically. RESULTS Positive correlations were found between administration of CPR and liver and kidney gas scores (P=0.008 and 0.002, respectively), but not with spleen and pancreas gas (P=0.291 and 0.535, respectively). No significant relationship between distribution of gas in the vessels of the liver and CPR was found. No other significant correlations between gas and any of the other parameters described above were found. While significant correlations were detected in no-CPR cases between liver gas, kidney gas, spleen gas, and pancreas gas (P<0.001 for all six combinations), no correlation between these parameters was detected in the CPR cases. CONCLUSIONS The present study was the first statistical analysis of intravascular gas in the liver, kidneys, spleen, and pancreas by using PMCT in non-traumatic in-hospital death cases. The results showed that PMCT in the presence and absence of CPR reveals differences in intraorgan gas distribution. In addition, the detection of intraorgan gas on PMCT cannot be used to predict time elapsed since death, and it is not affected by the administration of antibiotics, a history of bacteremia, and cause of death. Awareness of these postmortem changes is important for the accurate interpretation of PMCT results.


Legal Medicine | 2011

Hypostasis in the heart and great vessels of non-traumatic in-hospital death cases on postmortem computed tomography: Relationship to antemortem blood tests

Masanori Ishida; Wataru Gonoi; Kazuchika Hagiwara; Yutaka Takazawa; Masaaki Akahane; Masashi Fukayama; Kuni Ohtomo

OBJECTIVES The purpose of this study was to investigate hypostasis in the heart and great vessels (HHGV) by postmortem computed tomography (PMCT) in cases of non-traumatic in-hospital deaths and to analyze relationships between clarity of HHGV and antemortem blood markers. MATERIAL AND METHODS The study included 31 cadavers of patients who died while receiving treatment in our academic tertiary-care hospital between April and December 2009. Antemortem blood tests including both hematological and blood coagulation markers were performed within 48h before death, and PMCT and conventional autopsies were performed. The findings of HHGV were assessed in the following six locations: the superior vena cava, right atrium, right ventricle, thoracic aorta, left atrium, and left ventricle. The clarity of HHGV on PMCT was divided into two groups using attenuation of the left ventricular wall as a reference: no/obscure HHGV group and clear HHGV group. The relationships between clarity of HHGV and six blood markers [red blood cell (RBC) count, hemoglobin (Hb), hematocrit (Ht), prothrombin percentage activity (PT%), activated partial thromboplastin time (aPTT), and fibrinogen] were evaluated statistically. RESULTS We observed no/obscure HHGV in 14 patients (45%) and clear HHGV in 17 patients (55%). The level of fibrinogen in clear HHGV group was significantly higher than in no/obscure HHGV group (P=0.029). No relationships were found between clarity of HHGV and other five blood markers. CONCLUSION HHGV is a common PMCT finding. Clear HHGV on PMCT was related to higher level of fibrinogen in non-traumatic in-hospital death cases.


PLOS ONE | 2013

Heart Wall Is Thicker on Postmortem Computed Tomography Than on Ante Mortem Computed Tomography: The First Longitudinal Study

Hidemi Okuma; Wataru Gonoi; Masanori Ishida; Yukako Shintani; Yutaka Takazawa; Masashi Fukayama; Kuni Ohtomo

Objective To evaluate the postmortem changes of the heart wall on postmortem (PM) computed tomography (CT) in comparison with those on ante mortem CT (AMCT), and in comparison with the pathological findings, obtained in the same patients. Materials and Methods We studied 57 consecutive patients who had undergone AMCT, PMCT, and pathological autopsy in our tertiary care hospital between April 2009 and December 2010. PMCT was performed within 20 hours after death, followed by pathological autopsy. The cardiac chambers were measured at five sites on both AMCT and PMCT by two board-certified radiologists who were not provided with clinical information. The differences in heart wall thickness between AMCT with and without contrast medium, between AMCT and PMCT, and between PMCT and pathological anatomy were evaluated statistically. Confounding factors of postmortem change such as gender, presence of arteriosclerosis, the organ related to cause of death, age, and elapsed time since death were examined statistically. Results No significant differences were observed on AMCT in comparison of contrasted and non-contrasted images. The heart wall was significantly thicker on PMCT than on AMCT (p < 0.0001) at all five measurement sites. The heart wall was significantly thicker on PMCT than on pathology specimens when measured in accordance with pathological standard mensuration. However, no significant difference was observed between PMCT measurements and those of pathology specimens at any site when the papillary muscles and epicardial fat were included. No significant association was found between postmortem change in heart wall thickness and gender, presence of arteriosclerosis, the organ related to cause of death, age, or elapsed time since death. Conclusion This is the first longitudinal study to confirm greater thickness of heart wall on postmortem images compared with ante mortem images, in the same patients. Furthermore, the postmortem changes on CT were supported by the pathological findings.


Legal Medicine | 2011

Postmortem changes of the thyroid on computed tomography

Masanori Ishida; Wataru Gonoi; Kazuchika Hagiwara; Yutaka Takazawa; Masaaki Akahane; Masashi Fukayama; Kuni Ohtomo

OBJECTIVE To evaluate the radiographic features of the thyroid on postmortem computed tomography (PMCT). METHODS We studied the bodies of 32 subjects who had been treated and subsequently died in our tertiary care hospital between April and December 2009. The thyroids were imaged by antemortem computed tomography (AMCT), PMCT, and examined by conventional autopsy. Differences between the radiographic features of the thyroid on AMCT and PMCT, and time since AMCT were evaluated statistically. RESULTS CT values of the thyroid decreased after death with an average of 114.2 Hounsfield Units (HUs) on AMCT vs. 107.7HU on PMCT (paired t-test, P=0.023). There was no correlation between the elapsed time from AMCT and differences of CT values of the thyroid on AMCT and PMCT (Spearmans rank correlation test, P>0.05). CONCLUSION We showed that CT values of the thyroid decreased after death.


PLOS ONE | 2015

Brain Swelling and Loss of Gray and White Matter Differentiation in Human Postmortem Cases by Computed Tomography

Go Shirota; Wataru Gonoi; Masanori Ishida; Hidemi Okuma; Yukako Shintani; Hiroyuki Abe; Yutaka Takazawa; Masako Ikemura; Masashi Fukayama; Kuni Ohtomo

The purpose of this study was to evaluate the brain by postmortem computed tomography (PMCT) versus antemortem computed tomography (AMCT) using brains from the same patients. We studied 36 nontraumatic subjects who underwent AMCT, PMCT, and pathological autopsy in our hospital between April 2009 and December 2013. PMCT was performed within 20 h after death, followed by pathological autopsy including the brain. Autopsy confirmed the absence of intracranial disorders that might be related to the cause of death or might affect measurements in our study. Width of the third ventricle, width of the central sulcus, and attenuation in gray matter (GM) and white matter (WM) from the same area of the basal ganglia, centrum semiovale, and high convexity were statistically compared between AMCT and PMCT. Both the width of the third ventricle and the central sulcus were significantly shorter in PMCT than in AMCT (P < 0.0001). GM attenuation increased after death at the level of the centrum semiovale and high convexity, but the differences were not statistically significant considering the differences in attenuation among the different computed tomography scanners. WM attenuation significantly increased after death at all levels (P<0.0001). The differences were larger than the differences in scanners. GM/WM ratio of attenuation was significantly lower by PMCT than by AMCT at all levels (P<0.0001). PMCT showed an increase in WM attenuation, loss of GM–WM differentiation, and brain swelling, evidenced by a decrease in the size of ventricles and sulci.


Korean Journal of Radiology | 2015

Common Postmortem Computed Tomography Findings Following Atraumatic Death: Differentiation between Normal Postmortem Changes and Pathologic Lesions

Masanori Ishida; Wataru Gonoi; Hidemi Okuma; Go Shirota; Yukako Shintani; Hiroyuki Abe; Yutaka Takazawa; Masashi Fukayama; Kuni Ohtomo

Computed tomography (CT) is widely used in postmortem investigations as an adjunct to the traditional autopsy in forensic medicine. To date, several studies have described postmortem CT findings as being caused by normal postmortem changes. However, on interpretation, postmortem CT findings that are seemingly due to normal postmortem changes initially, may not have been mere postmortem artifacts. In this pictorial essay, we describe the common postmortem CT findings in cases of atraumatic in-hospital death and describe the diagnostic pitfalls of normal postmortem changes that can mimic real pathologic lesions.


American Journal of Forensic Medicine and Pathology | 2014

Fluid in the airway of nontraumatic death on postmortem computed tomography: relationship with pleural effusion and postmortem elapsed time.

Masanori Ishida; Wataru Gonoi; Kazuchika Hagiwara; Hidemi Okuma; Yukako Shintani; Hiroyuki Abe; Yutaka Takazawa; Kuni Ohtomo; Masashi Fukayama

AbstractTo evaluate radiographic features of endotracheal/endobronchial fluid in the airway (FA) observed on postmortem computed tomography (PMCT). We studied 164 subjects who died at our hospital between April 2009 and September 2012. Fluid in the airway was considered positive when fluid was identified in the lumen of 1 of the 2 main bronchi in continuity with a segmental bronchus. Pleural effusion and atelectasis/consolidation of the lung lower lobes were also evaluated. Fluid in the airway was observed in 60 (71%) of 84 subjects with unilateral or bilateral pleural effusion, and in 44 (55%) of 80 subjects without pleural effusion (P = 0.029). Of the latter, 41 (93%) had atelectasis/consolidation of the lower lung lobes. Among subjects without pleural effusion, average times after death to PMCT of subjects with and without FA were 501 and 314 minutes, respectively (P = 0.01). Time-course analysis showed that cases with FA on PMCT largely correlated with time after death (R2 = 0.7966). Fluid in the airway is frequently observed on PMCT in subjects with pleural effusion or atelectasis/consolidation of the lung. No FA in subjects without pleural effusion correlated to shorter times after death. In addition, FA frequency on PMCT increased over time after death.


PLOS ONE | 2014

Comparison of Attenuation of Striated Muscle between Postmortem and Antemortem Computed Tomography: Results of a Longitudinal Study

Hidemi Okuma; Wataru Gonoi; Masanori Ishida; Go Shirota; Yukako Shintani; Hiroyuki Abe; Masashi Fukayama; Kuni Ohtomo

Objective We evaluated the postmortem changes of striated muscle by comparing computed tomography (CT) images obtained postmortem and antemortem in the same patients. Materials and Methods We studied 33 consecutive patients who underwent antemortem CT, postmortem CT, and pathological autopsy in our tertiary care hospital between April 2009 and December 2010. Postmortem CT was performed within 20 h after death and was followed by pathological autopsy. Pathological autopsy confirmed the absence of muscular diseases such as amyotrophic lateral sclerosis, muscular dystrophy, myositis, and myasthenia, in all of the patients. The CT attenuation values of four cardiac muscle sites (anterior wall of the left ventricle, left ventricular free wall, posterior wall of the left ventricle, and the ventricular septum) and two skeletal muscle sites (the pectoralis major muscle and the erector spinae muscle) were compared between antemortem and postmortem CT using paired t test. Results Striated muscle had significantly greater attenuation on postmortem CT than on antemortem CT (P<0.001) in all six tissue sites. No significant association was found between postmortem change in the CT attenuation of striated muscle and gender, age, or elapsed time since death. Conclusion This is the first longitudinal study to show hyperattenuation of striated muscle on postmortem CT images compared with antemortem CT images in the same patients.


Legal Medicine | 2017

Comparison of the cardiothoracic ratio between postmortem and antemortem computed tomography

Hidemi Okuma; Wataru Gonoi; Masanori Ishida; Go Shirota; Shigeaki Kanno; Yukako Shintani; Hiroyuki Abe; Masashi Fukayama; Kuni Ohtomo

As postmortem imaging has gained prominence as a supplement to traditional autopsy, it is important to understand the normal postmortem changes to enable the accurate evaluation of postmortem imaging. No studies have evaluated the postmortem changes in cardiothoracic ratio (CTR) compared with antemortem images in the same subjects. We studied 147 consecutive subjects who underwent antemortem and postmortem CT, and autopsy. Postmortem CT was performed <23h after death and was followed by autopsy. The subjects were divided into three groups: normal heart, old myocardial infarction, and CPR-treated hearts. CTR was compared between antemortem and postmortem CT using paired t tests, which revealed that the CTR was greater on postmortem CT than on antemortem CT in all groups (mean CTR: 0.53±0.06vs. 0.50±0.06, respectively; P<0.01). Sex, age, time elapsed since death, and the causes of death were examined as potential confounding factors for the postmortem changes in CTR, but no significant associations were found. Receiver-operating characteristic (ROC) curves were used to determine CTR values for cardiomegaly, which was defined according to the autopsy weight of the heart. The area under the ROC curve was 0.71 (95% confidence interval 0.63-0.79). The CTR threshold of 0.54 identified cardiomegaly with the greatest accuracy, compared with the general threshold of 0.50. In conclusion, the CT-determined CTR increases after death, irrespective of the hearts condition. We should be cautious of overdiagnosis of cardiomegaly on postmortem CT, and new criteria for interpreting cardiomegaly on postmortem CTR are needed.

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