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Featured researches published by Masayo Sato.
Nephrology | 2018
Keisuke Sato; Shiho Makabe; Yuko Iwabuchi; Kaori Kojima; Masayo Sato; Hiroshi Kataoka; Takahito Moriyama; Sekiko Taneda; Ken Tsuchiya; Kosaku Nitta; Toshio Mochizuki
We report a case of glomerulonephritis with monoclonal immunoglobulin (Ig) A deposits as a form of monoclonal gammopathy of renal significance (MGRS) caused by monoclonal immunoglobulins without blood disorders in a 41‐year‐old woman. She developed lower leg oedema and was hospitalized because of nephrotic syndrome. Serum and urine were negative for M protein, and the free light chain κ/λ ratio was within the normal range. Renal histopathological findings included mesangial proliferation, endocapillary cell proliferation, and a double‐contour appearance of the capillary walls. Immunofluorescent staining indicated IgA and C3 deposits on the mesangium and capillary walls. Only λ chain and IgA1 deposits were noted. Fine granular sub‐endothelial deposits with no specific structure were observed under electron microscopy. The patient was diagnosed with IgA–proliferative glomerulonephritis with monoclonal immunoglobulin deposits (IgA‐PGNMID). The patient had decreased urine protein and sediment erythrocytes after she underwent two rounds of steroid pulse therapy and oral steroid therapy, but proteinuria and haematuria still remained. Four months later, the patient was administered 50 mg/day cyclosporine (CsA), and proteinuria and haematuria dramatically decreased. Only a few case reports have been published on IgA‐PGNMID. This case is rare in that the patient achieved successful treatment using a combination of steroids and CsA.
Nephrology | 2015
Keiko Kawaguchi; Kunio Kawanishi; Masayo Sato; Mitsuyo Itabashi; Akiko Fujii; Yukiko Kanetsuna; Shouhei Huchinoue; Ryuji Ohashi; Junki Koike; Kazuho Honda; Yoji Nagashima; Kosaku Nitta
Atypical hemolytic uremic syndrome (aHUS) in allograft kidney transplantation is caused by various factors including rejection, infection, and immunosuppressive drugs. We present a case of a 32 year old woman with aHUS four years after an ABO‐incompatible kidney transplantation from a living relative. The primary cause of end‐stage renal disease was unknown; however, IgA nephropathy (IgAN) was suspected from her clinical course. She underwent pre‐emptive kidney transplantation from her 60 year old mother. The allograft preserved good renal function [serum creatinine (sCr) level 110–130 μmol/L] until a sudden attack of abdominal pain four years after transplant, with acute renal failure (sCr level, 385.3 μmol/L), decreasing platelet count, and hemolytic anemia with schizocytes. On allograft biopsy, there was thrombotic microangiopathy in the glomeruli, with a cellular crescent formation and mesangial IgA and C3 deposition. Microvascular inflammation, such as glomerulitis, peritubular capillaritis, and arteriole endarteritis were also detected. A disintegrin‐like and metalloproteinase with thrombospondin type 1 motifs 13 (ADAMTS13) did not decrease and Shiga toxin was not detected. Donor‐specific antibodies or autoantibodies, including anti‐neutrophil cytoplasmic antibody and anti‐glomerular basement membrane (anti‐GBM) antibody, were negative. The patient was diagnosed with aHUS and received three sessions of plasmapheresis and methylprednisolone pulse therapy, followed by oral methylprednisolone (0.25–0.5 mg/kg) instead of tacrolimus. She temporarily required hemodialysis (sCr level, 658.3 μmol/L). Thereafter, her sCr level improved to 284.5 μmol/L without dialysis therapy. This case is clinically considered as aHUS after kidney transplantation, associated with various factors, including rejection, glomerulonephritis, and toxicity from drugs such as tacrolimus.
Internal Medicine | 2019
Kentaro Watanabe; Teruhiro Fujii; Shiho Makabe; Haruno Nakajima; Masayo Sato; Hiroshi Kataoka; Ken Tsuchiya; Kosaku Nitta; Toshio Mochizuki
We encountered a patient with autosomal dominant polycystic kidney disease (ADPKD) complicated with emphysematous polycystic renal infection (EPRI). A 44-year-old woman visited our hospital for a fever, appetite loss, and gross hematuria. Because the patient was suffering from end-stage renal disease (ESRD), she was immediately hospitalized for hemodialysis. Multiple emphysematous infected cysts were noted in the right kidney, and antibiotic therapy and three rounds of cystic drainage were performed. However, the patient did not respond to treatment. Therefore, laparoscopic right nephrectomy was performed. ADPKD with comorbid EPRI is unresponsive to conservative treatment, and we believe that nephrectomy should be considered.
Clinical and Experimental Nephrology | 2012
Hiroshi Kataoka; Mamiko Ohara; Kaori Shibui; Masayo Sato; Tomo Suzuki; Nobuyuki Amemiya; Yoshihiko Watanabe; Kazuho Honda; Takahiro Mochizuki; Kosaku Nitta
Journal of Nephrology | 2015
Takahito Moriyama; Mitsuyo Itabashi; Takashi Takei; Hiroshi Kataoka; Masayo Sato; Ari Shimizu; Yuko Iwabuchi; Miki Nishida; Keiko Uchida; Kosaku Nitta
Internal Medicine | 2012
Masayo Sato; Tetsuya Ogawa; Himiko Sugimoto; Kuniaki Otsuka; Kosaku Nitta
International Urology and Nephrology | 2014
Tetsuya Ogawa; Himiko Shimizu; Ai Kyono; Masayo Sato; Tetsuri Yamashita; Kuniaki Otsuka; Kosaku Nitta
Clinical and Experimental Nephrology | 2012
Tetsuya Ogawa; Ai Kyono; Masayo Sato; Himiko Sugimoto; Kuniaki Otsuka; Kosaku Nitta
International Urology and Nephrology | 2010
Masayo Sato; Yuko Iwasa; Shigeru Otsubo; Naoki Kimata; Takashi Takei; Naoko Miwa; Takashi Akiba; Kosaku Nitta
Clinical and Experimental Nephrology | 2013
Masayo Sato; Tetsuya Ogawa; Kuniaki Otsuka; Yoshitaka Ando; Kosaku Nitta