Masao Yokoyama

Efficacy of primary hormone therapy for localized or locally advanced prostate cancer: results of a 10‐year follow‐up

To evaluate the efficacy of primary hormone therapy for localized or locally advanced prostate cancer, by analysing the 10‐year survival rates for men with localized or locally advanced prostate cancer treated with primary hormone therapy or prostatectomy.

The staining of golgi membranes with Ricinus communis agglutinin-horseradish peroxidase conjugate in mice tissue cells☆

Ricinus communis agglutinin (RCA)-binding sites were visualized by transmission electron microscopy (TEM) in mice kidney, epididymis and other tissue cells, using the horseradish peroxidase (HRP) as a marker. RCA, a galactose-binding lectin, was conjugated covalently with HRP by the periodate method. Positive reaction with RCA was found at the plasma membrane, Golgi apparatus and multivesicular bodies. Control experiments (e.g. omission of the conjugate, addition of lactose to the incubating medium) established the specificity of the reaction. Plasma membrane staining is in agreement with previously published studies. The staining of the Golgi apparatus was for the first time demonstrated in this study. The positive sites were the cisternal surface of the vesicles and of the saccules of the Golgi apparatus. RCA-HRP staining can be used as a new Golgi marker in cytochemistry.

Blood Pressure Changes Following Extracorporeal Shock Wave Lithotripsy for Urolithiasis

Hypertension after extracorporeal shock wave lithotripsy (ESWL) has been a controversial subject. Changes in blood pressure were studied in 262 patients (mean age 47.8 years) 18.6 months after ESWL. According to World Health Organization criteria the number of patients who showed a decrease exceeded those who showed an increase in blood pressure. The patients who have been on antihypertensive therapy showed a significantly greater decrease in blood pressure than those without medication. Of 192 normotensive patients diastolic pressure increased 1.2 mm. Hg and 2 (1.0%) had hypertension 18.4 months after ESWL. Annualized increase in diastolic pressure and new onset of hypertension were calculated to be 0.78 mm. Hg and 0.65%, respectively. Significant elevation of diastolic pressure was noted in the patients who received a larger number of shock waves. Blood pressure should be carefully followed after ESWL especially in patients who have been treated by a greater number of shock waves.

A prospective and randomized study of primary hormonal therapy for patients with localized or locally advanced prostate cancer unsuitable for radical prostatectomy: results of the 5-year follow-up

To evaluate the effect of primary hormonal therapy for patients with localized and locally advanced prostate cancer.

An Electron Microscopic Study of the Human Adrenal Medulla and Pheochromocytoma

Ultrastructural differences between normal adrenal medulla and pheochromocytoma were studied. Medullary cells exhibit almost the same appearance revealing cytoplasm filled with numerous catecholamine

Early results of radical prostatectomy and adjuvant endocrine therapy for prostate cancer with or without preoperative androgen deprivation

Background: The effects of preoperative androgen deprivation were explored in the patients who received radical prostatectomy and subsequent adjuvant endocrine therapy for prostate cancer.

Preoperative Endocrine Therapy for Clinical Stage A2, B, and C Prostate Cancer: An Interim Report on Short-Term Effects

Background Preoperative endocrine therapy has been suggested to improve surgical radicality and/or patient prognosis in prostate cancer.

Familial Testicular Teratoma in 2 Children: Familial Report and Review of the Literature

Familial occurrence of a testicular tumor is rare. We report mature teratomas in 2 first cousins in a consanguineous family. The cases were unique because both tumors were pathologically similar and their onsets were close. Of 34 families with testicular neoplasms reviewed this is the first family composed of 2 affected children with mature teratomas. The analysis of the familial cases showed segregation of twins and a slightly higher incidence of bilateral tumors. The genetic roles are discussed in the etiology of testicular tumor.

Ultrastructural and biochemical study of benign ganglioneuroma

Ultrastructural and biochemical studies were conducted on three ganglioneuromas to elucidate the morphological features in relation to catecholamine synthesis, storage and secretion. Ganglioneuroma tissues show striking ultrastructural similarity to sympathetic ganglion cells and neurons, being composed of mature ganglion cells, unmyelinated nerve bundles, infrequent myelinated nerve bundles and abundant interstitial elements. Distinct Schwann cells with basement membrane envelope both ganglion cells and nerve processes. Various degrees of morphological differentiations among these tumors are observed e.g. neurofilaments, neurotubules, abundant small clear vesicles (500 Å in size) and large cored vesicles (1 000 Å in size). Small cored vesicles (500 Å in size) are scarcely observed. In two of three tumors studied, catecholamines were detected by chemical assay. Urinary catecholamines were variable. Ultrastructurally most of the ganglioneuromas and ganglioneuroblastomas possess distinct Schwann cells, although a wide spectrum of morphologic variations has been reported. Since present study revealed the presence of large cored vesicles and existence of catecholamines in ganglioneuroma, it is suggested that the catecholamines are stored in large cored vesicles in the tumor, although this study and current knowledge on sympathetic tissues could not provide unequivocal evidences.

Radical prostatectomy and adjuvant endocrine therapy for prostate cancer with or without preoperative androgen deprivation: Five-year results.

Background: The effects of preoperative androgen deprivation on the outcomes of prostate cancer patients who received radical prostatectomy and subsequent adjuvant endocrine therapy have not yet been fully evaluated.