Matt Aaron Tschantz | Researchain

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Featured researches published by Matt Aaron Tschantz.

Tetrahedron Letters | 2002

Isoquinolinone synthesis by SNAr reaction: a versatile route to imidazo[4,5-h]isoquinolin-9-ones

Roger J. Snow; Tanja Butz; Abdelhakim Hammach; Suresh R. Kapadia; Tina Marie Morwick; Anthony S. Prokopowicz; Hidenori Takahashi; Jonathan Tan; Matt Aaron Tschantz; Xiao-Jun Wang

Abstract Reaction of 2-chlorobenzonitriles with β-ketoesters in an S N Ar reaction, followed by cyclization in acid provides a versatile route to isoquinolones. Starting from 2,6-dichloro-3-nitrobenzonitrile 7 , sequential displacement of the chlorines by an amine and a β-ketoester leads to imidazo[4,5- h ]isoquinolin-9-ones 1 , a new class of kinase inhibitor.

Archive | 2001

Heterocyclic compounds useful as inhibitors of tyrosine kinases

Roger J. Snow; Mario G. Cardozo; Daniel R. Goldberg; Abdelhakim Hammach; Tina Marie Morwick; Neil Moss; Usha R. Patel; Anthony S. Prokopowicz; Hidenori Takahashi; Matt Aaron Tschantz; Xiao-Jun Wang

Journal of Medicinal Chemistry | 1997

Effect of structural modification of enol-carboxamide-type nonsteroidal antiinflammatory drugs on COX-2/COX-1 selectivity.

Edward S. Lazer; Clara K. Miao; Charles L. Cywin; Ronald John Sorcek; Hin-Chor Wong; Zhaoxing Meng; Ian Potocki; Maryann Hoermann; Roger J. Snow; Matt Aaron Tschantz; Terence A. Kelly; Daniel W. McNeil; Simon J. Coutts; Laurie Churchill; Anne G. Graham; Eva David; Peter M. Grob; Wolfhard Engel; Hans Meier; Gunter Trummlitz

Journal of Medicinal Chemistry | 2002

Discovery of 2-Phenylamino-imidazo[4,5-h]isoquinolin-9-ones: A New Class of Inhibitors of Lck Kinase

Roger J. Snow; Mario G. Cardozo; Tina Morwick; Carl A. Busacca; Yong Dong; Robert J. Eckner; Stephen P. Jacober; Scott Jakes; Suresh R. Kapadia; Susan Lukas; Maret Panzenbeck; Gregory W. Peet; Jeffrey D. Peterson; Anthony S. Prokopowicz; Rosemarie Sellati; Robert M. Tolbert; Matt Aaron Tschantz; Neil Moss

Journal of Medicinal Chemistry | 2003

Optimization of 2-phenylaminoimidazo[4,5-h]isoquinolin-9-ones: orally active inhibitors of lck kinase.

Daniel R. Goldberg; Tanja Butz; Mario G. Cardozo; Robert J. Eckner; Abdelhakim Hammach; Jessica Huang; Scott Jakes; Suresh R. Kapadia; Mohammed A. Kashem; Susan Lukas; Tina Morwick; Maret Panzenbeck; Usha R. Patel; Susan Pav; Gregory W. Peet; Jeffrey D. Peterson; Anthony S. Prokopowicz; Roger J. Snow; Rosemarie Sellati; Hidenori Takahashi; Jonathan Tan; Matt Aaron Tschantz; Xiao-Jun Wang; Yong Wang; John P. Wolak; Pla Xiong; Neil Moss

Journal of Organic Chemistry | 1995

Asymmetric Lewis Acid-Catalyzed Addition of a Ketene Dithioacetal to a Chiral Bicyclic Lactam. Formation of Cyclobutanopyrrolidinones. A New Class of GABA Derivatives

A. I. Meyers; Matt Aaron Tschantz; Gregory P. Brengel

Archive | 2003

DERIVATIVES OF [6,7-DIHYDRO-5H-IMIDAZO[1,2-α]IMIDAZOLE-3-SULFONYL]-PYRROLIDINE-2-CARBOXYLIC ACID AMIDE AS ANTI-INFLAMMATORY AGENTS

Terence A. Kelly; Jin Mi Kim; Rene Marc Lemieux; Matt Aaron Tschantz

Journal of Organic Chemistry | 1999

4-Trifloxy-9-SEM-β-Carboline: Preparation and Synthetic Utility

Carl A. Busacca; Magnus Eriksson; Yong Dong; Anthony S. Prokopowicz; and Annette M. Salvagno; Matt Aaron Tschantz

Archive | 2010

Derivatives of 6,7-dihydro-5h-imidazo[1,2-.alpha.]imidazole-3-carboxylic acid amides

Antonio Jose del Moral Barbosa; Joerg Martin Bentzien; Steven Richard Brunette; Zhidong Chen; Derek Cogan; Donghong A. Gao; Alexander Heim-Riether; Joshua Courtney Horan; Jennifer A. Kowalski; Michael David Lawlor; Rene Marc Lemieux; Weimin Liu; Bryan Mckibben; Craig Andrew Miller; Neil Moss; Matt Aaron Tschantz; Zhaoming Xiong; Hui Yu; Yang Yu

Archive | 2004