Masouda E. Amer

Nobilisitine a and B, two masanane-type alkaloids from Clivia nobilis

Abstract Two masanane-type lactone alkaloids, named nobilisitine A and B, were isolated from Egyptian Clivia nobilis and characterized by spectroscopic and chemical methods. Both compounds showed contain the same [2]benzopyrano [3,4- g ]indole ring system and therefore belong to the same subgroup of Amaryllidaceae alkaloids. In particular, nobilisitine A and B, reported as two new alkaloids, proved to be the 5 β -hydroxy-3a,11c- epi -masan-7-one and the 3-hydroxybutanoyl ester of clivonine (5a-hydroxy-5a- epi -masan-7-one), the alkaloid previously extracted from Clivia miniata and belonging to the same alkaloid subgroup. Nobilisitine B appears to be an epimer at the acyl side chain of clivatine.

Two eudesmanolides from Sonchus macrocarpus

Abstract The aerial parts of Sonchus macrocarpus afforded, in addition to known triterpenes, two new eudesmanolides.

SESQUITERPENE LACTONES FROM SONCHUS MACROCARPUS

Abstract Eight sesquiterpene lactones were isolated from the roots of Sonchus macrocarpus. The eudesmanolides 15-hydroxy-4β, 15-dihydroreynosin and 15-hydroxy-4β, 15, 11β, 13-tetrahydroreynosin were isolated for the first time.

A coumestan from Lotus creticus

Abstract 8-(γ,γ-dimethyl-allyl)-1-Methoxycoumestrol has been isolated for the first time from the roots of Lotus creticus along with some known compounds. The new structure was elucidated by spectroscopic methods.

Two sesquiterpene fucopyranosides from Carthamus mareoticus

Abstract The aerial part of Carthamus mareoticus afforded, in addition to know triterpenes, two new epimeric fueopyranosides of a sesquiterpene alcohol. The structures were elucidated by spectroscopic methods.

Cornigerin, a new sesqui-lignan from the hepatoprotective fractions of Cynara cornigera L

The ethanol extract of Cynara cornigera L. was fractionated and the fractions were subjected to hepatoprotective assays using Wistar albino rats at a dose of 500 and 250mg/kg. The liver injury was induced in rats using carbon tetrachloride. Biochemical parameters such as aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) and total bilirubin were estimated as reflections of the liver condition, with silymarin as a positive control. Phytochemical investigation and chromatographic separation of the hepatoprotective fractions led to the isolation of a new sesqui-lignan namely cornigerin (1), along with eight known compounds: apigenin (2), luteolin (3), β-sitosterol glycoside (4), apigenin 7-O-β-D-glucopyranoside (5), luteolin-7-O-β-D-glucopyranoside (6), apigenin-7-O-rutinoside (7), cynarin 1,5-di-O-caffeoylquinic acid (8), and apigenin-7-O-β-D-glucuronide (9). This is the first report for the isolation of 8 and 9 from this plant.