Masashi Horimoto

Red Blood Cell Deformability in Renal Failure

Red blood cell deformability was measured in 74 cases of renal failure and diabetic nephropathy by means of a modified nuclepore membrane filter method. Low red blood cell deformability was observed in a certain proportion of the patients. In cases of renal failure only weak correlation was found between reduced red blood cell deformability and BUN as well as between reduced red blood cell deformability and creatinine level, while simultaneous changes in these variable were observed in several patients. The reduction in red blood cell deformability in cases of diabetic nephropathy slightly exceeded that in cases of renal failure and correlated with an increment in HbA1c content. The effects of uremic toxins were unclear in in vitro tests. The red blood cell deformability was impaired in nephrectomized rabbits.

Evolution of left ventricular involvement in arrhythmogenic right ventricular cardiomyopathy

Left ventricular (LV) involvement in arrhythmogenic right ventricular cardiomyopathy (ARVC) is fairly well known, but the evolution of LV involvement during long-term follow-up has not been well documented. We describe such evolution in a patient followed for 9 years. Evolution was confirmed by a progressive perfusion defect of the LV wall in myocardial scintigrams and by the development of LV asynergy with ventricular aneurysm formation in left ventriculograms. As the right ventricle progressively enlarged, we concluded that ARVC is a diffuse and progressive myocardial disease that affects both ventricles.

Multiple coronary thromboemboli complicating valvular heart disease and atrial fibrillation.

T, and the Coinvestigators of the National Heart, Lung, and Blood Institutes Percutaneous Transluminal Coronary Angioplasty Registry. One-year follow-up results of the 1985-86 National Heart, Lung, and Blood Institutes Percutaneous Transluminal Coronary Angioplasty Registry. Circulation 1989;80:421-8. 6. Thomas MR, Wainwright RJ. Use of an intracoronary stent to control intrapericardial bleeding during artery rupture complicating coronary angioplasty. Cathet Cardiovasc Diaga 1993;30:169-72.

Blood flow velocity in pulmonary microvessels of bullfrog

Flow velocity in the pulmonary microvessels of the exposed lung of bullfrogs was measured by means of a laser Doppler microscope of an oblique backward mode, together with a signal-analyzing system having a time sharing circuit triggered by the R-wave of the ECG. By these means, measurements of the changes of flow velocity contour in the cardiac cycle were made. Flow velocity was clearly pulsatile in response to cardiac cycles in all microvessels including capillaries. Flow velocities in the arteriole and venule consistently decreased for a short period after the R-wave (84 +/- 33 msec (mean +/- SD) in the arteriole and 130 +/- 31 msec in the venule, respectively) and rapidly increased up to a maximicronm value. The mean flow velocities in arterioles (diameter 50 +/- 17 micron) and venules (39 +/- 9 micronm) were 2.29 +/- 0.32 and 2.30 +/- 0.27 mm/sec. The amplitudes of pulsatile flow in these vessels were 0.83 +/- 0.31 and 0.63 +/- 0.16 mm/sec, respectively. In the capillary the times from the R-wave to the minimicronm and maximum values were variable. In some cases the velocity gradually increased without first decreasing and the increase sharply accelerated a certain time after the R-wave. The mean velocity in the pulmonary capillary and the amplitude of the pulsatile flow ere 1.78 +/- 0.31 and 0.37 +/- 0.12 mm/sec, resepctively. The ratios of the pulsatile amplitude to the mean velocity in the pulmonary capillary, venule and arteriole averaged 0.21, and 0.36, respectively.

Reduced deformability of erythrocytes exposed to hypercapnia.

The effect of hypercapnia on the deformability of erythrocytes was studied by means of a nuclepore membrane filter method. A decrement of the deformability by 20–40% was observed when

Initial adjustment of cardiac output in response to onset of exercise in patients with chronic pacemaking as studied by the measurement of pulmonary blood flow

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Laser Doppler microscope in an oblique-backward mode and pulsatile blood flow velocity in pulmonary arteriole

was increased from 50 mm Hg to 200 mm Hg, accompanied with an increment of 5% in hematocrit value.

Bilateral internal carotid artery disease secondary to cervical radiation. A case report.

The average transit time of single red blood cells through a nuclepore membrane filter (pore diameter and length, 5 μm and 10 μm, respectively) was measured using an improved method and was shown to be an index of deformability. An increased passage time, indicating reduced deformability, was observed in renal failure.