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Featured researches published by Matthias Scheich.


Diagnostic Pathology | 2007

Differential diagnosis of laryngeal spindle cell carcinoma and inflammatory myofibroblastic tumor – report of two cases with similar morphology

Hans-Ullrich Völker; Matthias Scheich; Sylvia Höller; Philipp Ströbel; Rudolf Hagen; Hans Konrad Müller-Hermelink; Matthias Eck

BackgroundSpindle cell tumors of the larynx are rare. In some cases, the dignity is difficult to determine. We report two cases of laryngeal spindle cell tumors.Case presentationCase 1 is a spindle cell carcinoma (SPC) in a 55 year-old male patient and case 2 an inflammatory myofibroblastic tumor (IMT) in a 34 year-old female patient. A comprehensive morphological and immunohistochemical analysis was done. Both tumors arose at the vocal folds. Magnified laryngoscopy showed polypoid tumors. After resection, conventional histological investigation revealed spindle cell lesions with similar morphology. We found ulceration, mild atypia, and myxoid stroma. Before immunohistochemistry, the dignity was uncertain. Immunohistochemical investigations led to diagnosis of two distinct tumors with different biological behaviour. Both expressed vimentin. Furthermore, the SPC was positive for pan-cytokeratin AE1/3, CK5/6, and smooth-muscle actin, whereas the IMT reacted with antibodies against ALK-1, and EMA. The proliferation (Ki67) was up to 80% in SPC and 10% in IMT. Other stainings with antibodies against p53, p21, Cyclin D1, or Rb did not result in additional information. After resection, the patient with SPC is free of disease for seven months. The IMT recurred three months after first surgery, but no relapses were found eight months after resurgery.ConclusionDifferential diagnosis can be difficult without immunohistochemistry. Therefore, a comprehensive morphological and immunohistochemical analysis is necessary, but markers of cell cycle (apart from the assessment of proliferation) do not help.


Head and Neck-journal for The Sciences and Specialties of The Head and Neck | 2010

LARYNGEAL INFLAMMATORY MYOFIBROBLASTIC TUMORS: DIFFERENT CLINICAL APPEARANCE AND HISTOMORPHOLOGIC PRESENTATION OF ONE ENTITY

Hans-Ullrich Völker; Matthias Scheich; Andreas Zettl; Rudolf Hagen; Hans Konrad Müller-Hermelink; Stefan Gattenlöhner

Inflammatory myofibroblastic tumors (IMFTs) of the larynx are rare. We report the clinical presentation, histomorphology, and new molecular findings of 2 cases.


Diagnostic Pathology | 2009

Expression of p-AKT characterizes adenoid cystic carcinomas of head and neck with a higher risk for tumor relapses

Hans-Ullrich Völker; Matthias Scheich; Annette Berndt; Imme Haubitz; Alexandra Metzger; Hans-Konrad Müller-Hermelink; Ulrike Kämmerer; Melanie Schmidt

BackgroundAdenoid cystic carcinomas are rare tumors with an indolent clinical course, but frequent local relapses. The identification of tumors with a higher relapse risk seems to be interesting. Hence we investigated parameters of glucose metabolism, which were found associated with poor prognosis in other malignancies.MethodsSpecimen of 29 patients were investigated immunohistochemically with antibodies against p-AKT, TKTL-1 (transketolase-like 1), M2PK (M2 pyruvate kinase), and GLUT-1. Proliferation was investigated by staining with Ki67. The tumors were located at the major or minor salivary glands. Only the typical cribriform subtype was investigated. The initial tumor stage was pT1 or pT2.ResultsExpression of p-AKT was significantly (P = 0.036) associated with a higher relapse risk in multivariate analysis. Low expression of M2PK was non-significantly (P = 0.065) predictive for a higher risk. TKTL-1 and GLUT-1 were expressed in the majority of cases, albeit not associated with relapse risk.ConclusionAdenoid cystic carcinomas positive for p-AKT show a higher relapse risk. However, other parameters of glucose metabolism investigated here or proliferation (Ki67) were not predictive in this entity. Our findings demonstrate a possible background for therapeutic approaches targeting the inhibition of PI3K/AKT pathway.


World Journal of Surgical Oncology | 2009

Lymphangiosis carcinomatosa in squamous cell carcinomas of larynx and hypopharynx--value of conventional evaluation and additional immunohistochemical staining of D2-40.

Hans-Ullrich Völker; Matthias Scheich; Isabell Nowack; Alexandra Metzger; Imme Haubitz; Bernhard Puppe; Rudolf Hagen; Hans-Konrad Müller-Hermelink; Christiane Völter

BackgroundRecent studies revealed a predictive value of lymphatic vessel invasion (L1) for the nodal metastasizing and poor prognosis in malignant tumors at different sites. The monoclonal antibody D2-40 (podoplanin) stains specifically endothelial cells of lymphatic vessels and improves the search for L1. However, the importance of this immunohistochemical staining was not investigated in squamous cell carcinomas (SCC) of larynx and hypopharynx.AimThis study was performed to compare the diagnostic potential of convential and immunohistochemical determination of L1 in SCC of larynx and hypopharynx with special respect to the predictive value for nodal metastasizing and prognosis.Methods119 SCCs of the larynx (n = 70) respectively hypopharynx (n = 49) were investigated. The lymphatic vessel invasion was assessed by conventional method (HE stain) and immunohistochemical staining with an antibody against D2-40 (DAKO, Germany). Immunohistochemistry was performed in accordance with manufacturers protocol. L1 was searched microscopically in a standardized magnification (×200) in serial sections of tumor samples (1 section per cm tumor diameter).ResultsThe immunohistochemical investigation did not show significant advantages for the prediction of regional nodal metastases. Despite a low sensitivity (< 50%) in both methods, the specifity can reach 80%. The negative predictive value in both methods seems acceptable (up to 80%), whereas the positive predictive value is not higher than 64%. Cases with L1 detected either conventionally or immunohistochemically did not show a significant shorter survival than cases with L0. However, a non-significant shorter survival was found. Only in SCC of hypopharynx, a combination of both methods revealed patients with a significant worse prognosis.ConclusionThe status of lymphatic vessel invasion should be documented in standardized tumor reports. A benefit of an additional immunohistochemical investigation was not found, for the daily routine HE-stain seems sufficient.


Head and Neck-journal for The Sciences and Specialties of The Head and Neck | 2009

Leiomyosarcoma of the larynx as a local relapse of squamous cell carcinoma—Report of an unusual case

Hans-Ullrich Völker; Andreas Zettl; Eugenia Haralambieva; Bernd Blume; Rudolf Hagen; Hans-Konrad Müller-Hermelink; Matthias Scheich

The authors report on leiomyosarcoma after previously treated squamous cell carcinoma (SCC) at the glottis.


Skull Base Surgery | 2017

Lesions Mimicking Small Vestibular Schwannomas

Matthias Scheich; Rudolf Hagen; Desiree Ehrmann-Müller; Brigitte Bison; Thomas Günthner-Lengsfeld; Camelia-Maria Monoranu; Hans-Ullrich Völker

Objective Most tumors of the internal auditory canal and cerebellopontine angle (CPA) are vestibular schwannomas (VSs). Preoperative diagnosis is based on typical clinical symptoms and radiological findings. In rare cases, histopathology can, however, show different results. Design This is a retrospective chart and database review. Setting The study was conducted at a tertiary skull base referral center at a university hospital. Participants A total of 207 consecutive cases of VS surgery via the middle cranial fossa approach performed between December 2005 and January 2015 were reviewed. Main Outcome Measures The main outcome measures were definitive histologic findings in 198 specimens, analysis of preoperative magnetic resonance imaging (MRI) and computed tomography. Results Histopathology revealed three meningiomas and two cases of lipochoristomas. Clinical presentation was typical for VS in all five cases. In preoperative MRI, all tumors were suspected to be VSs. Retrospective analysis of the preoperative imaging did not lead to a modification of the diagnosis. Intraoperative findings showed increased adherence of the tumor to the adjacent tissue in two of the five cases. Conclusion CPA lesions other than VSs are unusual but have to be taken into account. In very small tumors, imaging still remains difficult.


Journal of International Advanced Otology | 2017

Complications of the Middle Cranial Fossa Approach for Acoustic Neuroma Removal

Matthias Scheich; Christian Ginzkey; Desiree Ehrmann Muller; Wafaa Shehata Dieler; Rudolf Hagen

OBJECTIVE To analyze postoperative complications after microsurgery for acoustic neuroma (AN) via the middle fossa approach (MFA). MATERIALS AND METHODS In total, 203 consecutive patients of a tertiary skull base referral center at a university hospital were included in this retrospective chart and database analysis. All patients had undergone primary microsurgery at the Otorhinolaryngology department via MFA between December 2005 and October 2014. Postoperative complications were documented during the inpatient stay and outpatient follow-up. RESULTS Overall, 41 complications were registered in 35 patients. The most common was cerebrospinal fluid (CSF) leakage in 13% of the patients. Bleeding complications were documented in seven patients: two cerebellar bleedings, one subdural and one epidural hematoma, two hematomas of the skin, and one bleeding through the closed wound. Two patients experienced meningitis and one patient had a transient ischemic attack. Furthermore, three cases of deep vein thrombosis occurred, which led to a lethal pulmonary embolism in one case. One patient sustained temporary palsy of the vocal fold and another reported antibiotic-associated diarrhea. CONCLUSION Acoustic neuroma surgery via the MFA can be conducted with low morbidity and mortality. The most common complication is CSF leakage, which can be treated in most cases in a stepwise conservative manner. Severe adverse events that may require revision surgery are very scarce (1%).


European Archives of Oto-rhino-laryngology | 2007

Overexpression of transketolase TKTL1 is associated with shorter survival in laryngeal squamous cell carcinomas

Hans-Ullrich Völker; Matthias Scheich; Bernd Schmausser; Ulrike Kämmerer; Matthias Eck


European Archives of Oto-rhino-laryngology | 2013

Outcome on hearing and facial nerve function in microsurgical treatment of small vestibular schwannoma via the middle cranial fossa approach

Christian Ginzkey; Matthias Scheich; Wilma Harnisch; Verena Bonn; Desiree Ehrmann-Müller; Wafaa Shehata-Dieler; Robert Mlynski; Rudolf Hagen


European Archives of Oto-rhino-laryngology | 2014

Quality of life after microsurgery for vestibular schwannoma via the middle cranial fossa approach

Matthias Scheich; Christian Ginzkey; Edith Reuter; Wilma Harnisch; Desiree Ehrmann; Rudolf Hagen

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Rudolf Hagen

University of Würzburg

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