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Dive into the research topics where Mateja Ožanič is active.

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Featured researches published by Mateja Ožanič.


Journal of Immunology | 2017

NKG2D Promotes B1a Cell Development and Protection against Bacterial Infection

Maja Lenartić; Vedrana Jelenčić; Biljana Zafirova; Mateja Ožanič; Valentina Marečić; Slaven Jurković; Veronika Sexl; Marina Šantić; Felix M. Wensveen; Bojan Polić

NKG2D is a potent activating receptor that is expressed on cytotoxic immune cells such as CD8 T and NK cells, where it promotes cytotoxicity after binding stress ligands on infected or transformed cells. On NK cell precursors NKG2D modulates proliferation and maturation. Previously, we observed that NKG2D deficiency affects peripheral B cell numbers. In this study, we show that NKG2D regulates B1a cell development and function. We find that mice deficient for NKG2D have a strong reduction of B1a cell numbers. As a result, NKG2D-deficient mice produce significantly less Ag-specific IgM Abs upon immunization with T cell–independent Ags, and they are more susceptible to Gram-negative sepsis. Klrk1−/− B1a cells are also functionally impaired and they fail to provide protection against Francisella novicida upon adoptive transfer. Using mixed bone marrow chimeric mice, we show that the impact of NKG2D deficiency on B1a cell development is cell intrinsic. No changes in homeostatic turnover and homing of B cells were detectable, limiting the effects of NKG2D to modulation of the hematopoietic development of B1a cells. Using conditional ablation, we demonstrate that the effect of NKG2D on B1a cell development occurs at a developmental stage that precedes the common lymphoid progenitor. Our findings reveal an unexpected new role for NKG2D in the regulation of B1a cell development. The protective effects of this activating receptor therefore reach beyond that of cytotoxic cells, stimulating the immune system to fight bacterial infections by promoting development of innate-like B cells.


Prvi hrvatski kongres o biosigurnosti i biozaštiti | 2017

Evaluation of effectiveness of chemical disinfectants on the growth of Francisella novicida-growing amoebae

Nikolina Špoljarić; Valentina Marečić; Mateja Ožanič; Marina Šantić


Archive | 2016

Priručnik za vježbe iz opće mikrobiologije

Roberto Antolović; Jadranka Frece; Ivana Gobin; Jasna Hrenović; Blaženka Kos; Ksenija Markov; Emilija Mlinarić-Missoni; Jasna Novak; Mateja Ožanič; Ljiljana Pinter; Vanda Plečko; Sanja Pleško; Marina Šantić; Maja Šegvić Klarić; Martina Šeruga Musić; Dijana Škorić; Jagoda Šušković


Archive | 2016

Novi pristup razumijevanju bakterije Francisella tularensis

Mateja Ožanič; Valentina Marečić; Mihaela Matovina; Mirna Mihelčić; Alemka Markotić; Petra Svoboda; Nenad Turk; Josipa Habuš; Marina Šantić


Archive | 2016

Manual for the exercise of general microbiology

Roberto Antolović; Jadranka Frece; Ivana Gobin; Jasna Hrenović; Blaženka Kos; Ksenija Markov; Emilija Mlinarić-Missoni; Jasna Novak; Mateja Ožanič; Ljiljana Pinter; Vanda Plečko; Sanja Pleško; Marina Šantić; Maja Šegvić Klarić; Martina Šeruga Musić; Dijana Škorić; Jagoda Šušković


Medicina Fluminensis : Medicina Fluminensis | 2016

Unutarstanični život bakterija Francisella i Legionella u amebama

Mateja Ožanič; Valentina Marečić; Ivana Gobin; Marina Šantić


Medicina : glasilo Hrvatskoga liječničkoga zbora, Podružnica Rijeka | 2016

Intracellular life of Francisella and Legionella within amoebae cells

Mateja Ožanič; Valentina Marečić; Ivana Gobin; Marina Šantić


6th Croatian Congress of Microbiology with International Participation | 2016

The influence of the Zn ions on the survival rate of Francisella tularensis subsp. holarctica LVS strain in water

Andrea Majstorović; Mateja Ožanič; Valentina Marečić; Marina Šantić


3. kongres sanitarne profesije | 2016

Testing the effectiveness of disinfectants 0, 2% Bigvasan, 1% Descocid and 5% Asepsol eko in the destruction of Francisella tularensis subsp. novicida

Nikolina Špoljarić; Diana Jurčić-Momčilović; Mateja Ožanič; Valentina Marečić; Marina Šantić


Archive | 2014

Mikrobiologija hrane i vode

Marina Šantić; Ivana Gobin; Mateja Ožanič; Valentina Marečić

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