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Publication
Featured researches published by Masashi Tagawa.
Pathology International | 1992
Masanori Murakoshi; Rie Inada; Masashi Tagawa; Masao Makino; Minoru Suzuki; Mamoru Mieda; Seijiroh Honma; Yutaka Takezawa; Hidetoshi Yamanaka
The effect of a synthetic steroidal anti‐androgen, TZP‐4238, on spontaneous benign prostatic hyperplasia (BPH) in dogs was investigated. Old male beagle dogs (5–9 years old) were divided into three experimental groups. Group 1 consisted of BPH controls. Groups 2 and 3 received TZP‐4238 0.1 mg/kg/day and chlormadinone acetate (CMA) 0.3 mg/kg/day P.o., respectively, for 5 months. In group 1, glandular hyperplasia of the prostate was clearly detected. In contrast, TZP‐4238 (Group 2) or CMA (Group 3) produced marked atrophy of the glandular epithelium. In addition, a histopathological study showed that TZP‐4238 or CMA medication for 5 months exerted no effect on the testes and the pituitary luteinizing hormone (LH) cells. Therefore, it is suggested that TZP 4238 (0.1 mg/kg) or CMA (0.3 mg/kg) causes regression of spontaneous canine BPH without any histopathological effects on the testes and pituitary LH cells. However, slightly decreased serum testosterone levels were found in TZP 4238 treated animals, due apparently to a direct and/or indirect effect on the testes. Thus, it is suggested that a marginal antigonadotrophic effect cannot be excluded. It is concluded that TZP‐4238 is a potent anti‐androgen for the treatment of spontaneous canine BPH, without any negative influence on the function of the testes and the pituitary LH cells. Acta Pathol Jpn 42: 151–157, 1992.
Journal of Toxicological Sciences | 1999
Masanori Murakoshi; Rie Ikada; Masashi Tagawa
Journal of Toxicologic Pathology | 1993
Masanori Murakoshi; Rie Inada; Masashi Tagawa; Minoru Suzuki; Atsushi Mizokami; Keiichi Watanabe
The Tokai journal of experimental and clinical medicine | 1992
Masanori Murakoshi; Masashi Tagawa; Rie Inada; Minoru Suzuki
Journal of Toxicological Sciences | 2000
Masanori Murakoshi; Masashi Tagawa; Rie Ikeda
Acta Histochemica Et Cytochemica | 2000
Masanori Murakoshi; Masashi Tagawa; Rie Ikeda; Takaharu Nakayama; Kazunori Ishimura
Endocrine Journal | 1993
Masanori Murakoshi; Masashi Tagawa; Rie Inada; Minoru Suzuki; Atsushi Mizokami; Keiichi Watanabe
The Tokai journal of experimental and clinical medicine | 2000
Masanori Murakoshi; Masashi Tagawa; Rie Ikeda
Journal of Toxicological Sciences | 1999
Masanori Murakoshi; Rie Ikeda; Masashi Tagawa
The Tokai journal of experimental and clinical medicine | 1997
Masanori Murakoshi; Rie Ikeda; Masashi Tagawa; Minoru Suzuki; Susumu Takekoshi; Keiichi Watanabe