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Dive into the research topics where Masayuki Oya is active.

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Featured researches published by Masayuki Oya.


European Journal of Pharmacology | 1979

Potentiating mechanism of bradykinin action on smooth muscle by sulfhydryl compounds.

Tadashi Iso; Kazuo Nishimura; Masayuki Oya; Jun-Ichi Iwao

(4R)-3-[(2S)-3-Mercapto-2-methylpropanoyl]-4-thiazolidinecarboxylic acid (YS-980), a potent angiotensin I (AI) converting enzyme inhibitor, inhibited the contractile response of isolated guinea-pig ileum to AI but not to AII, while it potentiated the response to bradykinin. Other sulfhydryl compuonds also produced inhibition of AI action, and the effects were closely correlated with their potentiating activities against bradykinin action. These results suggest that it is mainly inhibition of the enzyme in the tissue which participates in the mechanism of potentiation of kinin action by YS-980.


Archive | 1986

Novel benzothiazine derivatives

Jun-Ichi Iwao; Tadashi Iso; Masayuki Oya


Journal of Medicinal Chemistry | 1988

Novel calcium antagonists. Synthesis and structure-activity relationship studies of benzothiazoline derivatives.

Koji Yamamoto; Masanobu Fujita; Keizo Tabashi; Yoichi Kawashima; Eishin Kato; Masayuki Oya; Tadashi Iso; Jun-Ichi Iwao


Chemical & Pharmaceutical Bulletin | 1982

Thiol Compounds. V. Absolute Configuration and Crystal Structure of (4R)-2-(2-Hydroxyphenyl)-3-(3-mercaptopropionyl)-4-thiazolidinecarboxylic Acid

Masayuki Oya; Eishin Kato; Jun-Ichi Iwao; Noritake Yasuoka


Chemical & Pharmaceutical Bulletin | 1982

Synthesis and Antihypertensive Activity of N-(Mercaptoacyl)-thiazolidinecarboxylic Acids

Masayuki Oya; Toshio Baba; Eishin Kato; Yoichi Kawashima; Toshio Watanabe


Chemical & Pharmaceutical Bulletin | 1978

New Sulfhydryl Compounds with Potent Antihypertensive Activities

Itaru Mita; Jun-Ichi Iwao; Masayuki Oya; Takehisa Chiba; Tadashi Iso


Archive | 1981

Sulfur-containing acylamino acids

Jun-Ichi Iwao; Masayuki Oya; Tadashi Iso


Chemical & Pharmaceutical Bulletin | 1986

Conversion of thiols into disulfides with diethyl bromomalonate.

Eishin Kato; Masayuki Oya; Tadashi Iso; Jun-Ishi Iwao


Archive | 1982

Ascorbic acid derivatives

Jun-Ichi Iwao; Masayuki Oya; Tadashi Iso


Chemical & Pharmaceutical Bulletin | 1981

Thiol Compounds. I. Synthesis and Antihypertensive Activity of Mercaptoacylamino Acids

Masayuki Oya; Junzoh Matsumoto; Hideo Takashina; Jun-Ichi Iwao; Yoshihiko Funae

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Jun-Ichi Iwao

SANTEN PHARMACEUTICAL CO.

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Takehisa Chiba

SANTEN PHARMACEUTICAL CO.

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Eishin Kato

SANTEN PHARMACEUTICAL CO.

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Toshio Baba

SANTEN PHARMACEUTICAL CO.

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Toshio Watanabe

SANTEN PHARMACEUTICAL CO.

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Koji Yamamoto

SANTEN PHARMACEUTICAL CO.

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Tadashi Fujita

SANTEN PHARMACEUTICAL CO.

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Hiroshi Masuda

SANTEN PHARMACEUTICAL CO.

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