Matthew Duncton

Stereoselective synthesis of the indolizinoindole ring system

We report a novel, facile and stereoselective approach to the indolizino[8,7-b]indole ring system from a readily available, non-racemic chiral template.

Preparation of 6-chloro-5-fluoroindole via the use of palladium and copper-mediated heterocyclisations

Abstract The title indole, the heterocyclic core of the 5-HT2C receptor agonist Ro 60-0175, was prepared by a modification to the Stille indole synthesis, or by the method of Gonzalez and co-workers.

Use of a Modified Leimgruber–Batcho Reaction to Prepare 6‐Chloro‐5‐fluoroindole

Abstract An efficient synthesis of the title indole, the heterocyclic core of the standard 5‐HT2C receptor agonist Ro 60‐0175, via a modified Leimgruber–Batcho indole synthesis is presented. The process can be used to make >100 g quantities of the target indole.

EFFICIENT SYNTHESIS OF THE 5-HT2C RECEPTOR AGONIST, ORG 37684

An efficient synthesis of the 5-HT2C receptor agonist Org 37684 is presented. The synthesis utilises the regioselective demethylation of an arylether as the key step.