Masatoshi Yasuda
Kyoto University
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Publication
Featured researches published by Masatoshi Yasuda.
International Journal of Pharmaceutics | 2014
Takehiko Horio; Masatoshi Yasuda; Shuji Matsusaka
Powder flowability of microcrystalline cellulose particles having different particle shapes, whose aspect ratios ranged from 1.8 to 6.4, was measured using the vibration shear tube method. Particles lubricated with magnesium stearate were also investigated in order to evaluate the effect of surface modification on powder flowability. Particles were discharged through a narrow gap between a vibrating tube edge and a flat bottom surface, where each particle experienced high shear forces, thus, overcoming adhesion and friction forces. Vibration amplitude was increased at a constant rate during measurement and the masses of the discharged particles were measured at consistent time intervals. Flowability profiles, i.e., the relationships between the mass flow rates of the discharged particles and their vibration accelerations, were obtained from these measurements. Critical vibration accelerations and characteristic mass flow rates were then determined from flowability profiles in order to evaluate static and dynamic friction properties. The results were compared with those obtained using conventional methods. It was found that angle of repose and compressibility were related to static and dynamic friction properties. Furthermore, it was found that particle aspect ratio more significantly affects powder flowability than does lubrication with magnesium stearate.
Scientific Reports | 2013
Shuji Matsusaka; Murino Kobayakawa; Megumi Mizutani; Mohd Imran; Masatoshi Yasuda
We demonstrate that a vibration-induced air inflow can cause vigorous bubbling in a bed of fine particles and report the mechanism by which this phenomenon occurs. When convective flow occurs in a powder bed as a result of vibrations, the upper powder layer with a high void ratio moves downward and is compressed. This process forces the air in the powder layer out, which leads to the formation of bubbles that rise and eventually burst at the top surface of the powder bed. A negative pressure is created below the rising bubbles. A narrow opening at the bottom allows the outside air to flow into the powder bed, which produces a vigorously bubbling fluidized bed that does not require the use of an external air supply system.
Drug Development and Industrial Pharmacy | 2013
Takehiko Horio; Masatoshi Yasuda; Shuji Matsusaka
Background: The evaluation of lubricity or flowability of pharmaceutical powders is important for consistent production and quality control of drug products. However, there have been only a few studies on quantitative measurements of the properties of lubricated powders. Method: Magnesium stearate (MgSt) and sodium stearyl fumarate (SSF) were used as lubricants. Lubricated powders were prepared by adding lubricants to spray-dried lactose under different conditions. To evaluate flowability, the vibrating tube method was used. In this method, the vibration amplitude of the tube is increased at a constant rate, and the mass of the powder discharged from the tube is recorded. Flowability profiles, i.e. the relationships between the mass flow rate and vibration acceleration, were obtained experimentally. To characterize static and dynamic friction properties of powders, critical vibration acceleration required to make powder particles flow and the average mass flow rate were determined. Results: Addition of 0.5% MgSt was sufficient for the reduction of static friction between particles. Blending time of the lubricants had little effect on the average mass flow rate of lubricated powders. On the other hand, addition of SSF resulted in an increase in static friction at the beginning of blending, and after a certain blending time, flowability improved. The combination of MgSt and SSF improved both static and dynamic friction properties irrespective of the blending time. Conclusion: The vibrating tube method can be used to evaluate the flowability properties of lubricated powders, and the experimental results provide useful information on the production of pharmaceutical solid dosage forms.
POWDERS AND GRAINS 2013: Proceedings of the 7th International Conference on Micromechanics of Granular Media | 2013
Murino Kobayakawa; Masatoshi Yasuda; Shuji Matsusaka
The movement of particles in the range from 0.5 to 500 μm in mass median diameter on a two-dimensional vibrating plate is observed through a high-speed digital camera with a zoom lens. The results show that larger particles saltate higher, while smaller particles easily agglomerate and slightly saltate because of the low restitution of their loosely packed structure. The salation heights are in good agreement with the results calculated by a model based on gravity, adhesion, drag force, and restitution.
Particle & Particle Systems Characterization | 2012
Imran M. Zainuddin; Masatoshi Yasuda; Takehiko Horio; Shuji Matsusaka
Advanced Powder Technology | 2015
Megumi Mizutani; Masatoshi Yasuda; Shuji Matsusaka
Advanced Powder Technology | 2011
Katsunori Ishii; Masahiro Suzuki; Tomoomi Segawa; Yoshiyuki Kihara; Masatoshi Yasuda; Shuji Matsusaka
Journal of Chemical Engineering of Japan | 2009
Katsunori Ishii; Masahiro Suzuki; Takuma Yamamoto; Yoshiyuki Kihara; Yoshiyuki Kato; Tsutomu Kurita; Katsunobu Yoshimoto; Masatoshi Yasuda; Shuji Matsusaka
Archive | 2006
Shuji Matsusaka; Hiroaki Masuda; Yanbin Jiang; Masatoshi Yasuda
Advanced Powder Technology | 2015
Shuji Matsusaka; Dan Wei; Masatoshi Yasuda; Shuji Sasabe