Mateja Ožanič
University of Rijeka
Network
Latest external collaboration on country level. Dive into details by clicking on the dots.
Publication
Featured researches published by Mateja Ožanič.
Journal of Immunology | 2017
Maja Lenartić; Vedrana Jelenčić; Biljana Zafirova; Mateja Ožanič; Valentina Marečić; Slaven Jurković; Veronika Sexl; Marina Šantić; Felix M. Wensveen; Bojan Polić
NKG2D is a potent activating receptor that is expressed on cytotoxic immune cells such as CD8 T and NK cells, where it promotes cytotoxicity after binding stress ligands on infected or transformed cells. On NK cell precursors NKG2D modulates proliferation and maturation. Previously, we observed that NKG2D deficiency affects peripheral B cell numbers. In this study, we show that NKG2D regulates B1a cell development and function. We find that mice deficient for NKG2D have a strong reduction of B1a cell numbers. As a result, NKG2D-deficient mice produce significantly less Ag-specific IgM Abs upon immunization with T cell–independent Ags, and they are more susceptible to Gram-negative sepsis. Klrk1−/− B1a cells are also functionally impaired and they fail to provide protection against Francisella novicida upon adoptive transfer. Using mixed bone marrow chimeric mice, we show that the impact of NKG2D deficiency on B1a cell development is cell intrinsic. No changes in homeostatic turnover and homing of B cells were detectable, limiting the effects of NKG2D to modulation of the hematopoietic development of B1a cells. Using conditional ablation, we demonstrate that the effect of NKG2D on B1a cell development occurs at a developmental stage that precedes the common lymphoid progenitor. Our findings reveal an unexpected new role for NKG2D in the regulation of B1a cell development. The protective effects of this activating receptor therefore reach beyond that of cytotoxic cells, stimulating the immune system to fight bacterial infections by promoting development of innate-like B cells.
Prvi hrvatski kongres o biosigurnosti i biozaštiti | 2017
Nikolina Špoljarić; Valentina Marečić; Mateja Ožanič; Marina Šantić
Archive | 2016
Roberto Antolović; Jadranka Frece; Ivana Gobin; Jasna Hrenović; Blaženka Kos; Ksenija Markov; Emilija Mlinarić-Missoni; Jasna Novak; Mateja Ožanič; Ljiljana Pinter; Vanda Plečko; Sanja Pleško; Marina Šantić; Maja Šegvić Klarić; Martina Šeruga Musić; Dijana Škorić; Jagoda Šušković
Archive | 2016
Mateja Ožanič; Valentina Marečić; Mihaela Matovina; Mirna Mihelčić; Alemka Markotić; Petra Svoboda; Nenad Turk; Josipa Habuš; Marina Šantić
Archive | 2016
Roberto Antolović; Jadranka Frece; Ivana Gobin; Jasna Hrenović; Blaženka Kos; Ksenija Markov; Emilija Mlinarić-Missoni; Jasna Novak; Mateja Ožanič; Ljiljana Pinter; Vanda Plečko; Sanja Pleško; Marina Šantić; Maja Šegvić Klarić; Martina Šeruga Musić; Dijana Škorić; Jagoda Šušković
Medicina Fluminensis : Medicina Fluminensis | 2016
Mateja Ožanič; Valentina Marečić; Ivana Gobin; Marina Šantić
Medicina : glasilo Hrvatskoga liječničkoga zbora, Podružnica Rijeka | 2016
Mateja Ožanič; Valentina Marečić; Ivana Gobin; Marina Šantić
6th Croatian Congress of Microbiology with International Participation | 2016
Andrea Majstorović; Mateja Ožanič; Valentina Marečić; Marina Šantić
3. kongres sanitarne profesije | 2016
Nikolina Špoljarić; Diana Jurčić-Momčilović; Mateja Ožanič; Valentina Marečić; Marina Šantić
Archive | 2014
Marina Šantić; Ivana Gobin; Mateja Ožanič; Valentina Marečić