Matthew I. Arhewoh

Crystallography and Biopharmaceutics of Some Antimalarials

Crystallography is a branch of science that deals with the discerning of the arrangement and bonding of atoms in crystalline solids. Crystal structural differences in the active pharmaceutical ingredient (API)/excipients in multi - source generics of antimal arials may present differences in their physicochemical properties and ultimately the rate and extent of drug absorption. Tackling the menace of the continuing spread of multi - drug resistant Plasmodium falciparum malaria may require the evaluation of the c rystal structural influences of orally administered drugs on antimalarial bioavailability.

Characterization of Acid Treated Porcine Mucin and its Effects on Bioadhesion

Polymers of various sources, whether of synthetic or natural origin continue to find increased applications in drug delivery formulations. Attempts to improve the functionality of these polymers have led to their modifications. Modified forms of some polymers have been reported to exhibit improved properties and the dosage forms formulated with them showing superior performance when compared with those of the unmodified form. Examples of some products that have undergone modification resulting in improved modified products includes cellulose and chitin. The incorporation of a sodium carboxymethyl group onto the cellulose backbone or the acid treatment of α-cellulose have resulted in sodium carboxymethyl cellulose and microcrystalline cellulose, respectively while the alkaline treatment of chitin have resulted in chitosan. These modifications have sometimes resulted in the total change of the polymer properties. Mucin, a bioadhesive polymer of natural origin has been identified as useful material in drug formulations. It is highly abundant in human and animal tissues, hence it is biocompatible, non-toxic and easily