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Dive into the research topics where Masato Watarai is active.

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Featured researches published by Masato Watarai.


Hypertension | 2012

Comparison Between Valsartan and Amlodipine Regarding Cardiovascular Morbidity and Mortality in Hypertensive Patients With Glucose Intolerance: NAGOYA HEART Study

Takashi Muramatsu; Kunihiro Matsushita; Kentaro Yamashita; Takahisa Kondo; Kengo Maeda; Satoshi Shintani; Satoshi Ichimiya; Miyoshi Ohno; Takahito Sone; Nobuo Ikeda; Masato Watarai; Toyoaki Murohara

It has not been fully examined whether angiotensin II receptor blocker is superior to calcium channel blocker to reduce cardiovascular events in hypertensive patients with glucose intolerance. A prospective, open-labeled, randomized, controlled trial was conducted for Japanese hypertensive patients with type 2 diabetes mellitus or impaired glucose tolerance. A total of 1150 patients (women: 34%; mean age: 63 years; diabetes mellitus: 82%) were randomly assigned to receive either valsartan- or amlodipine-based antihypertensive treatment. Primary outcome was a composite of acute myocardial infarction, stroke, coronary revascularization, admission attributed to heart failure, or sudden cardiac death. Blood pressure was 145/82 and 144/81 mm Hg, and glycosylated hemoglobin was 7.0% and 6.9% at baseline in the valsartan group and the amlodipine group, respectively. Both of them were equally controlled between the 2 groups during the study. The median follow-up period was 3.2 years, and primary outcome had occurred in 54 patients in the valsartan group and 56 in the amlodipine group (hazard ratio: 0.97 [95% CI: 0.66–1.40]; P=0.85). Patients in the valsartan group had a significantly lower incidence of heart failure than in the amlodipine group (hazard ratio: 0.20 [95% CI: 0.06–0.69]; P=0.01). Other components and all-cause mortality were not significantly different between the 2 groups. Composite cardiovascular outcomes were comparable between the valsartan- and amlodipine-based treatments in Japanese hypertensive patients with glucose intolerance. Admission because of heart failure was significantly less in the valsartan group.


Journal of Cardiology | 2012

Atorvastatin 10 mg plus ezetimibe 10 mg compared with atorvastatin 20 mg: Impact on the lipid profile in Japanese patients with abnormal glucose tolerance and coronary artery disease

Yusuke Uemura; Masato Watarai; Hideki Ishii; Masayoshi Koyasu; Kenji Takemoto; Daiji Yoshikawa; Rei Shibata; Tatsuaki Matsubara; Toyoaki Murohara

BACKGROUND Oxidized low-density lipoprotein (LDL) cholesterol is a sensitive lipid marker for predicting atherosclerosis. Ezetimibe and statins are reported to decrease both LDL cholesterol and oxidized LDL cholesterol. This prospective randomized open-label crossover study compared combination therapy with atorvastatin plus ezetimibe versus high-dose atorvastatin monotherapy. Changes in serum lipids, including malondialdehyde-modified LDL (MDA-LDL) as a representative form of oxidized LDL cholesterol, and glucose metabolism were assessed. METHODS AND RESULTS The subjects were 39 Japanese patients with coronary artery disease and type 2 diabetes or impaired glucose tolerance who were taking 10 mg/day of atorvastatin (30 men and 9 women with a mean age of 67.8 years). They were randomized to a group that first received add-on ezetimibe (10 mg/day) or a group that first received atorvastatin monotherapy at a higher dose of 20 mg/day. Both treatments were given for 12 weeks each in a crossover fashion. Add-on ezetimibe significantly decreased MDA-LDL (109.0 ± 31.9 mg/dl to 87.7 ± 29.4 mg/dl, p=0.0009), while up-titration of atorvastatin did not. The decrease with add-on ezetimibe was significantly greater than with up-titration of atorvastatin (p=0.0006). Total cholesterol and LDL cholesterol were significantly decreased by both treatments, but the percent reduction with add-on ezetimibe was significantly greater (p<0.05). High-density lipoprotein cholesterol was significantly increased by both treatments and there was no significant difference between them. The apolipoprotein B/apolipoprotein A-I ratio and remnant-like particle cholesterol were only significantly decreased by add-on ezetimibe. Both treatments caused similar elevation of hemoglobin A(1c). CONCLUSION In Japanese patients with type 2 diabetes or impaired glucose tolerance and coronary artery disease, adding ezetimibe (10 mg/day) to atorvastatin (10 mg/day) significantly improved the lipid profile compared with atorvastatin monotherapy at 20 mg/day.


Journal of Cardiology | 2016

Elevation of red blood cell distribution width during hospitalization predicts mortality in patients with acute decompensated heart failure

Yusuke Uemura; Rei Shibata; Kenji Takemoto; Tomohiro Uchikawa; Masayoshi Koyasu; Hiroki Watanabe; Takayuki Mitsuda; Ayako Miura; Ryo Imai; Masato Watarai; Toyoaki Murohara

BACKGROUND Increased red blood cell distribution width (RDW) is associated with adverse outcomes in heart failure. In the present study, we assessed the association between changes in RDW values during hospitalization and long-term prognosis in patients with acute decompensated heart failure (ADHF). METHODS We measured the RDW value in 229 consecutive patients with ADHF. Blood samples were obtained at the time of hospital admission and at discharge. Changes in RDW were calculated as the mean difference between RDW values on admission and those at the time of hospital discharge. RESULTS Patients were followed up for a median of 692 days. A Kaplan-Meier survival analysis demonstrated that patients whose RDW levels increased during hospitalization had significantly higher all-cause and cardiac-based mortality following heart failure than did patients whose RDW levels decreased during hospitalization. A multivariate Cox regression analysis revealed that change in RDW values during hospitalization, but not the values of RDW and hemoglobin on admission, was independently correlated with all-cause and cardiac-based mortality after adjusting for other risk factors in patients with ADHF. CONCLUSIONS These data document that the change in RDW values during hospitalization independently predicts poor outcomes in patients with ADHF. Continuous follow-up of RDW values could provide useful information for long-term prognosis after heart failure.


Coronary Artery Disease | 2011

Mild stenosis makes prognosis of vasospastic angina worse.

Fumimaro Takatsu; Masato Watarai

ObjectiveSeveral studies have shown that significant coronary narrowing makes the prognosis of vasospastic angina pectoris (VAP) worse. However, the effects of various factors on the prognosis of patients without significant arterial narrowing have not yet been shown. Methods and resultsWe investigated 1248 consecutive patients with VAP who had no coronary stenosis of more than or equal to 50%. The mean follow-up was 11.7±6.8 years. Ninety-one patients (7.3%) developed unstable angina, acute myocardial infarction, or effort angina with new coronary narrowings. Thirty patients (2.4%) died suddenly. Multivariate analysis showed that the presence of coronary stenosis, even if trivial, made the prognosis worse (P=0.027; odds ratio, 1.66; 95% confidence interval, 1.06–2.61). In addition, unusually, female patients had a better prognosis than male patients (P=0.007; odds ratio, 0.35; 95% confidence interval, 0.16–0.75). Other factors, such as hyperlipemia, diabetes, and hypertension did not affect the prognosis. ConclusionIn patients with VAP, the presence of coronary narrowing, even if mild, was associated with worse prognosis.


Circulation | 2017

Safety and Efficacy of Long-Term Use of Tolvaptan in Patients With Heart Failure and Chronic Kidney Disease

Yusuke Uemura; Rei Shibata; Kenji Takemoto; Tomohiro Uchikawa; Masayoshi Koyasu; Shinji Ishikawa; Ryo Imai; Yuta Ozaki; Takashi Watanabe; Tsubasa Teraoka; Masato Watarai; Toyoaki Murohara

BACKGROUND We assessed the long-term safety and efficacy of tolvaptan in 102 patients with heart failure (HF) and chronic kidney disease (CKD). Median follow-up duration was 1.6 years (1.0-4.4 years).Methods and Results:One patient discontinued tolvaptan because of hypernatremia. There were no changes in renal function or electrolytes during the 1-year follow-up. The cardiac-related death-free or HF-related hospitalization-free survival rate was significantly higher in patients receiving tolvaptan than in propensity score-matched patients who did not receive tolvaptan. CONCLUSIONS In patients with HF and CKD, long-term administration of tolvaptan was well-tolerated, relatively safe and effective, suggesting its utility for long-term management of these conditions.


Internal Medicine | 2017

Early Spontaneous Remission of Intramyocardial Dissecting Hematoma

Ayako Miura; Yusuke Uemura; Kenji Takemoto; Tomohiro Uchikawa; Masayoshi Koyasu; Shinji Ishikawa; Takayuki Mitsuda; Ryo Imai; Satoshi Iwamiya; Yuta Ozaki; Takashi Watanabe; Masato Watarai; Hideki Ishii; Toyoaki Murohara

Intramyocardial dissecting hematoma is a rare but potentially fatal complication of myocardial infarction. The decision to adopt a surgical or conservative strategy may depend on the clinical and hemodynamic stability of patients. Regardless, the precise and temporal assessment of the structure of hematoma is imperative. We herein report the first case of a patient with early spontaneous remission of intramyocardial dissecting hematoma successfully managed by a conservative approach with multimodality imaging.


Journal of Arrhythmia | 2018

Comparison of uninterrupted anticoagulation with dabigatran etexilate or warfarin in the periprocedural period for atrial fibrillation catheter ablation: Results of the Japanese subgroup of the RE‐CIRCUIT trial

Yukihiko Yoshida; Masato Watarai; Kenshi Fujii; Wataru Shimizu; Kazuhiro Satomi; Yasuya Inden; Yoshimasa Murakami; Masato Murakami; Atsushi Iwasa; Masaomi Kimura; Nobuko Yamada; Tomofumi Nakagawa; Matias Nordaby; Ken Okumura

There are limited data on uninterrupted anticoagulation with direct oral anticoagulants during catheter ablation for atrial fibrillation (AF), particularly in Japan. We planned a subgroup analysis of the RE‐CIRCUIT study, comparing the use of uninterrupted dabigatran therapy with warfarin therapy during catheter ablation among the Japanese subgroup and with that in the total population.


European Heart Journal | 2004

Genetic risk and gene–environment interaction in coronary artery spasm in Japanese men and women

Yosuke Murase; Yoshiji Yamada; Akihiro Hirashiki; Sahoko Ichihara; Hirofumi Kanda; Masato Watarai; Fumimaro Takatsu; Toyoaki Murohara; Mitsuhiro Yokota


Circulation | 2004

Insulin Resistance and Fasting Hyperinsulinemia Are Risk Factors for New Cardiovascular Events in Patients With Prior Coronary Artery Disease and Normal Glucose Tolerance

Masanobu Yanase; Fumimaro Takatsu; Takayuki Tagawa; Tomoko S. Kato; Kosuke Arai; Masayoshi Koyasu; Hideki Horibe; Shigeru Nomoto; Kenji Takemoto; Seiji Shimizu; Masato Watarai


Clinical Therapeutics | 2010

Impact of acarbose on carotid intima-media thickness in patients with newly diagnosed impaired glucose tolerance or mild type 2 diabetes mellitus: A one-year, prospective, randomized, open-label, parallel-group study in Japanese adults with established coronary artery disease

Masayoshi Koyasu; Hideki Ishii; Masato Watarai; Kenji Takemoto; Yasuya Inden; Kyosuke Takeshita; Tetsuya Amano; Daiji Yoshikawa; Tatsuaki Matsubara; Toyoaki Murohara

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