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Maurice M. Coombs

Lincoln's Inn

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Publication

Featured researches published by Maurice M. Coombs.

Archives of Biochemistry and Biophysics | 1976

Identification of Monohydroxy metabolites of 15,16-dihydrocyclopenta(a)phenanthren-17-one and its carcinogenic 11-methyl homolog produced by rat liver preparations in vitro.

Maurice M. Coombs; Maureen Hall; Colin W. Vose

Abstract Incubation of 15,16-dihydrocyclopenta[a]phenanthren-17-one and its carcinogenic 11-methyl homolog with rat liver microsomes led to similar patterns of metabolites. The carcinogen was the more slowly metabolized, but both ketones gave the corresponding 15-hydroxy derivatives, together with small quantities of the isomeric 16-ols. The 11-hydroxymethyl-17-ketone also occurred as a minor carcinogen metabolite. Incubation of the carcinogen with rat liver homogenates caused more extensive metabolism. The ratio of mono-ols to more polar metabolites was similar with homogenates from untreated and methylcholanthrene-induced rats, but increased metabolism to polar derivatives was observed after phenobarbitone induction.

Carcinogenesis | 1988

Structure–activity relationships for epidermal ornithine decarboxylase induction and skin tumor promotion by anthrones

John DiGiovanni; Francis H. Kruszewski; Maurice M. Coombs; Tarlochan S. Bhatt; Abbas Pezeshk

Cancer Research | 1983

Mutagenesis in Chinese Hamster Cells by Cyclopenta(a)phenanthrenes Activated by a Human Hepatoma Cell Line

Tarlochan S. Bhatt; Maurice M. Coombs; John DiGiovanni; Leila Diamond

Carcinogenesis | 1981

Microsomal metabolites of the aryl hydrocarbon hydroxylase and tumour inhibitor 7,8-benzoflavone

Maurice M. Coombs; Tarlochan S. Bhatt; C.W. Vose

Journal of Labelled Compounds and Radiopharmaceuticals | 1970

The synthesis and purification of 4-[14C]- and 7α[3H]-androsta-4,16-dien-3-one

M. Wilkinson; Maurice M. Coombs; D. B. Gower

Carcinogenesis | 1984

The effect of methyl substituents on the in vitro metabolism of cyclopenta[a]phenanthren-17-ones: implications for biological activity

Stephen T. Hadfield; Peter J. Abbott; Maurice M. Coombs; Alex F. Drake

Carcinogenesis | 1982

The influence of various enzyme inducers on the microsomal metabolism of 7,8-benzoflavone

Maurice M. Coombs

Carcinogenesis | 1982

Carcinogenicity and mutagenicity of some alkoxy cyclopenta[a]-phenanthren-17-ones: effect of obstructing the bay region

Tariochan S. Bhatt; Stephen T. Hadfield; Maurice M. Coombs

Carcinogenesis | 1981

DNA adducts of the carcinogen, 15, 16-dihydro-11-methylcyclo-penta(a)phenanthren-17-one, in vivo and in vitro : high pressure liquid chromatographic separation and partial characterization

Peter J. Abbott; Maurice M. Coombs

Journal of Mass Spectrometry | 1977

Mass spectrometry of cyclopenta[a]phenanthrenes. Metabolites formed in vitro and in vivo from the carcinogen 15,16‐dihydro‐11‐methylcyclopenta[a]phenanthren‐17‐one

C. W. Vose; Maurice M. Coombs

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John DiGiovanni

University of Texas System

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Francis H. Kruszewski

University of Texas System

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Leila Diamond

Wistar Institute

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Alex F. Drake

King's

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D. B. Gower

Guy's Hospital

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