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Matthew Stirling

Millennium Pharmaceuticals

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Publication

Featured researches published by Matthew Stirling.

ACS Medicinal Chemistry Letters | 2015

MLN8054 and Alisertib (MLN8237): Discovery of Selective Oral Aurora A Inhibitors

Todd B. Sells; Ryan Chau; Jeffrey A. Ecsedy; Rachel E. Gershman; Kara M. Hoar; Jessica Huck; David A. Janowick; Vivek J. Kadambi; Patrick J. LeRoy; Matthew Stirling; Stephen G. Stroud; Tricia J. Vos; Deborah R. Wysong; Mengkun Zhang; Suresh K. Balani; Joseph B. Bolen; Mark Manfredi; Christopher F. Claiborne

The Aurora kinases are essential for cell mitosis, and the dysregulation of Aurora A and B have been linked to the etiology of human cancers. Investigational agents MLN8054 (8) and alisertib (MLN8237, 10) have been identified as high affinity, selective, orally bioavailable inhibitors of Aurora A that have advanced into human clinical trials. Alisertib (10) is currently being evaluated in multiple Phase II and III clinical trials in hematological malignancies and solid tumors.

ACS Combinatorial Science | 2002

Design, Synthesis, and Biological Evaluation of a Library of 1-(2-Thiazolyl)-5-(trifluoromethyl)pyrazole-4-carboxamides

Bridget A. Donohue; Enrique Luis Michelotti; John C. Reader; Valerie Reader; Matthew Stirling; Colin M. Tice

Archive | 2005

Lactam compounds useful as protein kinase inhibitors

Christopher Blackburn; Christopher F. Claiborne; Courtney Cullis; Natalie A. Dales; Michael A. Patane; Matthew Stirling; Omar G. Stradella

Archive | 2012

INHIBITORS OF NEDD8-ACTIVATING ENZYME

Ashley Sue Mccarron; Todd B. Sells; Matthew Stirling; Stephen G. Stroud

Medicinal Research Reviews | 2005

Preparation of kinase-biased compounds in the search for lead inhibitors of kinase targets†

Justine Y.Q. Lai; Steven P. Langston; Ruth Adams; Rebekah E. Beevers; Richard J. Boyce; Svenja Burckhardt; James M. Cobb; Yvonne Ferguson; Eva Figueroa; Neil Grimster; Andrew H. Henry; Nawaz Mohammed Khan; Kerry Jenkins; Mark W. Jones; Robert Judkins; Jeremy Major; Abid Masood; James Nally; Helen Payne; Lloyd J. Payne; Gilles Raphy; Tony Raynham; John C. Reader; Valerie Reader; Alison Reid; Parminder Ruprah; Michael Shaw; Hannah Fiona Sore; Matthew Stirling; Adam Talbot

Archive | 2008

Process for the synthesis of E1 activating enzyme inhibitors

Ian Armitage; Eric L. Elliott; Marianne Langston; Steven P. Langston; Quentin J. McCubbin; Hirotake Mizutani; Matthew Stirling; Lei Zhu

Archive | 2017

inibidores de enzima ativadora de nedd8

Ashley McCarron; Matthew Stirling; Stephen G. Stroud; Todd B. Sells

Archive | 2014

FORMA CRISTALINA DEL SULFAMATO DE {(1S,2S,4R)-4-[(6-{[(1R,2S)-5-CLORO-2-METOXI-2,3-DIHIDRO-1H-INDEN-1-IL]AMINO}PIRIMIDIN-4-IL)OXI]-2-HIDROXICICLOPENTIL}METILO, COMPOSICIONES FARMACEUTICAS QUE LA CONTIENEN Y USO DE LAS MISMAS PARA TRATAR CANCER

Ashley Sue Mcarron; Todd B. Sells; Matthew Stirling; Stephen G. Stroud

Archive | 2012

Inhibiteurs de l'enzyme activant nedd8

Ashley McCarron; Todd B. Sells; Matthew Stirling; Stephen G. Stroud

Archive | 2008

Process for the synthesis of intermediates compounds useful for the preparation of E1 activity activating enzyme inhibitors

Ian Armitage; Eric L. Elliot; Marianne Langston; Steven P. Langston; Quentin J. McCubbin; Hirotake Mizutani; Matthew Stirling; Lei Zhu

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Stephen G. Stroud

Millennium Pharmaceuticals

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Steven P. Langston

Millennium Pharmaceuticals

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Todd B. Sells

Millennium Pharmaceuticals

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Hirotake Mizutani

Millennium Pharmaceuticals

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Christopher F. Claiborne

Millennium Pharmaceuticals

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Quentin J. McCubbin

Millennium Pharmaceuticals

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Christopher Blackburn

Millennium Pharmaceuticals

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Courtney Cullis

Millennium Pharmaceuticals

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Eric L. Elliot

Millennium Pharmaceuticals

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Ian Armitage

Takeda Pharmaceutical Company

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