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Featured researches published by Masaru Inage.


Tetrahedron Letters | 1981

Chemical synthesis of phosphorylated fundamental structure of lipid a

Masaru Inage; Haruyuki Chaki; Shoichi Kusumoto; Tetsuo Shiba

Abstract 1-α-Monophosphate ( 2 ), 4′-monophosphate ( 3 ), and 1-α, 4′-diphosphate ( 4 ) of 6-0-(2-deoxy-2-tetradecanoylamino-6-0-tetradecanoyl-β-D-glucopyranosyl) -2-deoxy-2-tetradecanoylamino-3, 4-di -0-tetradecanoyl-D-glucopyranose were prepared in order to elucidate the role of phosphate moieties in endotoxic activity of lipid A.


Tetrahedron Letters | 1983

Synthetic approach to lipid A: Preparation of phosphorylated disaccharides containing (R)-3-hydroxyacyl and (R)-3-acyloxyacyl groups

Masaru Inage; Haruyuki Chaki; Masahiro Imoto; Tetsuo Shimamoto; Shoichi Kusumoto; Tetsuo Shiba

Abstract A synthetic route was established to construct the proposed structure of lipid A which consists of β (1–6) glucosamine disaccharide 1,4′-diphosphate O,N-acylated with (R)-3-hydroxy- or (R)-3-acyloxytetradecanoic acid.


Tetrahedron Letters | 1980

Synthesis of lyposaccharide corresponding to fundamental structure of Salmonella-type lipid A

Masaru Inage; Haruyuki Chaki; Shoichi Kusumoto; Tetsuo Shiba

Abstract 6- O -(2-Deoxy-2-myristoylamino-6- O -myristoyl-β-D-glucopyranosyl)-2-deoxy-2-myristoylamino-3,4-di- O -myristoyl-D-glucopyranose ( 2 ) was prepared in a synthetic approach to lipid A which is the active center of bacterial endotoxin.


Archive | 1981

Immunomodulating and Related Biological Activities of Bacterial Cell Walls and Their Components, Enzymatically Prepared or Synthesized

Shozo Kotani; Haruhiko Takada; Masachika Tsujimoto; Tomohiko Ogawa; Keijiro Kato; Takafumi Okunaga; Yoshitaka Ishihara; Akinori Kawasaki; Ichijiro Morisaki; Nagayuki Kono; Tsutomu Shimono; Tetsuo Shiba; Shoichi Kusumoto; Masaru Inage; Kazuhiro Harada; Toshiyuki Kitaura; Seisaburo Kano; Shinya Inai; Kazuyoshi Nagai; Misako Matsumoto; Takashi Kubo; Masahiko Kato; Zenichi Tada; Kanae Yokogawa; Shigeo Kawata; Atsuo Inoue

In 1959, we isolated the cell walls of tubercle bacilli (BCG) which have long been known to have a strong immunoadjuvant activity, especially in the stimulation of cell-mediated immune responses, and elucidated the chemical and immunological properties of this cell wall fraction (32, 31). The most remarkable finding on the chemical composition of this subcellular fraction was that various lipids, especially ethanol-ether insoluble but chloroform-soluble lipids and bound lipids, which characterized tubercle bacilli were almost exclusively localized in their cell walls. It was also demonstrated that the cell walls were the most active fraction of subcellular components isolated from sonicated BCG cells, in inducing tuberculin hypersensitivity in guinea pigs and that the cell walls were involved in the development of an acquired cell-mediated resistance of mice to tuberculous infection.


Tetrahedron Letters | 1980

Synthesis of 4-o-(N-acetyl-β-D-glucosaminyl)-6-o-acyl-N-acetylmuramyl-L-alanyl-D-isoglutamine

Masaru Inage; Masahiro Imoto; Yoshikazu Kambayashi; Shoichi Kusumoto; Tetsuo Shiba

Abstract Long-chain acyl derivatives of the disaccharide dipeptide, which is a common building unit of bacterial cell walls, were synthesized in order to test their immunostimulating activity.


Infection and Immunity | 1981

Stimulation of nonspecific resistance to infection induced by 6-O-acyl muramyl dipeptide analogs in mice.

Kensuke Matsumoto; Hidemasa Ogawa; T Kusama; O Nagase; N Sawaki; Masaru Inage; Shoichi Kusumoto; Tetsuo Shiba; Ichiro Azuma


Infection and Immunity | 1979

Macrophage activation by bacterial cell walls and related synthetic compounds.

Haruhiko Takada; Masachika Tsujimoto; Keijiro Kato; Shozo Kotani; Shoichi Kusumoto; Masaru Inage; Tetsuo Shiba; Ikuya Yano; Shigeo Kawata; Kanae Yokogawa


Tetrahedron Letters | 1978

Synthesis of long chain fatty acid esters of N-acetylmuramyl-L-alanyl-D-isoglutamine in relation to antitumor activity☆

Shoichi Kusumoto; Masaru Inage; Tetsuo Shiba; Ichiro Azuma; Yuichi Yamamura


Chemistry Letters | 1982

A convenient preparative method of carbohydrate phosphates with butyllithium and phosphorochloridate.

Masaru Inage; Haruyuki Chaki; Shoichi Kusumoto; Tetsuo Shiba


Infection and Immunity | 1979

Mitogenic Effects of Bacterial Cell Walls, Their Fragments, and Related Synthetic Compounds on Thymocytes and Splenocytes of Guinea Pigs

Haruhiko Takada; Masachika Tsujimoto; Shozo Kotani; Shoichi Kusumoto; Masaru Inage; Tetsuo Shiba; Shigeki Nagao; Ikuya Yano; Shigeo Kawata; Kanae Yokogawa

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