Masashi Yanase

Practical synthesis of (R)-γ-amino-β-hydroxybutanoic acid (GABOB) from (R)-epichlorohydrin

Abstract (R)-Epichlorohydrin has efficiently been converted to the hypotensive and antiepileptic compound, (R)-γ-amino-β-hydroxybutanoic acid (GABOB), in six steps in 57% overall yield.

Enantiodivergent synthesis of both enantiomers of ibuprofen from (2S,3S)-3-phenylglycidol

Enantiodivergent synthesis of both enantiomers of ibuprofen, a potent orally active anti-inflammatory agnen, has been first established using (2S,3S)-3-phenylglycidol as a common starting material

Oxidation of alcohols using dimethyl sulfoxide and trichloromethyl chloroformate

Abstract Treatment of structurally diverse alcohols with dimethyl sulfoxide in the presence of trichloromethyl chloroformate (phosgene dimer) and triethylamine efficiently afforded the corresponding aldehydes or ketones in excellent yields.

A concise route to (S)-phenylalanine from (R)-epichlorohydrin

A concise route to (S)-phenylalanine has been established starting from (R)-epichlorohydrin

Enantiodivergent route to the aromatic bisabolane sesquiterpenes by regio- and stereo-controlled epoxide opening

An enantiodivergent route to aromatic bisabolane sesquiterpenes from a single chiral precursor has been established by employing regio- and stereo-controlled epoxide opening as the key step.