Matheus Pintanel Freitas

Are physical activity levels associated with better health outcomes in people with epilepsy

The aim of the study was to investigate the association of physical activity in three categories (inactive, insufficiently active and active) with health outcomes in people with epilepsy. The dependent variables and the instruments used in the study were: a) quality of life - measured by Quality of Life in Epilepsy-31 for adults and Quality of Life in Epilepsy for Adolescents, b) side effects of medication - measured by Adverse Events Profile, c) depression - measured by Neurological Disorders Depression Inventory for Epilepsy, and d) state and trait anxiety - measured by State-Trait Anxiety Inventory. Physical activity levels were analyzed using the International Physical Activity Questionnaire (IPAQ) for adults in the commuting and leisure domains and Physical Activity Questionnaire for Adolescents (PAQ-A). Simple and multiple linear regression was used in the statistical analysis. The cross-sectional study with one hundred and one individuals was conducted in Pelotas/RS, Brazil, at the Neurology Clinic of the Faculty of Medicine of the Federal University of Pelotas. In the crude analysis, physical activity was positively associated with quality of life (p<0.001) and negatively associated with depression (p=0.046), state of anxiety (p=0.014), trait of anxiety (p=0.015) and side effect of medication (p=0.01). In addition, physical activity levels explained 10% of the quality of life (R2=0.10). In the adjusted analysis, physical activity remained associated with side effect of medication (p=0.014) and was not associated with trait anxiety (p=0.066). However, quality of life showed a positive linear trend (p=0.001) while depression (p=0.033) and anxiety state (p=0.004) showed a negative trend according to physical activity levels. Physical activity was associated with health outcomes, and can be a nonpharmacological treatment in people with epilepsy for improving health and life conditions.

PROJETO EF+: IMPLICAÇÕES PEDAGÓGICAS E NÍVEL DE CONHECIMENTO SOBRE SAÚDE

The objective was to verify the impact of “Educação Física+: Praticando Saúde na Escola” intervention on teaching practices and health knowledge of schoolchildren from Canguçu city, southern Brazil. Fifteen schools participated in the study (group 1: schools that joined the intervention in the year of 2011; group 2: schools that joined the intervention in the year of 2012). This study was carried out by two years with 883 schoolchildren and 13 teachers. The schollchildren knowledge of health was improved in the post-intervention (p<0.001), with higher scores in group 1. It was found tendency to increase the level of knowledge according to the number of lesson plans developed by teachers (p<0.001). Of the teachers interviewed (n= 13), most adhered to the activities proposed (n = 8) and perceived positive changes, specially in the students, who questioned more about the subject in the classrom and bring these knowledge to their parents. Almost all teachers who adhered to the intervention did not report difficulties to develop the lessons plans (n=7). It was concluded that a short-term intervention improved the schoolchildren level of knowledge on physical activity and health and presented positive impacts on teachers professional practice.

EFEITOS DO EXERCÍCIO FÍSICO SOBRE O SISTEMA IMUNE DE MULHERES PÓS-MENOPAUSADAS: REVISÃO SISTEMÁTICA

As mulheres na menopausa sofrem mudancas endocrinas que acarretam uma serie de disfuncoes, inclusive a atenuacao da resposta imune. Nesse sentido, realizou-se uma revisao sistematica da literatura que objetivou buscar ensaios clinicos randomizados (ECR) que verificassem o efeito do exercicio fisico na imunomodulacao em mulheres pos-menopausadas. Utilizaram-se as bases de dados eletronicas Medline/PubMed, SciELO, Scopus, Lilacs e Bireme, com as seguintes palavras-chave: humans, immune system, physical activity, exercise, physical fitness, postmenopause e postmenopausal period. Utilizou-se como criterio de exclusao dos titulos e resumos, os artigos que deixavam claro nao tratar do efeito do exercicio/atividade fisica sobre o sistema imune e artigos que estudaram mulheres com câncer e/ou diabetes. Foram incluidos sete artigos para analise. As intervencoes duraram de seis meses a 19,9 anos, com amostras variando de 18 a 421 pessoas. Todos os estudos utilizaram o exercicio aerobio moderado como intervencao. Apenas um estudo utilizou medida subjetiva para avaliar o sistema imune, sendo que os demais estudos utilizaram medidas bioquimicas diretas. Com relacao ao efeito do exercicio sobre a imunomodulacao, 57,1% dos ECR concluiram que o exercicio fisico atuou positivamente sobre o sistema imune de mulheres menopausadas e nenhum mostrou efeito negativo. A proteina C reativa e a contagem de celulas imunologicas foram as mais pesquisadas, com quatro estudos cada, nos quais, apenas um de cada variavel mostrou associacao significativa na diminuicao desses parâmetros. Tres estudos pesquisaram a variavel interleucina-6 e dois, a amiloide A, sem demonstrar associacao significativa; dos dois estudos que avaliaram imunoglobulinas, apenas um mostrou associacao para o aumento da imunoglobulina A. Concluiu-se que e pouco provavel que o exercicio aerobio prejudique o sistema imune de mulheres menopausadas e e necessaria a realizacao de novos ECR que objetivem verificar as mudancas na imunomodulacao dessa populacao e que abranjam diferentes volumes e tipos de exercicio fisico.Menopausal women undergo endocrine changes that cause multiple disorders, including attenuation of the immune response. In this sense, a systematic review of the literature was conducted aiming to find randomized controlled trials (RCTs) which had studied the effect of physical exercise on immune modulation in postmenopausal women. Electronic databases of Medline/PubMed, SciELO, Scopus, Lilacs, and Bireme were used with the following keywords: humans, immune system, physical activity, exercise, physical fitness, postmenopause and postmenopausal period. The exclusion criteria for titles and abstracts were any article that clearly did not address the effect of exercise/ physical activity on the immune system and those that investigated women with cancer and/or diabetes. Seven articles were included for analysis. Interventions lasted from six months to 19.9 years, with samples ranging from 18 to 421 subjects. All studies used moderate aerobic exercise as intervention. Only one study used subjective measure to evaluate the immune system and the remaining studies used direct biochemical measurements. Regarding the effect of exercise on immune modulation, 57.1% of the RCT concluded that physical exercise acted positively on immune system of menopausal women and showed no negative effect. C-reactive protein and immune cell count were the most researched variables, with four studies each, where only one in each variable was significantly associated with decrease in these parameters. Three studies investigated the variable interleukin-6 and two investigated the serum amyloid A, showing no significant association; of the two studies evaluating immunoglobulins, only one showed an association with increased immunoglobulin A. We concluded that it is no likely that aerobic exercise impairs the immune system in postmenopausal women, and is necessary to perform new RCTs to study the changes in immune modulation in this population and to address different volumes and types of exercise.

EFECTOS DEL EJERCICIO FÍSICO SOBRE EL SISTEMA INMUNE EN MUJERES POSMENOPÁUSICAS: REVISIÓN SISTEMÁTICA

As mulheres na menopausa sofrem mudancas endocrinas que acarretam uma serie de disfuncoes, inclusive a atenuacao da resposta imune. Nesse sentido, realizou-se uma revisao sistematica da literatura que objetivou buscar ensaios clinicos randomizados (ECR) que verificassem o efeito do exercicio fisico na imunomodulacao em mulheres pos-menopausadas. Utilizaram-se as bases de dados eletronicas Medline/PubMed, SciELO, Scopus, Lilacs e Bireme, com as seguintes palavras-chave: humans, immune system, physical activity, exercise, physical fitness, postmenopause e postmenopausal period. Utilizou-se como criterio de exclusao dos titulos e resumos, os artigos que deixavam claro nao tratar do efeito do exercicio/atividade fisica sobre o sistema imune e artigos que estudaram mulheres com câncer e/ou diabetes. Foram incluidos sete artigos para analise. As intervencoes duraram de seis meses a 19,9 anos, com amostras variando de 18 a 421 pessoas. Todos os estudos utilizaram o exercicio aerobio moderado como intervencao. Apenas um estudo utilizou medida subjetiva para avaliar o sistema imune, sendo que os demais estudos utilizaram medidas bioquimicas diretas. Com relacao ao efeito do exercicio sobre a imunomodulacao, 57,1% dos ECR concluiram que o exercicio fisico atuou positivamente sobre o sistema imune de mulheres menopausadas e nenhum mostrou efeito negativo. A proteina C reativa e a contagem de celulas imunologicas foram as mais pesquisadas, com quatro estudos cada, nos quais, apenas um de cada variavel mostrou associacao significativa na diminuicao desses parâmetros. Tres estudos pesquisaram a variavel interleucina-6 e dois, a amiloide A, sem demonstrar associacao significativa; dos dois estudos que avaliaram imunoglobulinas, apenas um mostrou associacao para o aumento da imunoglobulina A. Concluiu-se que e pouco provavel que o exercicio aerobio prejudique o sistema imune de mulheres menopausadas e e necessaria a realizacao de novos ECR que objetivem verificar as mudancas na imunomodulacao dessa populacao e que abranjam diferentes volumes e tipos de exercicio fisico.Menopausal women undergo endocrine changes that cause multiple disorders, including attenuation of the immune response. In this sense, a systematic review of the literature was conducted aiming to find randomized controlled trials (RCTs) which had studied the effect of physical exercise on immune modulation in postmenopausal women. Electronic databases of Medline/PubMed, SciELO, Scopus, Lilacs, and Bireme were used with the following keywords: humans, immune system, physical activity, exercise, physical fitness, postmenopause and postmenopausal period. The exclusion criteria for titles and abstracts were any article that clearly did not address the effect of exercise/ physical activity on the immune system and those that investigated women with cancer and/or diabetes. Seven articles were included for analysis. Interventions lasted from six months to 19.9 years, with samples ranging from 18 to 421 subjects. All studies used moderate aerobic exercise as intervention. Only one study used subjective measure to evaluate the immune system and the remaining studies used direct biochemical measurements. Regarding the effect of exercise on immune modulation, 57.1% of the RCT concluded that physical exercise acted positively on immune system of menopausal women and showed no negative effect. C-reactive protein and immune cell count were the most researched variables, with four studies each, where only one in each variable was significantly associated with decrease in these parameters. Three studies investigated the variable interleukin-6 and two investigated the serum amyloid A, showing no significant association; of the two studies evaluating immunoglobulins, only one showed an association with increased immunoglobulin A. We concluded that it is no likely that aerobic exercise impairs the immune system in postmenopausal women, and is necessary to perform new RCTs to study the changes in immune modulation in this population and to address different volumes and types of exercise.

PHYSICAL EXERCISE EFFECTS ON THE IMMUNE SYSTEM IN POSTMENOPAUSAL WOMEN: SYSTEMATIC REVIEW

As mulheres na menopausa sofrem mudancas endocrinas que acarretam uma serie de disfuncoes, inclusive a atenuacao da resposta imune. Nesse sentido, realizou-se uma revisao sistematica da literatura que objetivou buscar ensaios clinicos randomizados (ECR) que verificassem o efeito do exercicio fisico na imunomodulacao em mulheres pos-menopausadas. Utilizaram-se as bases de dados eletronicas Medline/PubMed, SciELO, Scopus, Lilacs e Bireme, com as seguintes palavras-chave: humans, immune system, physical activity, exercise, physical fitness, postmenopause e postmenopausal period. Utilizou-se como criterio de exclusao dos titulos e resumos, os artigos que deixavam claro nao tratar do efeito do exercicio/atividade fisica sobre o sistema imune e artigos que estudaram mulheres com câncer e/ou diabetes. Foram incluidos sete artigos para analise. As intervencoes duraram de seis meses a 19,9 anos, com amostras variando de 18 a 421 pessoas. Todos os estudos utilizaram o exercicio aerobio moderado como intervencao. Apenas um estudo utilizou medida subjetiva para avaliar o sistema imune, sendo que os demais estudos utilizaram medidas bioquimicas diretas. Com relacao ao efeito do exercicio sobre a imunomodulacao, 57,1% dos ECR concluiram que o exercicio fisico atuou positivamente sobre o sistema imune de mulheres menopausadas e nenhum mostrou efeito negativo. A proteina C reativa e a contagem de celulas imunologicas foram as mais pesquisadas, com quatro estudos cada, nos quais, apenas um de cada variavel mostrou associacao significativa na diminuicao desses parâmetros. Tres estudos pesquisaram a variavel interleucina-6 e dois, a amiloide A, sem demonstrar associacao significativa; dos dois estudos que avaliaram imunoglobulinas, apenas um mostrou associacao para o aumento da imunoglobulina A. Concluiu-se que e pouco provavel que o exercicio aerobio prejudique o sistema imune de mulheres menopausadas e e necessaria a realizacao de novos ECR que objetivem verificar as mudancas na imunomodulacao dessa populacao e que abranjam diferentes volumes e tipos de exercicio fisico.Menopausal women undergo endocrine changes that cause multiple disorders, including attenuation of the immune response. In this sense, a systematic review of the literature was conducted aiming to find randomized controlled trials (RCTs) which had studied the effect of physical exercise on immune modulation in postmenopausal women. Electronic databases of Medline/PubMed, SciELO, Scopus, Lilacs, and Bireme were used with the following keywords: humans, immune system, physical activity, exercise, physical fitness, postmenopause and postmenopausal period. The exclusion criteria for titles and abstracts were any article that clearly did not address the effect of exercise/ physical activity on the immune system and those that investigated women with cancer and/or diabetes. Seven articles were included for analysis. Interventions lasted from six months to 19.9 years, with samples ranging from 18 to 421 subjects. All studies used moderate aerobic exercise as intervention. Only one study used subjective measure to evaluate the immune system and the remaining studies used direct biochemical measurements. Regarding the effect of exercise on immune modulation, 57.1% of the RCT concluded that physical exercise acted positively on immune system of menopausal women and showed no negative effect. C-reactive protein and immune cell count were the most researched variables, with four studies each, where only one in each variable was significantly associated with decrease in these parameters. Three studies investigated the variable interleukin-6 and two investigated the serum amyloid A, showing no significant association; of the two studies evaluating immunoglobulins, only one showed an association with increased immunoglobulin A. We concluded that it is no likely that aerobic exercise impairs the immune system in postmenopausal women, and is necessary to perform new RCTs to study the changes in immune modulation in this population and to address different volumes and types of exercise.

Mode of administration does matter: comparability study using IPAQ

Este estudio comparo la pontuacion total y las puntuaciones aisladas de los dominios de actividad fisica evaluados a traves de cuatro variaciones del IPAQ version larga: (a) semana tipica, administrado por un entrevistador; (b) semana tipica, autoadministrado; (c) ultimos siete dias, entrevistador; (d) ultimos siete dias, autoadministrado. La muestra incluyo a 38 estudiantes universitarios de educacion fisica. Puntajes de auto-reporte eran, en general, dos veces mas alto que entrevista, sin tener en cuenta el periodo de recuerdo. En cuanto a las puntuaciones de los dominios aislados, las puntuaciones de actividad fisica en el trabajo generados por su propio informe eran 6-7 veces mayores que las originadas a partir de entrevistas. Se observo la misma tendencia para la actividad fisica de los hogares. Las puntuaciones de actividad fisica de transporte no cambiaron de acuerdo con el modo de administracion. En terminos de actividad fisica en el tiempo libre, las puntuaciones fueron similares a excepcion de los ultimos siete dias administrado por entrevistador, que eran inferiores a los otros tres. En conclusion, puntuaciones mas altas se obtienen a traves del auto-informe, en comparacion con las entrevistas, probablemente por la mala interpretacion del instrumento en el modo de auto-informe. El periodo de recuerdo tuvo poco efecto sobre las estimaciones de actividad fisica.