Masato Mochiki

Results of Multimodality Therapy for Squamous Cell Carcinoma of Maxillary Sinus

A wide variety of modalities, including surgery, radiation therapy, and chemotherapy, alone or in combination, have been used for the treatment of squamous cell carcinoma (SCC) of the maxillary sinus to obtain better local control and maintain functions. However, there is still much controversy with regard to the optimum treatment.

Analysis of Prognostic Factors of Nasopharyngeal Carcinoma: Impact of in Situ Hybridization for Epstein-Barr Virus Encoded Small RNA 1

OBJECTIVES: To evaluate the impact of clinical, histopathological, and molecular biological parameters on the prognosis of nasopharyngeal carcinoma (NPC). STUDY DESIGN AND SETTING: The clinical records of 48 patients with a diagnosis of NPC were retrospectively reviewed. In situ hybridization for Epstein-Barr virus encoded small RNA 1 (EBER-ISH) was applied for 30 paraffin-embedded specimens available. Prognostic factors of NPC were meticulously analyzed. RESULTS: The EBER-ISH signal was shown to be highly significant as a favorable prognostic factor (P = 0.007). Although EBV was more commonly associated with Type III NPC, EBER-ISH-positive Type I-II NPC had also significantly better survival rate than EBER-ISH-negative Type I-II NPC (P = 0.036). CONCLUSIONS: In addition to the WHO histopathological grade, the 1997 UICC staging, nodal status, and distant metastasis at presentation, the EBER-ISH signal was shown to be significant as a prognostic factor. SIGNIFICANCE: This is the first report to describe the EBER-ISH as an independent prognostic factor of NPC regardless of histopathology.

Prognostic factors for hypopharyngeal cancer: a univariate and multivariate study of 142 cases

Conclusions. Reduction of distant metastases is essential for better survival. Effective adjuvant chemotherapy should be developed for patients with advanced primary disease (T>2) as well as for patients with advanced nodal status (N>0 or PLN>2). Objectives. The aim of this study was to identify prognostic factors for hypopharyngeal cancer. Patients and methods. In all, 142 previously untreated patients were analyzed retrospectively; 75% of the cases were stage III or IV. Surgical resection was administered as primary treatment to 116 of the patients (82%), while 26 patients (18%) underwent primary radiotherapy. Results. The cause-specific 5-year actuarial survival was 46.3%. Distant metastases were the most frequent (23%) cause of failure, followed by local recurrence (15%), and regional recurrence (13%). Coxs regression analysis showed that the significant factors affecting cause-specific survival were N classification, T classification, number of pathological lymph node metastases (PLN), lymphatic invasion, and positive surgical margin. Similarly, T classification and PLN affected distant metastases.

Fibromatosis of the infratemporal fossa extending to the parapharyngeal space accompanied by trismus.

Fibromatosis is a tumor of fibroblastic origin that may arise in any musculoaponeurotic structure. Although fibromatosis is histologically benign, it has a tendency to invade surrounding tissues and often recur locally after treatment. A 34-year-old female patient was presented with pain in the left buccal region, left loss of visual acuity, and trismus. Computed tomographic scans revealed a large mass in the infratemporal fossa and parapharyngeal space. An open biopsy was performed and the pathological diagnosis was a fibromatosis. Surgical treatment for her trismus was performed simultaneously.